The sensing response of bio-FETs relies on the selective binding of analytes (e.g., H + , metal ions, and biomolecules) onto the channel surface, which results in the alternations in channel conductance and electrical signals. [5][6][7] Therefore, semiconductor nanomaterials susceptive to surface potential changes are excellent channel materials for highly sensitive bio-FETs. [8][9][10][11] However, in contrary to conventional FETs, the nanoscale channels in bio-FETs are often exposed to the electrolytes, in which the interference of background ions in the electrolyte will disturb sensing signals, leading to high leakage current and eventually poor stability of the device over long-term measurements. [12,13] To date, this still represents one major challenge for bio-FETs to realize continuous biosensing with low-power dissipation and long-term stability. [14,15]