Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations

Haydar, Sara; Paillot, T.; Fagot, C.; Cogne, Yannick; Fountas, Athanasios; Tütüncü, Yıldız; Vintila, Madalina; Tsatsoulis, Agathocles; Thanh, Pham Thi Hong; Garandeau, Patrick; Chetea, Dan; Badiu, Corin; Gheorghiu, Monica Livia; Ylli, Dorina; Lautier, Corinne; Jarec, Morana; Monnier, L.; Normand, Christophe; Šarac, Jelena; Barakat, Abdelhamid; Missoni, Saša; Pugeat, Michel; Poucheret, Patrick; Hanzu, Felicia A.; Gomis, Ramón; Macías, Josep Maria; Litvinov, Serghey; Khusnutdinova, Elza; Poiană, Cătălina; Pasquali, Renato; Lauro, Davide; Sesti, Giorgio; Trischitta, Vincenzo; Abdelhak, Sonia; Zenati, Akila; Ylli, Agron; Satman, İlhan; Kanninen, Timo; Rinato, Yves; Grigorescu, Florin

doi:10.3390/nu10101392

Cited by 5 publications

(4 citation statements)

References 61 publications

(72 reference statements)

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“…Branched-chain amino acids (BCAAs) are leucine, isoleucine, and valine amino acids metabolized primarily within the skeletal muscle [ 1 ]. BCAAs are found in different amounts in red meat and poultry (36.3%), milk and dairy products (16.7%), cheese (9.8%), bread, pasta, and cereals (17.3%), and legumes (4.8%) [ 2 ]. In addition, BCAA supplements are commercially available in different dosages (from 600 mg to 8000 mg per serving) and various ratios of leucine, isoleucine, and valine amino acids (usually in a 2:1:1 ratio) in sports markets [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Videos about Branched-Chain Amino Acids Supplements on YouTube™: A Multi-Approach Study

Günalan

Turhan

Çavak

et al. 2022

IJERPH

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Branched-chain amino acids (BCAAs) are one of the most controversial ergogenic aids in terms of effectiveness and safety. This study aimed to evaluate the quality and reliability of BCAA supplements related to English videos on YouTubeä and to synthesize with the sentiment–emotion analysis of comments on videos. The content analysis of the information on videos was evaluated with the use of DISCERN, Journal of American Medical Association (JAMA) benchmark criteria, and Global Quality Score (GQS). In addition, word cloud and sentiment and emotional analysis of comments in videos were performed with the R package. As a result, the mean ± standard error values of DISCERN, JAMA, and GQS scores of all videos were 29.27 ± 1.97, 1.95 ± 0.12, and 2.13 ± 0.17, respectively. It was found that advertisement-free videos have a significantly higher DISCERN and GQS score than advertisement-included videos (p < 0.05). A moderately significant positive correlation was determined between DISCERN score of video content and the positive sentiment of video comments (rs: 0.400, p = 0.002). In conclusion, it was determined that BCAA-related YouTubeä videos have mostly very poor quality in terms of content and that videos with higher quality may receive positive comments from viewers according to the DISCERN instrument.

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Section: Introductionmentioning

confidence: 99%

The Evaluation of Videos about Branched-Chain Amino Acids Supplements on YouTube™: A Multi-Approach Study

Günalan

Turhan

Çavak

et al. 2022

IJERPH

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“…Controls were recruited during annual check-ups, and for the French subjects, additional controls were included from the GEHA (Genetics of Health Aging) project [ 32 ]. Patient’s data were recorded through a secure portal ( https://xz.univ-montp1.fr ) using the MEDIPAD software and were stored in Medigene, Anthropological & Genetic DataBase (MAGDB) [ 14 ]. For replication, we used an extended sample (n = 832) from Southern Europe ( Turkey , Italy , Greece and Spain ).…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies indicate that reduction of BCAA intake in a Western diet was sufficient to improve metabolic health, weight reduction, insulin sensitivity and to transiently induce secretion of the fibroblast growth factor 21 (FGF-21) [ 12 , 13 ]. Dietary intake of BCAA was also correlated with obesity in Mediterranean populations and with IR or T2D [ 14 – 16 ]. Other emerging data indicated that not only BCAA concentration per se but concomitant altered oxidative metabolism, particularly involving the muscle tissue, would be involved in IR [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation

