Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats

Abstract

Many traditional systems of medicines employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of ‘ethanolic extract of Aquilaria agallocha (沉 香Chen Xiang) leaves' (AAE) against paracetamol (PCM) induced hepatotoxicity in SD rats. Group I animals were treated with 1% CMC for 8 days. Group II, III, IV and V animals were first treated with ‘1% CMC’ 1 ml/kg/day, AAE 200 mg/kg/day, AAE 400 mg/kg/day and silymarin 100 mg/kg/day respectively for 7 days and then, orally administered with PCM 3 g/kg b. wt. on 8th day in a single dose. 24 h after the last dosing by PCM, the blood was obtained through the retro-orbital plexus under light anesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as ALT, AST, ALP, LDH, bilirubin, cholesterol, TP and ALB. Group IV rats showed significant (p < 0.01) decrease in ALT, AST, ALP, LDH, cholesterol, bilirubin, liver wt. and relative liver wt. levels while significant (p < 0.01) increase in final b. wt., TP and ALB levels as compared to group II rats. Hepatoprotective potential of AAE 400 mg/kg/day was comparable to that of standard drug silymarin 100 mg/kg/day. Results of the study were well supported by the histopathological observations. This study confirms that AAE possesses hepatoprotective potential comparable to that of standard drug silymarin as it exhibited comparable protective potential against PCM induced hepatotoxicity in SD rats.

Antioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in Rats

“…Active paracetamol and silymarin were purchased from SQUARE pharmaceutical Ltd. Dhaka, Bangladesh. Silymarin was used as a herbal standard since it has a reputed hepatoprotective effect (Alam et al, 2017). All chemicals and reagents used in this study were of analytical grade.…”

Chemical constituents and toxicity effects of leaves from several agarwood tree species (Aquilaria)

“…The A. crassna leaves have been used as supplements to combat various health conditions such as high blood pressure, constipation, headache and diabetes, and to treat digestive ailment and as a mild sedative (Kakino et al 2010, Pranakhon et al 2011. Generally, Aquilaria leaves reportedly contain various chemical compounds (Adam et al 2017) that are related to beneficial pharmacological properties such as anti-arthritic (Rahman et al 2016), anti-inflammatory , Qi et al 2009, Feng et al 2011), anticancer (Nie et al 2009, Zhong et al 2014), antitumor (Wei & Bin 2011), antioxidant (Han & Li 2012, Duan et al 2015, Simatupang et al 2015, antibacterial (Khalil et al 2013), antifungal (Chen et al 2014, antidiabetic (Feng et al 2011, Pranakhon et al 2011, Said et al 2016) lipid-lowering (Wu et al 2012), laxative (Kakino et al 2010, Li et al 2013, acetylcholinesterase (AChE) inhibitory (Bahrani et al 2014) and hepatoprotective (Alam et al 2017).…”

Hepatoprotective Effect of Citrus sinensis (L.) Osbeck Ethanol Extract in Paracetamol-Induced Rats

“…The following figure depicts the metabolism of paracetamol. 1,9,10 Evaluation of liver injury can be performed using some techniques, one of the them is by measuring biochemical serum indicators. These biochemical serum indicators include ALT and AST.…”