High-fat emulsion-induced rat model of nonalcoholic steatohepatitis

High Fatty Diet Effects on Rat Liver

“…Corn oil includes 24.1% oleic acid, 61.9% linoleic acid, 11% palmitic acid, 2% stearic acid and linolenic acid 0.07% (19) and linoleic acid (omega-6) has inflammatory, thrombotic, mitogenic and hyperalgesic effects (20). These negative effects may depend on amount of omega -6 fatty acids.…”

Blood F2-isoprostanes are significantly associated with abnormalities of lipid status in rats with steatosis

“…The purpose of using such dietary regimen in the normal rats was, by resembling a common fat-rich diet in humans (60% kcal of fat) without toxin ingestion and alimentary deficiency, to naturally reproduce typical features of metabolic abnormalities at the simple steatotic stage of NAFLD seen in humans [20,21] . As shown in Table 1, hepatic TG in the HF rats were elevated significantly, indicating an occurrence of lipotoxicity due to the imbalance between TG synthesis and degradation in the liver.…”

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease

“…The mechanisms by which they elicit these protective effects are unclear, although reductions in the magnitude of steatosis, oxidative stress and inflammatory pathway activation appear to be involved. Since long chain saturated fatty acids promote oxidative stress and activate inflammatory pathways in cells and tissues not exposed to alcohol [29,37,46,[98][99][100], it seems likely that the presence of alcohol alters metabolism of specific fatty acids within tissues. Subsequent studies that directly compare the effect of saturated fatty acids in models of alcoholic-and nonalcoholic fatty liver disease are needed to address these discrepancies.…”