High mean platelet volume to platelet count ratio as a predictor on poor outcomes after CABG

Tüysüz, Mehmet Erin; Dedemoğlu, Mehmet

doi:10.1007/s11748-019-01202-7

Cited by 14 publications

(12 citation statements)

References 28 publications

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“…[ 16 ] Recent study showed that a high MPV/Plt ratio is associated with vein-graft occlusion and poor outcomes in the early period after CABG. [ 17 ] To our best knowledge, the correlations of MPV/Plt ratio with ischemic lesion volume in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke have not been well investigated. In our study we sought to determine whether MPV/Plt ratio on admission differs in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke.…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke

et al. 2020

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Ischemic stroke subtypes such as patients with large artery atherosclerosis, cardioembolism, and embolic stroke of undetermined source were investigated. This study was performed aimed to determine mean platelet volume (MPV) and mean platelet volume/platelet count (MPV/Plt) ratio in nonvalvular atrial fibrillation (AF) stroke and large artery atherosclerosis (LAA) stroke. We conducted a retrospective study of consecutive patients for treatment of acute ischemic stroke at Ruian People's Hospital from March 2017 to October 2018. The patients with ischemic stroke caused by AF and LAA were recruited to this study. Ischemic stroke was confirmed by magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA), ischemic lesions on diffusion-weighted imaging were measured in terms of size, composition, and pattern. MPV and platelet count were examined and (MPV/Plt) ratio was calculated. Three hundred seventy one patients were enrolled composing of 177 (47.7%) nonvalvular AF and 194 (52.2%) with LAA. The MPV (11.3 ± 1.3 vs 10.8 ± 1.0, P < .001) and MPV/Plt ratio (0.066 ± 0.025 vs 0.055 ± 0.20, P < .001) were much higher in AF group than LAA group. Receiver-operating characteristic (ROC) analysis showed MPV (AUC: 0.624, confidence interval: 0.567–0.68, P < .001) and MPV/Plt (AUC: 0.657, confidence interval: 0.601–0.713, P < .001) predicted AF between the 2 groups. MPV/Plt ratio was negatively associated with lesion volume ( r = –0.161, P = .033) in AF. The analyses of subtypes of composition of infarcts and infarct pattern showed that MPV/Plt ratio was almost higher in AF than LAA except for subcortical-only pattern. Multivariable regression analyses demonstrated National Institutes of Health Stroke Scale (NIHSS) score ( r = 2.74; P < .001), LAD ( r = –1.15; P = .025) and MPV/Plt ratio ( r = –180.64; P = .021) were correlated with lesion volume. Our results indicated elevated MPV and MPV/Plt ratio for the identification of difference between AF and LAA in patients with ischemic stroke.

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Section: Introductionmentioning

confidence: 99%

Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke

et al. 2020

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“…Research has found that RDW is superior to MPV in predicting postoperative results in cardiac surgery, and even three parameters consisting of NLR-MPV-RDW are higher than the two parameters (1) . Similarly, MPV is a prognostic factor in another study, and studies have demonstrated that the MPV/platelet count ratio is effective in determining poor postoperative outcomes (16) . Considering that higher RDW is the leading poor outcome predictor, MPV can be said to be a less valuable marker.…”

Section: Discussionmentioning

confidence: 86%

“…As RDW values, MPV levels increase with inflammation. Although the number of platelets decrease after CABG, the tendency to thrombosis increases due to large and reactive platelets (1,16) . In studies, high MPV levels were associated with negative results such as postoperative atrial fibrillation, early vein-graft occlusion, and increased mortality (1,17,18) .…”

Section: Discussionmentioning

confidence: 99%

Effects of Intravenous Versus Inhalational Anesthesia on Red Cell Distribution Width and Mean Platelet Volume in Patients Undergoing Coronary Artery Surgery

