Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Wang, Zhilei; Li, Yuchen; Liao, Wenhao; Huang, Ju; Liu, Yanping; Li, Zhiyong; Tang, Jianguo

doi:10.3389/fcimb.2022.935723

Cited by 42 publications

(31 citation statements)

References 132 publications

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“…In the hindgut of pregnant goats, we detected a high abundance of adenine and purine metabolites, mainly deoxyadenosine, 2′-deoxyinosine, and 5′-deoxyadenosine, which were negatively correlated with the abundance of the genus Family_XIII_AD3011_group . Previous studies have shown that intestinal microbiota can be involved in purine metabolism in the body, and in patients with high uric acidity, the abundance of Bacteroides caccae and Bacteroides xylanisolvens was significantly increased, and the levels of Prevotella spp, Ruminococcus spp, and Lactobacillus spp were decreased ( 33 ). Escherichia coli , Lactobacillus , and Pseudomonas can secrete xanthine dehydrogenase, an enzyme in the oxidative metabolism of purines, responsible for the conversion of xanthine into uric acid ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model

Zhang

Liu

et al. 2023

Microbiol Spectr

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Our findings revealed that the activity of Family_XIII_AD3011_group and Corynebacterium is strongly correlated with the beneficial regulation of physiological hormones and metabolic changes during pregnancy and lactation. These findings are key for guiding targeted microbial therapeutic approaches to modulate microbiomes in gestating and lactating mammals.

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Section: Discussionmentioning

confidence: 99%

Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model

Zhang

Liu

et al. 2023

Microbiol Spectr

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“…Recent researches have found a close association between intestinal flora and hyperuricemia. It was found that HUA mice and normal mice have significantly different intestinal flora composition and structure [ 59 ]. This situation was also observed during our study.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Mannuronate Oligosaccharides on Hyperuricemic Mice via Promoting Uric Acid Excretion and Modulating Gut Microbiota

et al. 2023

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Mannuronate oligosaccharide (MOS) is α-D-mannuronic acid polymer with 1,4-glycosidic linkages that possesses beneficial biological properties. The aim of this study was to investigate the hypouricemic effect of MOS in hyperuricemic mice and demonstrate the possible protective mechanisms involved. In this research, 200 mg/kg/day of MOS was orally administered to hyperuricemic mice for four weeks. The results showed that the MOS treatment significantly reduced the serum uric acid (SUA) level from 176.4 ± 7.9 μmol/L to 135.7 ± 10.9 μmol/L (p < 0.05). MOS alleviated the inflammatory response in the kidney. Moreover, MOS promoted uric acid excretion by regulating the protein levels of renal GLUT9, URAT1 and intestinal GLUT9, ABCG2. MOS modulated the gut microbiota in hyperuricemic mice and decreased the levels of Tyzzerella. In addition, research using antibiotic-induced pseudo-sterile mice demonstrated that the gut microbiota played a crucial role in reducing elevated serum uric acid of MOS in mice. In conclusion, MOS may be a potential candidate for alleviating HUA symptoms and regulating gut microbiota.

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“…Furthermore, the changed gut microbes in patients with PDC were mainly associated with carbohydrate and amino acid metabolism, mineral absorption, lipopolysaccharide biosynthesis, primary bile acid biosynthesis, and so on. The altered gut microbial composition and function correspond to the clinical findings of HUA [ 57 ]. Therefore, the metabolic characteristics of people with PDC or DHC may be the reasons underlying the pathology of HUA.…”

Section: Discussionmentioning

confidence: 99%

The Correlation between Traditional Chinese Medicine Constitution and Hyperuricemia and Gout: A Systematic Review and Meta‐Analysis

Jiang

Chen

You

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the correlation between the constitution of traditional Chinese medicine (TCM) and hyperuricemia (HUA) and gout. Method. Databases including China National Knowledge Infrastructure (CNKI), WanFang Data, China Science and Technology Journal Database (VIP), China Biology Medicine Disc (CBMdisc), PubMed, The Cochrane Library, Web of Science, and Excerpta Medical Database (Embase) were searched to collect observational studies about TCM constitution in HUA and gout from inception to November 21, 2021. The distribution of TCM constitution types in HUA and gout patients was presented by proportion, while the correlation was presented by odds ratio (OR) and 95% CI. Meta-analysis was performed using StataCorp Stata (STATA) version 16.0 software. Results. Twenty-one cross-sectional studies and 10 case-control studies involving 38028 samples were included, among which 27526 patients were diagnosed with HUA and 2048 patients with gout. Phlegm-dampness constitution (PDC), damp-heat constitution (DHC), and qi-deficiency constitution (QDC) are the most common types, accounting for 24% (20%–27%), 22% (16%–27%), and 15% (12%–18%), respectively, in HUA patients, while DHC, PDC, and blood stasis constitution (BSC) accounted for 28% (18%–39%), 23% (17%–29%), and 11% (8%–15%), respectively, in gout patients. PDC and DHC were the main constitution types in patients with HUA or gout in south China, east China, north China, southwest China, northwest China, and northeast China. There was no difference in the distribution of PDC and QDC in male or female patients with HUA, while males with DHC in HUA were more common than females. The proportion of PDC or DHC among HUA patients was 1.93 times and 2.14 times higher than that in the general population (OR and 95% CI: 1.93 (1.27, 2.93), 2.14 (1.47, 3.13)), while the proportions of PDC, DHC, and BSC were 3.59 times, 4.85 times, and 4.35 times higher than that of the general groups (OR and 95% CI: 3.59 (1.65, 7.80), 4.85 (1.62, 14.57), and 4.35(2.33, 8.11)). Conclusion. PDC, DHC, and QDC are the main constitution types of patients with HUA, while PDC and QDC may be the risk factors for HUA. DHC, PDC, and BSC are the main constitution types of patients with gout, and they may be the risk factors for gout. In clinical and scientific research, more attention should be paid to the relationship between the above-mentioned TCM constitution in HUA or gout. Nevertheless, because the quality of the included observational studies is low, more prospective cohort studies related to TCM constitution and HUA or gout can be carried out to verify the causality between TCM constitution and HUA or gout.

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Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Cited by 42 publications

References 132 publications

Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model

Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model

Ameliorative Effect of Mannuronate Oligosaccharides on Hyperuricemic Mice via Promoting Uric Acid Excretion and Modulating Gut Microbiota

The Correlation between Traditional Chinese Medicine Constitution and Hyperuricemia and Gout: A Systematic Review and Meta‐Analysis

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