Antioxidant Properties and Dose-Dependent Effects of Monkey Fruits (<i>Artocarpus lakoocha</i>) against Paracetamol-Induced Hepato-Renal Toxicity in Rats

Ali, Md. Yousuf; Morshed, Md Reaz; Hossen, Md. Sakib; Tanvir, E. M.; Kabir, Amin Lutful; Islam, Md. Aminul; Karim, Nurul; Alam, Nadia; Khalil, Md. Ibrahim; Gan, Siew Hua

doi:10.3844/ajptsp.2018.16.29

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…While previous study of Ali et al, (21) that the paracetamol administration did cause significant increase in the average liver weight . These results are in acceptance with those obtained by other investigators (22) . These enzymes are originally present in the cytoplasm, when there is hepatopathy, these enzymes and molecules leak into the blood stream and serve as an indicator for the liver damage (23) .…”

Section: Discussionsupporting

confidence: 94%

Biochemical and Histopathological effects of Acetaminophen and Protective Effects of Naringin on Liver Rats

Aryaf Mahmood Sabea,

Ahlam J. H. AlKhamas,

Bashar Sabah Sahib

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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This study was conducted to find out liver protective activity of naringin (NRG) 40-80 mg/kg body weight (b.w.) against acetaminophen (ACN) 2g/kg induced liver damage in rats. Thirty two male rats were divided into four groups : group1: negative control, (1 ml/kg Saline orally) group II: positive control ACN (2g/ kg), orally as single dose at first day, group III: ACN (2g/kg), orally as single dose at first day , plus NRG (40 mg//kg) orally for (8) consecutive days, group IV: ACN (2g/kg), orally as single dose at first day , plus NRG (80 mg//kg) orally for (8) consecutive days. All the rats were anesthetized to collect blood then killed on the (9) day of the experiment to take the liver samples. ACN induced liver damage was proved by a significant (P<0.01) reduction in the body weight , total protein (TP) , albumin (AB) , superoxide dismutase (SOD) and catalase (CAT) enzymes and a significant (P<0.01) increased in liver weight, serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), direct bilirubin (DB) , malondialdehyde enzyme (MAD) and histopathological changes. Protective liver toxicity effect and oxidative damage caused by ACN significantly (P<0.01) increasing in body weight, TP, AB ,SOD and CAT and significantly (P<0.01) decreasing in liver weight , AST, ALT, ALP, TB, DB and MAD and improving tissue morphology by a meliorative in NRG 40 , 80 mg/kg b.w. These results confirm that NRG antioxidant effects can protect ACN induced hepatic toxicity in rats.

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Section: Discussionsupporting

confidence: 94%

Biochemical and Histopathological effects of Acetaminophen and Protective Effects of Naringin on Liver Rats

Aryaf Mahmood Sabea,

Ahlam J. H. AlKhamas,

Bashar Sabah Sahib

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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“…Furthermore, compared to the paracetamol-controlled group, there was a substantially higher total protein and highdensity lipoprotein cholesterol level. Histopathological results and decreased LPO peroxidation in the liver and kidneys further supported the hepatoprotective benefits (61).…”

Section: Reports On Silymarin's Nephroprotective Impact In Paracetamo...mentioning

confidence: 62%

The Protective Effect of Milk Thistle Against Drug-Induced Renal Illnesses: A Review

Abed¹,

Khalaf²,

Alnori³

2022

IJP

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Introduction: Nephrotoxicity is one of the most frequent kidney problems and happens when the body becomes exposed to medicine or toxin. Because renal tubular cells have metabolic activities, nephrotoxin can produce toxic components and cause damage. Paracetamol drug is safe when taken in therapeutic doses as an antipyretic and analgesic agent but its excessive doses may result in life-threatening renal impairment due to the generation of reactive-toxic metabolites. Scientific efforts are concentrated on discovering preventative or therapeutic medications to shield against the toxicity brought on by paracetamol due to nephrotoxicity. Silymarin, a medicine, is extracted from polyphenolic compounds found in the milk thistle plant. This plant has antioxidant, antiinflammatory, anti-cancerous, and other properties and is the most commonly used drug for hepatic illnesses. Also, it has renal-protecting effects. Objective: This review research highlights the nephroprotective of silymarin against paracetamol-induced renal damage.

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“…Antioxidants can be made in a lab or they can be found in nature. Synthetic antioxidants work well but they are not always safe [ 34 ]. Natural antioxidants are safe to grow because they are not contaminated with chemicals [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

A Literature Review of Artocarpus lacucha Focusing on the Phytochemical Constituents and Pharmacological Properties of the Plant

et al. 2022

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Studies have shown that approximately two-thirds of the plant species in the world have some medicinal value. Artocarpus lakoocha is a synonym for Artocarpus lacucha and is a plant that can be found in Indonesia. This medicinal plant has been used to treat many diseases. (1) Objective: This article discusses the scientific investigations carried out on A. lacucha, namely the plant’s chemical content, pharmacological activity, and active compounds. (2) Methods: The design of this study was based on an article that was a review of previous research. A search for relevant publications over the past ten years (2012–2022) using data from Pubmed, Proquest, Ebsco, ScienceDirect, and Google Scholar resulted in the discovery of 369 articles. (3) Results: Fifty relevant articles investigate A. lacucha’s substances and their applications in the health field. The presence of secondary metabolites and bioactive compounds has been reported, which is evidence that A. lacucha possesses antidiarrheal, immunostimulant, anticholesterol, and hepatoprotective agents. (4) Conclusions: Mobe (A. lacucha) is a plant native to North Sumatra, Indonesia. This plant is efficacious as an antioxidant, antibacterial, antidiarrheal, anti-inflammatory, analgesic, antinociceptive, schistosomicidal, hepatoprotective, neuroprotective, cytotoxic, antiglycation, and anticholesterol, and can also be used for anti-aging and wound healing. In addition to its various benefits, it turns out that this plant also has many active compounds that are useful to the health sector, especially the pharmaceutical field.

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Antioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in Rats

Abstract: This open access article is distributed under a Creative Commons Attribution (CC-BY) 3.0 license.

Cited by 3 publications

References 35 publications

Biochemical and Histopathological effects of Acetaminophen and Protective Effects of Naringin on Liver Rats

Biochemical and Histopathological effects of Acetaminophen and Protective Effects of Naringin on Liver Rats

The Protective Effect of Milk Thistle Against Drug-Induced Renal Illnesses: A Review

A Literature Review of Artocarpus lacucha Focusing on the Phytochemical Constituents and Pharmacological Properties of the Plant

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