High Fatty Diet Effects on Rat Liver

Karacor, Kayihan; Cam, Meryem; Orhan, Nuri; Coşgun, Erdal; Demırın, Hilmi

doi:10.15197/sabad.1.11.47

Cited by 11 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was also a noticeable sinusoidal dilatation (Figure e). In this group, portal area revealed moderate fibrosis with little mononuclear inflammatory cells infiltration (Figures f and b) as mentioned by Karaçor et al (). Mitochondrial dysfunction is thought to play a central role in nonalcoholic fatty liver disease as a production of reactive oxygen species, inflammation, hepatocellular apoptosis, and oxidative stress.…”

Section: Resultssupporting

confidence: 82%

“…MDA is a metabolic product of lipid peroxidation and is used as a marker for oxidative damage on liver tissue (Karaçor et al, ). MDA was illustrated in Table and its high degree on positive control group was clear.…”

Section: Resultsmentioning

confidence: 99%

“…The MP-NabM may interfere with liver enzymes due to polyphenol-rich material. Bioactive peptides and their antioxidant activity also have an impact (Karaçor, Çam, Orhan, Coşgun, & Demirin, 2014). On the other hand, phenolic, flavonoid, and mineral elements (Tables 1 and 2) combining to MPs and PHM or NabM may also contribute to the liver protection.…”

Section: Effect Of Feeding Total Milk Proteins and Wph With Psylliumentioning

confidence: 99%

“…MDA is a metabolic product of lipid peroxidation and is used as a marker for oxidative damage on liver tissue (Karaçor et al, 2014).…”

Section: Effect Of Feeding Total Milk Proteins and Wph With Phm Andmentioning

confidence: 99%

See 3 more Smart Citations

Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers

et al. 2020

View full text Add to dashboard Cite

Protein–polysaccharide interactions have been a focus of scientific attention. This study aimed to improve the antioxidant and hepatoprotective effects of buffalo total milk proteins and whey protein hydrolysate (WPH) through noncovalent interactions with Psyllium husk (ispaghula) mucilage (PHM) and Nabq mucilage (NabM). Chemical composition, phenolic content, and antioxidant activities of milk protein–mucilage complexes were explored. The effects of resulting complexes on liver function, hyperlipidemia, and histopathology of the liver in rats fed high‐fat diet (HFD) were investigated. The results showed that the complexes exerted significant effect on normalizing tested parameters; WPH–NabM had the most significantly decreased level of malondialdehyde content and the liver histopathological examination proved an improvement in all groups fed with these complexes. These complexes can be used as functional protection elements against the nonalcoholic fatty liver disease. Practical applications PHM, NabM, and their complexes with milk proteins were proved to improve liver function, enhancing most of its measurable parameters and also diminishing the risk of cardiovascular disease. Mice with HFD achieved better health circumstances by combining these ingredients in their diet. Knowing how much these diseases proliferate in the western world and its correlation with high‐fat consumption and modern lifestyle, its conjugation with PHM/NabM–MP complexes may reduce the negative impact of unhealthy food intake and, on some parameters, even improving the whole liver function. For that reason, the present study supports and pushes forward the dissemination and consumption of ispaghula or Nabq (the polysaccharides sources) or supplements originating from them. Although many interactions concerning milk proteins have already been analyzed, our study also proposes the interaction with bioactive polysaccharides as useful, opening a field of research aimed at the better application of milk proteins.

show abstract

Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Effect Of Feeding Total Milk Proteins and Wph With Psylliumentioning

confidence: 99%

“…MDA is a metabolic product of lipid peroxidation and is used as a marker for oxidative damage on liver tissue (Karaçor et al, 2014).…”

Section: Effect Of Feeding Total Milk Proteins and Wph With Phm Andmentioning

confidence: 99%

See 2 more Smart Citations

Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Moreover, BNL-CL2 cells exposed to OA became significantly more colonized in soft agar. These findings have revealed the fact that OA increases the in vivo tumorigenesis potentially (21).…”

Section: The Effect Of Oleic Acid On Tumor Tissuementioning

confidence: 89%

Effects of oleic acid

Karacor

Cam

2015

Med Sci and Discov

View full text Add to dashboard Cite

Content of fatty diet plays a significant role in the development and progression of chronic diseases. Generally, it is accepted that unsaturated fatty acids are beneficial. According to literature review, oleic acid (C18:1n-9) has positive impacts on various tissues in general and has negative impacts rarely. Olive oil composition includes high amount oleic acid. Considering of the effects of oleic acid on the cardiovascular system, it was determined that decreasing of the myocardial infarction rate, platelet aggregation and secretion of TXA2, plus reduce of the systolic blood pressure. LDL cholesterol was decreased. In terms of effects on the liver, while some studies suggest that oleic acid has beneficial effects, unlike other studies proved that exposed to oleic acid of hepatocytes induce ER (endoplasmic reticulum) stress in long-term period. The several studies which were investigating the efficacy of the oleic acid on the tumor tissue proved that OA increased to hepato-tumorigenesis in vivo as a potential. On te other hand, another research showed that oleic acid blocked the action of HER-2 / neu oncogene that led to breast cancer. Although some researchers reported that OA develop neutrophil phagocytic capacity and candidacidal activity, other researchers point out that these fatty acids didn't cause any changes on bactericidal activity and fatty acids caused moderate decreases on phagocytosis and chemotaxis only in extremely high concentrations, and they suppressed to T lymphocytes. Although, most of studies have indicated to beneficial effects of oleic acids, also the adverse effects of oleic acid have been reported in a few studies. This situation requires further researches for detail information about oleic acid

show abstract

(‐)‐Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high‐fat diet

Cheng

Zhao

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

High Fatty Diet Effects on Rat Liver

Abstract: Aim of this study was to investigate effects of high fat diet on rat liver and weight gain. By this purpose 30

Cited by 11 publications

References 35 publications

Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers

Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers

Effects of oleic acid

(‐)‐Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high‐fat diet

Contact Info

Product

Resources

About