Heterogeneity in cognitive functioning among patients with bipolar disorder

Martino, Diego Javier; Strejilevich, Sergio; Scápola, María; Igoa, Ana; Marengo, Eliana; Ais, Ezequiel D.; Perinot, Lila

doi:10.1016/j.jad.2007.12.232

Cited by 143 publications

(130 citation statements)

References 26 publications

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“…Two previous studies by Depp et al (2008) and Balanza-Martinez et al (2005) did not detect any differential age-related decline in middleaged BD patients assessed longitudinally over a period of 3 years and between 1 and 3 years, respectively. However, others reported a more rapid cognitive decline in middle-aged and older BD patients compared to healthy controls (Dhingra and Rabins, 1991;Gildengers et al, 2009) pointing to the marked heterogeneity of cognitive profiles in BD (Martino et al, 2008b). In the present series, BD patients were free from lifetime psychiatric comorbidities such as substance abuse that are known to influence cognition (Liappas et al, 2007;Levy et al, 2008).…”

Section: Discussionmentioning

confidence: 50%

Longitudinal analysis of cognitive performances and structural brain changes in late‐life bipolar disorder

Delaloye

Moy

Bilbao

et al. 2011

Int J Geriat Psychiatry

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Section: Discussionmentioning

confidence: 50%

Longitudinal analysis of cognitive performances and structural brain changes in late‐life bipolar disorder

Delaloye

Moy

Bilbao

et al. 2011

Int J Geriat Psychiatry

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“…This is a frequent and special concern among BD patients although few studies reported a correlation between medication use and cognitive performance. Previously, a study observed a negative influence over verbal memory by mood stabilizers and impairments in psychomotor speed, attention, and executive function with the use of benzodiazepines 5 . However, another study did not find any correlation with a particular class of medication 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Meta-analytical data yielded executive and verbal memory impairments as the most common cognitive deficits in BD patients without dementia 3,4 . Cognitive functions such as attention, visual memory, mental speed, language and, to a lesser extent, visuospatial function were also implicated within the spectrum of cognitive dysfunction of these patients 5,6,7 . Cognition seems to be similarly impaired in BD across the life span 8 , and geriatric BD patients also show a similar pattern of widespread cognitive dysfunction 9 .…”

mentioning

confidence: 97%

The use of the Clock Drawing Test in bipolar disorder with or without dementia of Alzheimer’s type

Aprahamian

Radanovic

Nunes

et al. 2014

Arq. Neuro-Psiquiatr.

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There is limited data regarding the cognitive profile from screening tests of older adults with bipolar disorder (BD) with dementia. Objective: To investigate the Clock Drawing Test (CDT) among older adults with BD with and without Alzheimer's disease (AD). Method: 209 older adults (79 with BD without dementia and 70 controls; 60 with AD, being 27 with BD) were included to evaluate the performance of three CDT scoring scales, beyond the Mini-Mental State Examination (MMSE) and verbal fluency (VFT). Results: Patients with BD without dementia presented with lower scores in MMSE, VF and one CDT scoring scale than controls. Patients with BD and AD presented with lower scores in VF and CDT scoring scales than patients with only AD. All CDT scales presented similar sensitivity and specificity for BD and non-BD groups. Conclusion: Elderly subjects with BD showed greater impairment in CDT in both groups of normal cognition and AD.Keywords: Clock Drawing Test, Alzheimer's disease, bipolar disorder. RESUMOHá dados limitados sobre o perfil cognitivo de idosos com transtorno bipolar (TAB) e demência. Previamente, testes de rastreio cognitivo comuns foram pouco estudados. Objetivo: Investigar o Teste do Desenho do Relógio (CDT) entre idosos com TAB com e sem doença de Alzheimer (DA). Método: Foram incluídos 209 idosos (79 pacientes com TAB sem demência e 70 controles; 60 indivíduos com DA leve, sendo 27 com TAB) para avaliar três escalas de pontuação do TDR, além do Mini-Mental State Examination (MMSE) e fluência verbal (FV). Resultados: Pacientes com TAB sem demência apresentaram menores escores no MMSE, FV e uma escala de TDR que controles. Pacientes com TAB e DA apresentaram escores mais baixos na FV e em todos os TDR comparados aos apenas com DA. As escalas de CDT apresentaram sensibilidade e especificidade semelhantes para os grupos com e sem TAB. Conclusão: Idosos com TAB apresentaram maior comprometimento no TDR em ambos grupos com cognição normal e DA.Palavras-chave: Teste do Desenho do Relógio, doença de Alzheimer, transtorno bipolar.

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“…One quarter to one third of individuals with schizophrenia demonstrate ''normal'' neurocognitive performance within the average range (Palmer et al, 1997;Rund et al, 2006). Those with affective disorders are even more likely to have abilities in the normal range*around 70% of individuals with unipolar depression (Iverson, Brooks, Langenecker, & Young, 2011;Rund et al, 2006) and around 60% of those with bipolar disorder (Iverson et al, 2011;Martino et al, 2008). Potentially, individuals with these illnesses who present with neurocognitive impairments are experiencing a different underlying disease process.…”

mentioning

confidence: 99%

“…Potentially, individuals with these illnesses who present with neurocognitive impairments are experiencing a different underlying disease process. In both schizophrenia and bipolar disorder there are demographic and clinical differences between those with impaired and intact neurocognitive performance in schizophrenia and bipolar disorder (Martino et al, 2008;Palmer et al, 1997), suggesting that this concept may have merit.…”

mentioning

confidence: 99%