Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies
Momidi Bharath Kumar,
Vanam Hariprasad,
Shrinivas D Joshi
et al.
Abstract:We present a study on a new class of Schiff bases with pyrimidine linked hydrazinyl azole backbone. These compounds were synthesized using conventional and ultrasonication methods. Our design strategy incorporated three heteroaromatic azoles and various substituents on the pyrimidine scaffold to enhance antimicrobial properties. Antibacterial and antifungal screenings were conducted against specific pathogens, and molecular docking studies supported the results. The compounds exhibited significant antimicrobia… Show more
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