Hierarchically Molecular Imprinted Porous Particles for Biomimetic Kidney Cleaning

Chen, Hanxu; Bian, Feika; Sun, Lingyu; Zhang, Dagan; Shang, Luoran; Zhao, Yuanjin

doi:10.1002/adma.202005394

Cited by 59 publications

(48 citation statements)

References 61 publications

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“…Compared to TPGDA/PAA, TPGDA/PAA-Urea had an increased weight loss region at about 90-190 • C, in which the weight of TPGDA/PAA-Urea lost only 3.47% more weight than TPGDA/PAA, and the weight degradation pattern in other temperature regions was approximately the same. Thus, the urea content adsorbed through the chemical chain was negligible [33].…”

Section: Properties Of Mispmentioning

confidence: 97%

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Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration

Zhang

Liu

et al. 2022

Nanomaterials

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Adsorption of urea from dialysate is essential for wearable artificial kidneys (WRK). Molecularly imprinted microspheres with nanoporous and multilayered structures are prepared based on liquid–liquid phase separation (LLPS), which can selectively adsorb urea. In addition, we combine the microspheres with a designed polydimethylsiloxane (PDMS) chip to propose an efficient urea adsorption platform. In this work, we propose a formulation of LLPS including Tripropylene glycol diacrylate (TPGDA), ethanol, and acrylic acid (30% v/v), to prepare urea molecularly imprinted microspheres in a simple and highly controllable method. These microspheres have urea molecular imprinting sites on the surface and inside, allowing selective adsorption of urea and preservation of other essential constituents. Previous static studies on urea adsorption have not considered the combination between urea adsorbent and WRK. Therefore, we design the platform embedded with urea molecular imprinted microspheres, which can disturb the fluid motion and improve the efficiency of urea adsorption. These advantages enable the urea absorption platform and are highly promising for dialysate regeneration in WRK.

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Section: Properties Of Mispmentioning

confidence: 97%

“…TPGDA/PAA, and the weight degradation pattern in other temperature regions was approximately the same. Thus, the urea content adsorbed through the chemical chain was negligible [33].…”

Section: Studies Of Urea Removal Of Mispmentioning

confidence: 97%

Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration

Zhang

Liu

et al. 2022

Nanomaterials

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“…Inspired by the self-purification ability of the kidney, Chen et al proposed a new adsorbent called molecular-imprinted polymer inverse opal particles (MIPIOPs) [ 54 ]. Here, the fluidic environment is used to resolve the dilemma of insufficient contact between adsorbent materials and targets molecules.…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

“…The resultant MIPIOPs possess multiple molecular binding sites for lysozyme at the surface, while the urea and creatinine are in the interior. The MIPIOPs have unique features and display good blood compatibility, and it has been demonstrated that their adsorption capacity is maintained stably after being reused for five times [ 54 ]. Moreover, due to highly ordered 3D porous structure, they are imparted with photonic band gap properties that allow for monitoring and self-reporting the state of adsorption.…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

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Recent trends in therapeutic application of engineered blood purification materials for kidney disease

et al. 2022

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Blood purification is a commonly used method to remove excess metabolic waste in the blood in renal replacement therapy. The sufficient removal of these toxins from blood can reduce complications and improve survival lifetime in dialysis patients. However, the current biological blood purification materials in clinical practice are not ideal, where there is an unmet need for producing novel materials that have better biocompatibility, reduced toxicity, and, in particular, more efficient toxin clearance rates and a lower cost of production. Given this, this review has carefully summarized newly developed engineered different structural biomedical materials for blood purification in terms of types and structure characteristics of blood purification materials, the production process, as well as interfacial chemical adsorption properties or mechanisms. This study may provide a valuable reference for fabricating a user-friendly purification device that is more suitable for clinical blood purification applications in dialysis patients. Graphical Abstract

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Biohybrid Response Microparticles Decorated with Trained‐MSCs for Acute Liver Failure Recovery

Wang

Huang

et al. 2022

Adv Healthcare Materials

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Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release. Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs. The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe 3 O 4 nanoparticles. Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way. Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity." Moreover, this process can be monitored in real-time by the structural color change of the MIOPs. With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs. These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.

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Hierarchically Molecular Imprinted Porous Particles for Biomimetic Kidney Cleaning

Cited by 59 publications

References 61 publications

Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration

Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

Biohybrid Response Microparticles Decorated with Trained‐MSCs for Acute Liver Failure Recovery

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