Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Abstract

<b><i>Background:</i></b> Psoriasis is a chronic inflammatory skin disease with potential systemic involvement. Some evidence suggests an increased risk of dry eye in patients with psoriasis. However, the relationship between these two conditions remains unclear. The aim of our study is to investigate the association between psoriasis and dry eye disease. <b><i>Methods:</i></b> This meta-analysis was registered in PROSPERO (CRD42020199445) and adhered to MOOSE checklist and PRISMA guidance for all processes. PubMed, Embase, Web of Science, and Cochrane databases were searched for studies examining the association between psoriasis and dry eye disease from inception to December 13, 2020. The primary outcome was the prevalence of dry eye disease in patients with psoriasis relative to controls. The secondary outcomes were the Schirmer I test score, tear film breakup time (TBUT), and ocular surface disease index (OSDI). The risk of bias of the selected studies was assessed using the Newcastle-Ottawa Scale. <b><i>Results:</i></b> The meta-analysis showed a significant association between dry eye disease and psoriasis (OR, 8.49; 95% CI, 3.34–21.58). Moreover, patients with psoriasis had a significantly lower Schirmer I test score (MD, −2.80; 95% CI, −4.07 to −1.52), shorter TBUT (MD, −4.12; 95% CI, −5.22 to −3.02), and higher OSDI (MD, 20.15; 95% CI, 6.24–34.05; <i>p</i> < 0.01), compared to controls. <b><i>Conclusions:</i></b> The current evidence supports an association between dry eye disease and psoriasis. These results suggest ophthalmologic assessment for the early recognition and management of dry eye in patients with psoriasis.

Ocular complications in adults with psoriasis: a cross-sectional study in a referral center in Brazil

“…Commonly known ocular effects of retinoids include DED, eye irritation, and blepharoconjunctivitis, although eyelash loss and pseudotumor cerebri syndrome have also been described [ 3 ]. This supports the hypothesis that DED in patients with psoriasis may be due to the chronic inflammatory disease itself and/or lacrimal film instability [ 32 ]. A previous study reported no association between DED and most therapies, except for an unexpected association with the previous use of coal tar ( p < 0.05) [ 4 ].…”

Interleukin-17A-Correlated Myocarditis in Patients with Psoriasis: Cardiac Recovery following Secukinumab Administration

“…PS is an immune-mediated inflammatory disease with prevalent skin involvement. Indeed, a systemic spreading of the disease has been recognized with possible extension to joints [ 17 ], aorta [ 18 ] and eye [ 19 ]. Myocardial inflammation has been previously suggested in the setting of dilated cardiomyopathy manifesting in subjects with PS, but histologic confirmation as well as pathogenetic correlations with the former disease have not been provided so far.…”