High fat diet, gut microbiome and gastrointestinal cancer

Tong, Yao; Gao, Hongtao; Qi, Qiuchen; Liu, Xiaoyan; Li, Juan; Gao, Jie; Li, Peilong; Wang, Yunshan; Li, Du; Wang, Chuanxin

doi:10.7150/thno.56157

Cited by 72 publications

(56 citation statements)

References 255 publications

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“…Compared with the microbial prediction model, the metabolism model demonstrated higher test efficiency, which was consistent with the fact that the intestinal metabolites were more closely related to thyroid cancer in this microenvironment (32). However, since research on the influence of gut microbiota and metabolism in thyroid cancer is rare, further studies are required to establish a complete microenvironment diagnosis model (11).…”

Section: Discussionsupporting

confidence: 61%

Alterations of Gut Microbiome and Metabolite Profiles Associated With Anabatic Lipid Dysmetabolism in Thyroid Cancer

Gui

Jiang

et al. 2022

Front. Endocrinol.

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BackgroundCurrently, the high morbidity of individuals with thyroid cancer (TC) is an increasing health care burden worldwide. The aim of our study was to investigate the relationship among the gut microbiota community, metabolites, and the development of differentiated thyroid cancer.Methods16S rRNA gene sequencing and an integrated LC–MS-based metabolomics approach were performed to obtain the components and characteristics of fecal microbiota and metabolites from 50 patients with TC and 58 healthy controls (HCs).ResultsThe diversity and richness of the gut microbiota in the TC patients were markedly decreased. The composition of the gut microbiota was significantly altered, and the Bacteroides enterotype was the dominant enterotype in TC patients. Additionally, the diagnostic validity of the combined model (three genera and eight metabolites) and the metabolite model (six metabolites) were markedly higher than that of the microbial model (seven genera) for distinguishing TC patients from HCs. LEfSe analysis demonstrated that genera (g_Christensenellaceae_R-7_group, g_Eubacterium_coprostanoligenes_group) and metabolites [27-hydroxycholesterol (27HC), cholesterol] closely related to lipid metabolism were greatly reduced in the TC group. In addition, a clinical serum indicator (total cholesterol) and metabolites (27HC and cholesterol) had the strongest influence on the sample distribution. Furthermore, functional pathways related to steroid biosynthesis and lipid digestion were inhibited in the TC group. In the microbiota-metabolite network, 27HC was significantly related to metabolism-related microorganisms (g_Christensenellaceae_R-7_group).ConclusionsOur research explored the characteristics of the gut microecology of patients with TC. The findings of this study will help to discover risk factors that affect the occurrence and development of TC in the intestinal microecology.

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Section: Discussionsupporting

confidence: 61%

Alterations of Gut Microbiome and Metabolite Profiles Associated With Anabatic Lipid Dysmetabolism in Thyroid Cancer

Gui

Jiang

et al. 2022

Front. Endocrinol.

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“…This result suggests the negative relationship between Lachnospiraceae and inflammation, which is in line with previous study in mice [ 32 ]. Previous studies have shown that HFD can significantly alter the composition of gut microbes [ 36 ]. HFD might lead to increased hepatic retention of hydrophobic bile acids, which are significantly associated with changes in intestinal microorganisms [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Tea Treatments against High-Fat Diet-Induced Disorder by Regulating Lipid Metabolism and the Gut Microbiota

Wang

Liu

Sang

et al. 2022

Computational and Mathematical Methods in Medicine

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High-fat diet (HFD) may induce changes of metabolism and gut microbiota changes, and these changes are susceptible to diet adjustments such as tea treatment. However, the treatment effects may vary among different types of tea. In this study, we evaluated the effects of six types of tea on glucose and lipid metabolism and gut microbiota in HFD mice. We established HFD mouse model by 12 weeks feed with 60% fat diet, then treated with teas for six weeks. Here, we showed that treatment with different types of tea can inhibit weight gain and insulin resistance though different ways. Green tea regulated lipid metabolism by regulating the expression of adenosine 5 ′ -monophosphate-activated protein kinase (AMPK) and carnitine palmitoyltransferase-I (CPT-1). The effect of dark tea and white tea in reducing liver weight seemed to be related to activities of acetyl-CoA carboxylase (ACC). Yellow tea exhibited the best anti-inflammatory and antioxidant effects and effects of recovering the disorder of model mouse microbiota. The decrease in blood sugar and the upregulation of gluconeogenesis-related enzymes seemed to be related to the decrement of unclassified Lachnospiraceae. These different effects may result from the unique chemical compositions contained by different types of tea, which can regulate different lipid and glucose metabolism-related proteins. Despite variations in its compositions and metabolic reactions, tea is a potent antiobesity and hypoglycemic agent.

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“…As a public health problem, a high-fat diet has been shown to be associated with various digestive system diseases, cardiovascular diseases, urinary system diseases, tumors, etc. and can accelerate the occurrence of diseases due to inflammation and metabolic changes ( Yin et al., 2018 ; Tong et al., 2021 ). A high-fat diet is closely associated with changes in the gut microbiota.…”

Section: The Gut Microbiota In the Pathogenesis Of Hua And Goutmentioning

confidence: 99%

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Wang

Liao

et al. 2022

Front. Cell. Infect. Microbiol.

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The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. The gut microbiota, which colonizes the human intestine, has a mutually beneficial and symbiotic relationship with the host and plays a vital role in the host’s metabolism and immune regulation. Structural changes or imbalance in the gut microbiota could cause metabolic disorders and participate in the synthesis of purine-metabolizing enzymes and the release of inflammatory cytokines, which is closely related to the occurrence and development of the metabolic immune disease HUA and gout. The gut microbiota as an entry point to explore the pathogenesis of HUA and gout has become a new research hotspot. This review summarizes the characteristics of the gut microbiota in patients with HUA and gout. Meanwhile, the influence of different dietary structures on the gut microbiota, the effect of the gut microbiota on purine and uric acid metabolism, and the internal relationship between the gut microbiota and metabolic endotoxemia/inflammatory factors are explored. Moreover, the intervention effects of probiotics, prebiotics, and fecal microbial transplantation on HUA and gout are also systematically reviewed to provide a gut flora solution for the prevention and treatment of related diseases.

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High fat diet, gut microbiome and gastrointestinal cancer

Cited by 72 publications

References 255 publications

Alterations of Gut Microbiome and Metabolite Profiles Associated With Anabatic Lipid Dysmetabolism in Thyroid Cancer

Alterations of Gut Microbiome and Metabolite Profiles Associated With Anabatic Lipid Dysmetabolism in Thyroid Cancer

Effects of Tea Treatments against High-Fat Diet-Induced Disorder by Regulating Lipid Metabolism and the Gut Microbiota

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

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