Heterocyclic compounds bearing pyrimidine, oxazole and pyrazole moieties: design, computational, synthesis, characterization, antibacterial and molecular docking screening

Arshad, Mohammad

doi:10.1007/s42452-020-2243-0

Cited by 12 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S C H E M E 1 Synthesis of compound 2 [41] sulfonamide containing pyrimidine derivatives from chalcone 3 as an intermediate [66].…”

Section: Different Synthetic Strategies Of Pyrimidinesmentioning

confidence: 99%

A review on pyrimidine‐based derivatives: Synthesis and their biological application

Islam,

Akter

et al. 2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

Pyrimidine‐based derivatives have attracted a lot of interest in heterocyclic chemistry due to its versatile structure and diverse biological activities. This study provides a comprehensive overview of synthetic strategy of different pyrimidine ring and highlights their biological importance. In this article, we start off by going through the fundamental procedures for the synthesis of pyrimidine scaffolds, including both conventional and contemporary synthetic techniques. These works cover a range of therapeutic domains, such as effects that are anticancer, antibacterial, antiviral, anti‐inflammatory, antioxidant, antimalarial, and so on. Moreover, we have summarized with a discussion of future prospects and challenges in the field of pyrimidine heterocyclic chemistry. This thorough review is a significant resource for researchers in medicinal chemistry and related fields since it offers insightful information about the synthetic methods and biological applications of pyrimidine‐based derivatives.

show abstract

“…S C H E M E 1 Synthesis of compound 2 [41] sulfonamide containing pyrimidine derivatives from chalcone 3 as an intermediate [66].…”

Section: Different Synthetic Strategies Of Pyrimidinesmentioning

confidence: 99%

A review on pyrimidine‐based derivatives: Synthesis and their biological application

Islam,

Akter

et al. 2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

“…Likewise, the imidazole ring is amphoteric five membered scaffold comprising two N heteroatoms in the system and readily bind with diverse enzymes and receptors via weaker interactions such as ion‐dipole, coordination bonds, van der waal force, hydrogen bonds, and hydrophobic effect etc [6] . In addition, the incorporation of six membered pyridine with aforementioned five membered heterocyclic azole units lead to biologically active organic molecules with diverse biological activities [5a–c,7] . Thus, there is intense need for the development of cost effective and more efficient antimicrobial drugs with lower side effects.…”

Section: Introductionmentioning

confidence: 99%

Bis(azolyl)pyridine‐2,6‐dicarboxamide Derivatives: Synthesis, Bioassay Analysis and Molecular Docking Studies

kumar

Hariprasad

Joshi³

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

A new class of bis(azolyl) pyridine‐2,6‐dicarboxamides based derivatives were designed and synthesized by employing ultrasonication methodology. In this work, we studied the role of different heteroaromatic azole units such as oxazole, thiazole and imidazole moieties along with different donating/withdrawing substituents on the pyridine scaffold and anticipated to display good biological activities. The detailed molecular docking studies validates the antimicrobial activities of these targeted molecules. Further, to evaluate their antioxidant properties, the target compounds were exposed to three different invitro free radical scavenging assay methods. Further, using the disc diffusion method, the targeted molecules were screened for invitro antibacterial activities against the pathogenic stains. Besides, the targeted molecules were also tested against A. niger and P. chrysogenum strains to assess their antifungal activity. The screening results reveals that, the most of the compounds form the series demonstrating reasonable to decent antioxidant and antimicrobial activities against pathogenic stains in comparison with the standard drug.

show abstract

“…Imidazole and its derivatives play a vital role in pharmaceutical and biological molecules, including ketoconazole, biotin, histidine, histamine, miconazole, clotrimazole, Olmesartan, losartan, and fluconazole [7] . In addition, the combination of six membered pyrimidine with aforesaid five membered heterocyclic azole units lead to biologically active organic molecules with diverse biological activities [6a–b,8] …”

Section: Introductionmentioning

confidence: 99%

Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies

Kumar,

Hariprasad,

Joshi

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

We present a study on a new class of Schiff bases with pyrimidine linked hydrazinyl azole backbone. These compounds were synthesized using conventional and ultrasonication methods. Our design strategy incorporated three heteroaromatic azoles and various substituents on the pyrimidine scaffold to enhance antimicrobial properties. Antibacterial and antifungal screenings were conducted against specific pathogens, and molecular docking studies supported the results. The compounds exhibited significant antimicrobial activities, particularly against K. pneumoniae, surpassing the standard drug. These Schiff bases hold promise as potential antimicrobial agents.

show abstract

Heterocyclic compounds bearing pyrimidine, oxazole and pyrazole moieties: design, computational, synthesis, characterization, antibacterial and molecular docking screening

Cited by 12 publications

References 41 publications

A review on pyrimidine‐based derivatives: Synthesis and their biological application

A review on pyrimidine‐based derivatives: Synthesis and their biological application

Bis(azolyl)pyridine‐2,6‐dicarboxamide Derivatives: Synthesis, Bioassay Analysis and Molecular Docking Studies

Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies

Contact Info

Product

Resources

About