Özay¹,

Demir²,

Balcı³

et al. 2021

Jarss

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INTRODUCTION: The effects of midazolam-based intravenous anesthesia (TIVA) and sevoflurane-based inhalation anesthesia (SEVO) maintenance on postoperative hematological parameters were compared in patients undergoing coronary artery surgery. METHODS: The 100 patients included in the study were divided into two groups according to the anesthesia management: All patients' anesthesia inductions were performed with 10 μgkg-1 fentanyl, 0.15 mgkg-1 midazolam, and 0.8 mgkg-1 rocuronium. Anesthesia was maintained with total intravenous anesthesia in the TIVA group patients, while sevoflurane was used in the SEVO group patients. Demographic, clinical, operative data, red cell distribution width (RDW), and mean platelet volume (MPV) values were recorded. RESULTS: Except that the extubation time was shorter in the SEVO group, no difference was observed between the groups in terms of all these variables. There was a significant increase in postoperative RDW and MPV measurements in both groups. Postoperative RDW value was lower in the inhalation anesthesia group compared to the TIVA group (p=0.013). DISCUSSION AND CONCLUSION: In our study, RDW was found to be lower in the inhalation anesthesia group, indicating less inflammation. There was no difference in terms of postoperative complications and mortality.

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“…Mean Platelet Volume/Platelet count (MPV/Plt) ratio is a new marker and it has reported that predicted 90-day outcome in LAA stroke (16). Recent study showed that a high MPV/Plt ratio is associated with vein-graft occlusion and poor outcomes in the early period after CABG (17). To our best knowledge, the correlations of MPV/Plt ratio with ischemic lesion volume in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke have not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke

Zhu¹,

Shu

Jiang

et al. 2019

Preprint

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Objective Ischemic stroke subtypes such as patients with large artery atherosclerosis, cardioembolism and embolic stroke of undetermined source were investigated. This study was performed aimed to determine mean platelet volume (MPV) and mean platelet volume/platelet count (MPV/Plt) Ratio in nonvalvular atrial fibrillation (AF) stroke and large artery atherosclerosis (LAA) stroke.Methods We conducted a retrospective study of consecutive patients for treatment of acute ischemic stroke at Ruian People's Hospital from March 2017 to October 2018. The patients with ischemic stroke caused by AF and LAA were recruited to this study. Ischemic stroke was confirmed by MRI and MRA, ischemic lesions on diffusion-weighted imaging were measured in terms of size, composition, and pattern. MPV and platelet count were examined and (MPV/Plt) Ratio was calculated.Results 371 patients were enrolled composing of 177 (47.7%) nonvalvular AF and 194 (52.2%) with LAA. The MPV (11.3 ± 1.3 vs. 10.8 ±1.0, p﹤0.001) and MPV/Plt ratio (0.066±0.025 vs. 0.055±0.20, p﹤0.001) were much higher in AF group than LAA group. ROC analysis showed MPV (AUC: 0.624, confidence interval:0.567-0.68,p﹤0.001) and MPV/Plt (AUC: 0.657, confidence interval:0.601-0.713,p﹤0.001) predicted AF between the two groups. MPV/Plt ratio was negatively associated with lesion volume (r = -0.161, p = 0.033) in AF. The analyses of subtypes of composition of infarcts and infarct pattern showed that MPV/Plt ratio was almost higher in AF than LAA except for subcortical-only pattern. Multivariable regression analyses demonstrated NIHSS score (r = 2.74; p﹤0.001), LAD (r = -1.15; P = 0.025) and MPV/Plt ratio (r = -180.64; P = 0.021) were correlated with lesion volume.Conclusion Our results indicated elevated MPV and MPV/Plt ratio for the identification of difference between AF and LAA in patients with ischemic stroke.

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High mean platelet volume to platelet count ratio as a predictor on poor outcomes after CABG

Cited by 14 publications

References 28 publications

Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke

Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke

Effects of Intravenous Versus Inhalational Anesthesia on Red Cell Distribution Width and Mean Platelet Volume in Patients Undergoing Coronary Artery Surgery

Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke

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