High dietary intake of branched‐chain amino acids is associated with an increased risk of insulin resistance in adults

Asghari, Golaleh; Farhadnejad, Hossein; Teymoori, Farshad; Mirmiran, Parvin; Tohidi, Maryam; Azizi, Fereidoun

doi:10.1111/1753-0407.12639

Cited by 76 publications

(60 citation statements)

References 36 publications

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“…Ethnic differences, reflecting underlying differences in genetic variants, may be responsible for such differences. In the study of Asghari et al in the current issue of the Journal of Diabetes , BCAA intake was associated with the development of subsequent IR. Studies of bariatric surgery suggest lower basal and post‐insulin infusion BCAA levels are associated with greater insulin sensitivity, with reductions in BCAA not seen with weight loss per se with gastric band procedures, but occurring after Roux‐en‐Y gastric bypass, an intervention that may have metabolic benefits over and above those from reduction in body weight.…”

mentioning

confidence: 86%

Diabetes and branched‐chain amino acids: What is the link?

Bloomgarden

2018

Journal of Diabetes

180

119

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Diabetes and branched-chain amino acids: What is the link?Branched-chain amino acids (BCAA) have increasingly been studied as playing a role in diabetes, with the PubMed search string "diabetes" AND "branched chain amino acids" showing particular growth in studies of the topic over the past decade (Fig. 1). In the Young Finn's Study, BCAA and, to a lesser extent, the aromatic amino acids phenylalanine and tyrosine were associated with insulin resistance (IR) in men but not in women, whereas the gluconeogenic amino acids alanine, glutamine, or glycine, and several other amino acids (i.e. histidine, arginine, and tryptophan) did not show an association with IR.

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mentioning

confidence: 86%

Diabetes and branched‐chain amino acids: What is the link?

Bloomgarden

2018

Journal of Diabetes

180

119

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“…In collaboration with the Bioinformatics Department of the University of Montpellier, preliminary work was initiated for constraint programming. Such an algorithm will not solve the difficult problem of menu planning but can be useful in determine BCAA content in food repertoires in rare cases of inborn errors of metabolism due to genetic defects in BCAA catabolism specific for each of the three BCAA [ 24 ]. Other features to be considered in the near future include the possibility of the administrator calculating recipes similar to the former SIDI program, use of more languages such as Arabic, which would be useful in North Africa, and adaptation of the program for smartphones.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, plasma BCAA levels are now considered as metabolic signatures of “diabesity” or MetS and are used as potential biomarkers for the development of diabetes [ 16 , 19 , 20 , 21 , 22 , 23 ]. In humans, high BCAA intake has been associated with an increased risk of T2D and insulin resistance incidences [ 15 , 24 ]. However, both long- and short-term interventional studies involving lean or obese populations showed rather contradictory results [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations

Haydar

Paillot²,

Fagot³

et al. 2018

Nutrients

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Branched-chained amino acids (BCAA) are essential dietary components for humans and can act as potential biomarkers for diabetes development. To efficiently estimate dietary intake, we developed a BCAA database for 1331 food items found in the French Centre d’Information sur la Qualité des Aliments (CIQUAL) food table by compiling BCAA content from international tables, published measurements, or by food similarity as well as by calculating 267 items from Greek, Turkish, Romanian, and Moroccan mixed dishes. The database embedded in MEDIPAD software capable of registering 24 h of dietary recalls (24HDR) with clinical and genetic data was evaluated based on archived 24HDR of the Saint Pierre Institute (France) from 2957 subjects, which indicated a BCAA content up to 4.2 g/100 g of food and differences among normal weight and obese subjects across BCAA quartiles. We also evaluated the database of 119 interviews of Romanians, Turkish and Albanians in Greece (27–65 years) during the MEDIGENE program, which indicated mean BCAA intake of 13.84 and 12.91 g/day in males and females, respectively, comparable to other studies. The MEDIPAD is user-friendly, multilingual, and secure software and with the BCAA database is suitable for conducting nutritional assessment in the Mediterranean area with particular facilities for food administration.

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“…24 Some of them indicate detrimental effects, such as the promotion of IR, metabolic dysfunctions and DM2. 56,57 Others suggest beneficial outcomes, including a decreased risk of DM2, 7,58 which, in the light of the above considerations, may seem paradoxical. However, it should be mentioned that both Leu and Ile have the capacity to increase glucose clearance by different modes of action: by the promotion of insulin secretion (Leu) as well as in insulin-and mTOR-independent mechanisms: by increasing cellular uptake (Leu and Ile), by promoting glycogenogenesis (Leu) and by downregulating gluconeogenesis (Ile).…”

Section: Does Dietary Bcaa Matter?mentioning

confidence: 99%

Branched chain amino acids: Passive biomarkers or the key to the pathogenesis of cardiometabolic diseases?

Siomkajło¹,

Daroszewski²

2019

Adv Clin Exp Med

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The metabolomic approach to research on lifestyle diseases has led to the discovery of new potential biomarkers of pathological conditions as well as key metabolic pathways that may become targets of therapeutic intervention. Current evidence supports plasma branched chain amino acids (BCAAs) as potential diagnostic and prognostic biomarkers of cardiometabolic diseases. However, the biological mechanisms of the associations that have been identified are still not completely understood and should be clarified before implementing BCAA-based biomarkers in the clinical setting. The most crucial issue that needs to be solved first is determining whether BCAA plasma profile disturbances are only passive biomarkers or whether they facilitate dysmetabolic processes. In this context, further research is also warranted to investigate the role of dietary BCAAs. Gaining this knowledge would be significant progress in molecular nutrition research, providing perspective for target therapeutic and prophylactic interventions. This paper provides a comprehensive review of the main hypotheses and mechanistic models that consider circulating BCAAs both as passive biomarkers and as contributors to cardiometabolic diseases.

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High dietary intake of branched‐chain amino acids is associated with an increased risk of insulin resistance in adults

Abstract: The findings of this study support the hypothesis that higher intakes of BCAAs may have adverse effects on the development of IR.

Cited by 76 publications

References 36 publications

Diabetes and branched‐chain amino acids: What is the link?

Diabetes and branched‐chain amino acids: What is the link?

Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations

Branched chain amino acids: Passive biomarkers or the key to the pathogenesis of cardiometabolic diseases?

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