Effects of Tea Treatments against High-Fat Diet-Induced Disorder by Regulating Lipid Metabolism and the Gut Microbiota

Abstract

High-fat diet (HFD) may induce changes of metabolism and gut microbiota changes, and these changes are susceptible to diet adjustments such as tea treatment. However, the treatment effects may vary among different types of tea. In this study, we evaluated the effects of six types of tea on glucose and lipid metabolism and gut microbiota in HFD mice. We established HFD mouse model by 12 weeks feed with 60% fat diet, then treated with teas for six weeks. Here, we showed that treatment with different types of tea can inhibit weight gain and insulin resistance though different ways. Green tea regulated lipid metabolism by regulating the expression of adenosine 5 ′ -monophosphate-activated protein kinase (AMPK) and carnitine palmitoyltransferase-I (CPT-1). The effect of dark tea and white tea in reducing liver weight seemed to be related to activities of acetyl-CoA carboxylase (ACC). Yellow tea exhibited the best anti-inflammatory and antioxidant effects and effects of recovering the disorder of model mouse microbiota. The decrease in blood sugar and the upregulation of gluconeogenesis-related enzymes seemed to be related to the decrement of unclassified Lachnospiraceae. These different effects may result from the unique chemical compositions contained by different types of tea, which can regulate different lipid and glucose metabolism-related proteins. Despite variations in its compositions and metabolic reactions, tea is a potent antiobesity and hypoglycemic agent.

Preventive Effects of Different Black and Dark Teas on Obesity and Non-Alcoholic Fatty Liver Disease and Modulate Gut Microbiota in High-Fat Diet Fed Mice

“…However, the administration of all six teas substantially inhibited the elevated liver weight and hepatic TG level induced by the HFD-feeding. The results indicated that these black and dark teas could attenuate the abnormal lipid accumulation in liver caused by the prolonged HFD exposure, which agreed with the effects of other tea type (such as green tea) reported by the previous study [ 37 ]. In recent years, a growing number of studies have identified tea supplementation as a potentially implementable nutritional strategy to protect against the hepatic impairment and abnormal lipid metabolism in the liver [ 24 , 38 ].…”

An Ilex latifolia‐containing compound tea regulates glucose–lipid metabolism and modulates gut microbiota in high‐fat diet‐fed mice

“…Many studies have shown that tea polyphenols can regulate intestinal function and reduce high blood glucose and lipids caused by glucose and lipid metabolism disorders (Lim et al., 2022; Wu et al., 2022). Our results are consistent with those of previous research, confirming that CKT plays an important role in regulating glucose and lipid metabolism (Wang, Liu, et al., 2022). In addition, there are many studies showing that Kuding Tea, GT, and Luohan fruit have no ill effects under the normal diet.…”

Folic acid ameliorates alcohol-induced liver injury via gut–liver axis homeostasis

“…Lachnospiraceae members are short-chain fatty acid propionate producers and microbiota composition modulators in the gut ( 56 ). And the increase of unclassified_Lachnospiraceae could be a signature of positive effects ( 57 ). To identify the specific bacterial taxa after folic acid supplementation, LEfSe analysis was conducted, with a threshold of 4.0 as the log LDA fraction of the distinguishing feature.…”