The use of photocatalyst for the degradation of synthetic and organic pollutants such as dyes and chemicals has emerged as an effective method for the waste water treatment. In this...
The term epilepsy is a collective term that includes disorders of the brain function characterized by the periodic and unpredictable occurrence of seizures. Epilepsies are common and frequently devastating and affect around 1-2 % of the world population (1).Current drug therapy for epilepsy suffers from a number of disadvantages, including the fact that the convulsions of approximately 25 % of epileptics are inadequately controlled by medication (2). In recent years, the field of antiepileptic drug development has become quite dynamic, affording many promising research opportunities.In our previous study (3-5), we designed aryl-substituted semicarbazones with benzothiazole moiety, in which we made some modifications in the structure of semicarbazones. The lipophilic aryl ring was replaced with a versatile heterocyclic molecule ben- Various,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100 % indicative of the promising nature of the compounds against seizure spread. Compounds 5b and 5c showed complete protection against MES induced seizures.
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