et al. 2019

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Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development of diabetes. To define determinants of insulin resistance (IR) we investigated 73 genes involved in BCAA metabolism or regulation by fine-scale haplotype mapping in two European populations with metabolic syndrome. French and Romanians (n = 465) were genotyped for SNPs (Affymetrix) and enriched by imputation (BEAGLE 4.1) at 1000 genome project density. Initial association hits detected by sliding window were refined (HAPLOVIEW 3.1 and PHASE 2.1) and correlated to homeostasis model assessment (HOMAIR) index, in vivo insulin sensitivity (SI) and BCAA plasma levels (ANOVA). Four genomic regions were associated with IR located downstream of MUT, AACS, SLC6A15 and PRKCA genes (P between 9.3 and 3.7 x 10−5). Inferred haplotypes up to 13 SNPs length were associated with IR (e.g. MUT gene with P < 4.9 x 10−5; Bonferroni 1.3 x 10−3) and synergistic to HOMAIR. SNPs in the same regions were also associated with one order of magnitude lower P values (e.g. rs20167284 in the MUT gene with P < 1.27 x 10−4) and replicated in Mediterranean samples (n = 832). In French, influential haplotypes (OR > 2.0) were correlated with in vivo insulin sensitivity (1/SI) except for SLC6A15 gene. Association of these genes with BCAA levels was variable, but influential haplotypes confirmed implication of MUT from BCAA metabolism as well as a role of regulatory genes (AACS and PRKCA) and suggested potential changes in transcriptional activity. These data drive attention towards new regulatory regions involved in IR in relation with BCAA and show the ability of haplotypes in phased DNA to detect signals complimentary to SNPs, which may be useful in designing genetic markers for clinical applications in ethnic populations.

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“…In this population it was observed a lower incidence of COVID-19 in children and females compared to adults and males. While Iceland may represent an excellent model to understand genetics of COVID-19, the Mediterranean populations are by contrast more complicated since Mediterranean borders were places of admixed populations for millennia, including the admixture with North African populations (27)(28)(29). It is worth saying that analysis of genetic data triggering the MetS and its components from the MEDIGENE program ((https:// cordis.europa.eu/result/rcn/195753_fr.html) in the Mediterranean area would be of crucial importance.…”

Section: Host Geneticsmentioning

confidence: 99%

How Geneticists Contribute to Understanding of Covid-19 Disease Pathogenicity

Grigorescu

Lautier

2020

Acta Endo (Buc)

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Human populations are faced to the COVID-19 pandemic due to the emerging SARS-CoV-2 coronavirus originating from Wuhan (China) and with dramatic Public Health consequences. Despite periods of panic, the scientific community demonstrated an incredible innovation potential and energy ending up in one year with new vaccines to be used in population. Researchers are interrogating on how individual genetic differences contribute to the diversity of clinical manifestations or ethnic and geographic disparities of COVID-19. While efforts were spent to understand mechanistically the infectious potential of the virus, recent progresses in molecular genetics and bioinformatics allowed the characterization of viral sequence and construction of phylogeographical maps of viral dispersion worldwide. These data will help understanding epidemiological disparities among continents and ethnic populations. Much effort was also spent in analyzing host genetics by studying individual genes involved in innate and immune responses or explaining pathogenesis of comorbidities that complicate the fate of elderly patients. Several international consortia launched already Genome wide Association Studies (GWAS) and whole genome sequencing strategies to identify genetic markers with immediate application in patients at risk of respiratory failure. These new genetic data are important not only for understanding susceptibility factors for COVID-19 but they also contain an important message of hope for mankind warranting our survival and health.

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Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations

Cited by 5 publications

References 61 publications

The Evaluation of Videos about Branched-Chain Amino Acids Supplements on YouTube™: A Multi-Approach Study

The Evaluation of Videos about Branched-Chain Amino Acids Supplements on YouTube™: A Multi-Approach Study

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation

How Geneticists Contribute to Understanding of Covid-19 Disease Pathogenicity

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