Effects of oleic acid

Abstract

Content of fatty diet plays a significant role in the development and progression of chronic diseases. Generally, it is accepted that unsaturated fatty acids are beneficial. According to literature review, oleic acid (C18:1n-9) has positive impacts on various tissues in general and has negative impacts rarely. Olive oil composition includes high amount oleic acid. Considering of the effects of oleic acid on the cardiovascular system, it was determined that decreasing of the myocardial infarction rate, platelet aggregation and secretion of TXA2, plus reduce of the systolic blood pressure. LDL cholesterol was decreased. In terms of effects on the liver, while some studies suggest that oleic acid has beneficial effects, unlike other studies proved that exposed to oleic acid of hepatocytes induce ER (endoplasmic reticulum) stress in long-term period. The several studies which were investigating the efficacy of the oleic acid on the tumor tissue proved that OA increased to hepato-tumorigenesis in vivo as a potential. On te other hand, another research showed that oleic acid blocked the action of HER-2 / neu oncogene that led to breast cancer. Although some researchers reported that OA develop neutrophil phagocytic capacity and candidacidal activity, other researchers point out that these fatty acids didn't cause any changes on bactericidal activity and fatty acids caused moderate decreases on phagocytosis and chemotaxis only in extremely high concentrations, and they suppressed to T lymphocytes. Although, most of studies have indicated to beneficial effects of oleic acids, also the adverse effects of oleic acid have been reported in a few studies. This situation requires further researches for detail information about oleic acid

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“…A rapidly growing literature illustrates the benefits of PUFA, in relieving cardiovascular, inflammatory conditions, heart disease, atherosclerosis, autoimmune disorders, diabetes and other diseases 29 . According to the study of K. Karacor and M. Cam 30 , the high level of oleic acid in oil compositions, has positive effects on human health especially by In view of the slight difference in the lipid composition of the two oils, ultrasonic assisted extraction which is easy, fast, more economical and leads to sterile oils proved to be the most adequate.…”

Rutin bioconjugates as potential nutraceutical prodrugs: An in vitro and in ovo toxicological screening

“…Oleic acid (OA) is the most abundant MUFA in human nutrition, while linoleic acid (LA) is the major dietary PUFA (Baum et al, 2012;Choque et al, 2014). OA exerts a cardioprotective function, its supplementation being correlated with a lower risk of heart diseases (Karacor, 2015). LA was described as an essential fatty acid (Choque et al, 2014;Serini et al, 2011), being associated with a beneficial effect on the cardiac function, as well as reduced levels of plasma low-density lipoprotein cholesterol and liver fat, and improved hepatic metabolic status (Marangoni et al, 2020).…”

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

“…Oleic acid (OA) and linoleic acid (LNA) are mono-unsaturated omega-9 FA and poly-unsaturated omega-6 FA, respectively. Toxicity profiles of FA demonstrate positive impacts on various tissues as they generally pose no significant safety concern but have only low systemic toxicity potential ( Burnett et al , 2017 ; Karacor & Cam, 2015 ).…”