Cognitive precursors of severe mental disorders

Wood, Stephen J.; Yung, Alison R.; Pantelis, Christos

doi:10.1080/13546805.2012.750439

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…In particular, accumulating research suggests that maternal stress during pregnancy is related to childhood cognitive difficulties frequently seen in the histories of depressed populations (Hofstra et al, 2002; Wood et al, 2013), such as lower scores on tests of intellectual functioning and language abilities (Laplante et al, 2008; Slykerman et al, 2005), problems of attention/concentration (Brouwers et al, 2001; Gutteling et al, 2006), and difficultites in academic performance (Niederhofer and Reiter, 2004). Additionally, prenatal maternal stress has been associated with increases in offspring behavioral/emotional problems during childhood that are linked to risk of later depression (Zahn-Waxler et al, 2000), such as childhood anixety (Davis and Sandman, 2012; Loomans et al, 2011), parental report of behavioral maladjustment (Gutteling et al, 2005; O'Connor et al, 2002), internalizing problems (Howland et al, 2016; Park et al, 2014), and temperaments associated with increased frustration, crying, and negative reactivity (Davis et al, 2007; Gutteling et al, 2005; Werner et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Maternal infection and stress during pregnancy and depressive symptoms in adolescent offspring

Murphy

Fineberg

Maxwell

et al. 2017

Psychiatry Research

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Maternal infection during pregnancy has been linked to increased risk of offspring depression. Additionally, maternal stress during pregnancy has been consistently linked with adverse offspring outcomes associated with depression. Relatedly, stress has been associated with increased risk of infection; however no study has investigated stress-infection interactions during pregnancy and risk for offspring depression. Participants were drawn from the Child Health and Development Study (CHDS), a prospective, longitudinal study that enrolled pregnant women from 1959-1966. Maternal health and birth outcome information were collected, as well as open-ended interviews about worrisome events during pregnancy. The present study included participants from a subsample of women whose offspring (n = 1,711) completed self-reports of depressive symptoms during adolescence. Results indicated that maternal infection during only the second trimester was associated with higher scores on adolescent offspring depressive symptoms, while controlling for maternal education at birth, adolescent age, and maternal depressive symptoms at adolescence. Maternal experiences of daily stress during pregnancy moderated this association, such that mothers diagnosed with second trimester infection and who experienced daily stress had offspring with significantly higher depression scores than mothers of adolescents diagnosed with an infection alone. Findings have potential implications for prevention and intervention strategies.

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Section: Introductionmentioning

confidence: 99%

Maternal infection and stress during pregnancy and depressive symptoms in adolescent offspring

Murphy

Fineberg

Maxwell

et al. 2017

Psychiatry Research

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“…Secondly, by adding an early description of the individual's risk of progression to a specific illness stage, it may help the clinician to estimate the value of performing a specific investigation or to make utility-based judgments on treatment selection, thus personalizing the assessment and treatment process and optimizing overall efficiency of care (Hatcher, 1995;Owens et al, 1997;Simon et al, 2006;Sox et al, 2013;Werneke et al, 2012;Yokota and Thompson, 2004). Treatment choices informed by such risk may, for example, involve early clozapine initiation (Kaneda et al, 2010;Remington et al, 2013), targeted early provision of cognitive remediation training or cognitive enhancing treatments (Koike et al, 2013;Medalia and Saperstein, 2013;Wood et al, 2013), early specialized vocational rehabilitation (Killackey et al, 2008), specific neuroprotective strategies (Swerdlow, 2011), or targeted augmentation with anti-inflammatory medications (Sommer et al, 2014) or metabolic modifiers such as metformin (Correll et al, 2013;Guest et al, 2013aGuest et al, 2013b.…”

Section: Implications For Clinical Practicementioning

confidence: 99%

The use of clinical and biological characteristics to predict outcome following First Episode Psychosis

Schubert

Clark

Baune

2014

Aust N Z J Psychiatry

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Objective: Psychotic illnesses such as schizophrenia and other non-affective psychoses are heterogeneous in disease course and functional outcomes. We review evidence from investigations in clinical psychiatry, neuroimaging, neurocognition, and blood biomarker research suggesting that distinct bio-psycho-social patterns exist at the onset and during the early phase of a First Episode Psychosis (FEP), which can describe the risk of individual illness progression and functional trajectories.Method: A selective literature review was performed on articles drawn from Medline searches for relevant key words. A simulation model was constructed from data derived from two recent publications, selected as examples of studies that investigated multivariate predictors of long-term outcome following FEP. Results:We illustrate how illness trajectories following FEP could be described based on multimodal sociodemographic, clinical, psychological, and neurobiological information. A clinical modeling simulation shows that risk trajectories for achieving long-term favorable or unfavorable outcomes can differ significantly depending on baseline characteristics in combination with MRI and functional measurements within 6 months of disease onset. Conclusions:Multimodal trajectory modeling may be useful to describe longitudinal outcomes following FEP. Rich longitudinal data on predictors and outcomes, and better integration of multimodal (sociodemographic, clinical, psychological, biological) data, are required to operationalize this approach. This technique may improve our understanding of course of illness and help to provide a more personalized approach to the assessment and treatment of people presenting with FEP.

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“…Low birth weight in infants is linked to chronic maternal stress, racism exposure, and depressive symptoms during pregnancy [ 72 ]. Accumulating research indicates that prenatal stress and depression during pregnancy are associated with cognitive and academic performance difficulties [ 73 ]. Maternal anxiety during pregnancy is associated with subsequent infant development, increased risk of behavioral/emotional disorders, and depression later in children [ 74 ].…”

Section: Early Life Adverse Exposure and Future Disease Riskmentioning

confidence: 99%

The Potential Role of PPARs in the Fetal Origins of Adult Disease

Guo

et al. 2022

Cells

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The fetal origins of adult disease (FOAD) hypothesis holds that events during early development have a profound impact on one’s risk for the development of future adult disease. Studies from humans and animals have demonstrated that many diseases can begin in childhood and are caused by a variety of early life traumas, including maternal malnutrition, maternal disease conditions, lifestyle changes, exposure to toxins/chemicals, improper medication during pregnancy, and so on. Recently, the roles of Peroxisome proliferator-activated receptors (PPARs) in FOAD have been increasingly appreciated due to their wide variety of biological actions. PPARs are members of the nuclear hormone receptor subfamily, consisting of three distinct subtypes: PPARα, β/δ, and γ, highly expressed in the reproductive tissues. By controlling the maturation of the oocyte, ovulation, implantation of the embryo, development of the placenta, and male fertility, the PPARs play a crucial role in the transition from embryo to fetus in developing mammals. Exposure to adverse events in early life exerts a profound influence on the methylation pattern of PPARs in offspring organs, which can affect development and health throughout the life course, and even across generations. In this review, we summarize the latest research on PPARs in the area of FOAD, highlight the important role of PPARs in FOAD, and provide a potential strategy for early prevention of FOAD.

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Cognitive precursors of severe mental disorders

Cited by 5 publications

References 48 publications

Maternal infection and stress during pregnancy and depressive symptoms in adolescent offspring

Maternal infection and stress during pregnancy and depressive symptoms in adolescent offspring

The use of clinical and biological characteristics to predict outcome following First Episode Psychosis

The Potential Role of PPARs in the Fetal Origins of Adult Disease

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