Hidradenitis Suppurativa is Associated with Symptoms of Keratoconjunctivitis Sicca

Schargus, Marc; Langhorst, Christine Anna; Joachim, Stephanie C; Фрингс, Андреас; Krause, Kristina; Reifenberger, Julia; Geerling, Gerd; Frings, Virginie

doi:10.1080/02713683.2020.1775259

Cited by 5 publications

(19 citation statements)

References 47 publications

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“…Of the 15 studies, four studies reported data on the prevalence of dry eye disease [14, 30, 33, 35]. According to the data from 555 people (303 psoriasis patients and 252 non-psoriasis controls), psoriasis patients showed a significantly higher prevalence of dry eye disease than the non-psoriasis controls (OR, 8.49, 95% CI, 3.34–21.58, p < 0.0001).…”

Section: Resultsmentioning

confidence: 99%

“…Although most of the included studies consented that patients with psoriasis are associated with dry eye disease, the results of the above examinations were quite variable. For example, while most of the included studies reported that patients with psoriasis had a lower Schirmer I test score, compared to non-psoriasis controls, some of the included studies revealed no significant changes [14, 27, 31]. As previous studies have shown the discrepancies between dry eye-related symptoms and different examination results, one single examination is not sufficient for the diagnosis of dry eye [45].…”

Section: Discussionmentioning

confidence: 99%

“…Zengin et al reported that patients with psoriasis had Meibomian gland dysfunction (MGD), including higher plugging and thickness indices, while Her et al found no significant MGD in psoriasis patients [25, 27]. Last, the reports regarding altered tear osmolality, which is involved in the pathogenesis of dry eye disease, in psoriasis patients has been largely inconsistent [14, 31, 42]. Although the study by Schargus et al found a tendency toward increased tear osmolality, another study by Demirci et al reported a significant association [14, 31].…”

Section: Discussionmentioning

confidence: 99%

“…Last, the reports regarding altered tear osmolality, which is involved in the pathogenesis of dry eye disease, in psoriasis patients has been largely inconsistent [14, 31, 42]. Although the study by Schargus et al found a tendency toward increased tear osmolality, another study by Demirci et al reported a significant association [14, 31].…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported increased levels of proinflammatory cytokines interleukin (IL)-17 and IL-22 in the tear film of patients with dry eye [49]. These cytokines are also crucial in the pathogenesis of psoriasis, and a significant increase in the tear film of patients with psoriasis was also demonstrated in the study by Schargus et al [14]. Further studies are needed to elucidate the relationship between the two conditions.…”

Section: Discussionmentioning

confidence: 99%

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Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Wu¹,

Ma²,

Huang³

et al. 2022

Dermatology

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Background: Psoriasis is a chronic inflammatory skin disease with potential systemic involvement. Some evidence suggests an increased risk of dry eye in patients with psoriasis. However, the relationship between these two conditions remains unclear. The aim of our study is to investigate the association between psoriasis and dry eye disease. Methods: This meta-analysis was registered in PROSPERO (CRD42020199445) and adhered to MOOSE checklist and PRISMA guidance for all processes. PubMed, Embase, Web of Science, and Cochrane databases were searched for studies examining the association between psoriasis and dry eye disease from inception to December 13, 2020. The primary outcome was the prevalence of dry eye disease in patients with psoriasis relative to controls. The secondary outcomes were the Schirmer I test score, tear film breakup time (TBUT), and ocular surface disease index (OSDI). The risk of bias of the selected studies was assessed using the Newcastle-Ottawa Scale. Results: The meta-analysis showed a significant association between dry eye disease and psoriasis (OR, 8.49; 95% CI, 3.34–21.58). Moreover, patients with psoriasis had a significantly lower Schirmer I test score (MD, −2.80; 95% CI, −4.07 to −1.52), shorter TBUT (MD, −4.12; 95% CI, −5.22 to −3.02), and higher OSDI (MD, 20.15; 95% CI, 6.24–34.05; p < 0.01), compared to controls. Conclusions: The current evidence supports an association between dry eye disease and psoriasis. These results suggest ophthalmologic assessment for the early recognition and management of dry eye in patients with psoriasis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Wu¹,

Ma²,

Huang³

et al. 2022

Dermatology

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Corneal Manifestations in Patients with Hidradenitis Suppurativa

Li,

Huang,

Chang

et al. 2024

Ocular Immunology and Inflammation

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Dry eye syndrome symptoms in patients with psoriasis

Nowowiejska,

Ordon,

Baran

et al. 2023

Acad Dermatol Venereol

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BackgroundPsoriasis is one of the most common dermatoses associated with a variety of comorbidities. There have been some reports on its possible association with ocular disorders however dry eye syndrome (DES) in such patients has been poorly investigated.ObjectivesTo investigate the frequency of DES symptoms in psoriatic patients, also regarding psoriasis severity in PASI, manifestation and therapy.Methods40 patients with psoriasis and 40 volunteers without dermatoses were enrolled in the study. They completed Ocular Surface Disease Index (OSDI) questionnaire and were objectively examined by IDRA® device to perform automatic interferometry, automatic meibography of lower eyelid glands, non‐invasive break‐up time (NIBUT), blink quality and tear meniscus height.ResultsPatients with psoriasis had statistically significantly thicker lipid layer (p = 0.0042 left eye, p = 0.0313 right eye) and greater loss of Meibomian glands compared to controls (p = 0.0128 left eye, p = 0.048 right eye). The patients had lower, although insignificantly, eye blink quality and tear meniscus height than the control group, as well as shorter NIBUT and higher score in OSDI. After the division of patients into two groups–with or without nails involvement/psoriatic arthritis/systemic treatment– we did not observe any significant differences between the groups. PASI did not correlate with any DES parameter.ConclusionsThis is the first study of DES symptoms with an objective IDRA® analyzer. We managed to observe that patients with psoriasis have thicker lipid layer and higher Meibomian glands' loss in lower eyelids. Based on all assessed objective and subjective parameters psoriatics do not seem to have an increased risk of DES. The presence of psoriatic arthritis or nail involvement does not seem to be a predisposing factor for DES development. PASI probably cannot be a prognostic factor for any of the DES‐associated parameters. Nevertheless, DES in psoriasis requires further research on bigger samples to establish reliable recommendations.

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Hidradenitis Suppurativa is Associated with Symptoms of Keratoconjunctivitis Sicca

Cited by 5 publications

References 47 publications

Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Corneal Manifestations in Patients with Hidradenitis Suppurativa

Dry eye syndrome symptoms in patients with psoriasis

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