Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Jacob, Jenson; Olaleye, Mary Tolulope; Olugbuyiro, J.A.O

doi:10.3126/ijasbt.v2i2.10473

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Phytochemicals found in A. cordifolia leaves include tannins, phenolic acids, flavonoids, and alkaloids, according to other studies [15,16,18]. The presence of flavonoids and tannins in the current study may have contributed to the antioxidant effect observed.…”

Section: Discussionsupporting

confidence: 72%

Protective effect of Alchornea cordifilia leaf extract on carbon tetrachloride-induced liver damage in Wistar rats

SI¹,

BM²,

Akoko³

et al. 2022

GSC Biol. and Pharm. Sci.

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The effect of aqueous extract of the leaves of Alchornea cordifolia on Carbon tetrachloride (CCl4)-induced liver damage was investigated in experimental rats. Treatment of separate groups of rats with 100mg/kg, 150mg/kg and 200mg/kg aqueous leaf extracts of Alchornea cordifolia for 2 weeks after establishment of CCl4 induced liver damage, resulted in significantly (P<0.05) less hepatotoxicity when compared to the CCl4-induced group, as measured by serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. The effect of extract was statistically significant (P<0.05) and was dose dependent. Histopathological study also showed significant reduction and even reversal of liver damage in the rats. The results of this study show that aqueous leaf extract of Alchornea cordifolia has a potent anti-hepatotoxic action against CCl4 induced liver damage in rats.

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Section: Discussionsupporting

confidence: 72%

Protective effect of Alchornea cordifilia leaf extract on carbon tetrachloride-induced liver damage in Wistar rats

SI¹,

BM²,

Akoko³

et al. 2022

GSC Biol. and Pharm. Sci.

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“…The microphotography of rat livers that received the extracts alone did not show any biochemical parameter disturbances. The results of this study were in agreement with the study of Jacob et al (2014), [9] in which A. cordifolia attenuated hepatocellular lesions induced by paracetamol at high doses. However, Ajibade and Olayemi (2015) [19] showed that methanolic extract of A. cordifolia, administered alone at doses of 800 mg/kg and 1600 mg/kg for 8 consecutive days, caused hepatocellular damage.…”

Section: Discussionsupporting

confidence: 93%

“…Indeed, A cordifolia was harvested for this study in its natural environment in Côte d'Ivoire while Ajibade and Olayemi (2015) [19] harvested it in a botanical garden in Nigeria. It was the same case with the plant studied by Jacob et al (2014) [9] which was harvested in its natural environment on uncultivated agricultural land. Protective effects against hepatocellular damage were observed with the methanolic extract of A. cordifolia at doses of 400 mg/kg and 800 mg/kg, as well as with the aqueous extract at a dose of 800 mg/kg.…”

Section: Discussionmentioning

confidence: 69%

“…For the time being, conventional medicine provides very few drugs that could effectively protect liver against hepatitis induced drug, scientific studies were conducted for novel natural hepatoprotective substances. For this purpose, several medicinal plants like Alchornea cordifolia were investigated [5][6][7] which methanolic and ethanol extracts showed hepatoprotective properties in an hepatotoxicity induced animal model using high dose of paracetamol or carbon tetrachloride [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Alcornea cordifolia Aqueous and Methanolic Leaf Extracts against Antituberculosis Drugs Induced Liver Damage in Rats

Etienne¹

2021

Int J Pharm Pharmacol

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The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with a high dose of paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent a risk factor for hepatotoxicity, could A. cordifolia play a key role to limit their hepatotoxicity? The objective of this study was to assess the histological changes of antituberculosis drugs in rat livers and their evolution after administration of an aqueous and a methanolic leaf extracts of A. cordifolia and therefore estimate their polyphenol and flavonoid contents. Rats were divided into three (3) groups: group 1 was treated with isoniazid; group 2 received the combination of isoniazid and rifampicin and group 3 was given the combination of isoniazid, rifampicin and pyraziamide. For each group of rats, the hepatotoxicant was either administered alone or two hours before administration of an aqueous (200, 400, or 800 mg/kg) or a methanolic (200, 400, or 800 mg/kg) leaf extracts of A. cordifolia each day for 10 days. Animals were sacrificed on day 11 and their livers removed for histolopathological analysis. In addition, total polyphenol and flavonoid contents were estimated in both extracts. Antituberculosis drug combinations caused peliosis lesions, steatosis and hepatocyte necrosis. The liver histology of rats that received extracts after administration of antituberculosis drug combinations showed the ability of extracts to annihilate or alleviate hepatocellular damage caused by such drugs. The methanolic extract, richer in total polyphenols (0.55 ± 0.02 mg EGA) than the aqueous extract (0.35 ± 0.01 mg EGA) demonstrated a greater hepatoprotective effect. Thus, according to liver histological analysis, the aqueous and methanolic leaf extracts of A. cordifolia could attenuate the hepatotoxicity induced by antituberculosis drugs in rats.

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“…Several reports on the biological activities of A. cordifolia have shown the plant to possess antiinflammatory, antidiarrhoeal, hepaprotective, antiviral, and antidiabetic properties [ 5 , 6 , 7 , 8 , 9 ]. In addition, various antimicrobial screenings of A. cordifolia have revealed its effectiveness against a wide range of pathogenic microbes including gastrointestinal, skin, respiratory, and urinary tract pathogens, thus supporting the traditional use of the plant for the treatment of such ailments [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking

Sinan

Etienne

et al. 2021

Biomolecules

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Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. is a well-known African medicinal plant traditionally used for various healing purposes. In the present study, methanolic, ethyl acetate and infusion extracts of A. cordifolia leaves were studied for their total phenolic and flavonoid contents and screened for their chemical composition. Moreover, the enzyme (acetyl- and butyryl-cholinesterases, α-amylase, α-glucosidase, and tyrosinase) inhibitory and cytotoxicity activities on HepG2: human hepatocellular carcinoma cells, B16 4A5: murine melanoma cells, and S17: murine bone marrow (normal) cells of extracts were evaluated. Finally, components-targets and docking analyzes were conducted with the aim to unravel the putative mechanisms underlying the observed bio-pharmacological effects. Interestingly, the infusion and methanolic extracts showed significantly higher total phenolic and flavonoid contents compared with the ethyl acetate extract (TPC: 120.38–213.12 mg GAE/g and TFC: 9.66–57.18 mg RE/g). Besides, the methanolic extracts followed by the infusion extracts were revealed to contain a higher number of compounds (84 and 74 compounds, respectively), while only 64 compounds were observed for the ethyl acetate extract. Gallic acid, ellagic acid, shikimic acid, rutin, quercetin, myricetin, vitexin, quercitrin, kaempferol, and naringenin were among the compounds that were commonly identified in all the studied extracts. Additionally, the methanolic and infusion extracts displayed higher antioxidant capacity than ethyl acetate extract in all assays performed. In ABTS and DPPH radical scavenging assays, the methanol extract (500.38 mg TE/g for DPPH and 900.64 mg TE/g for ABTS) exhibited the best ability, followed by the water and ethyl acetate extracts. Furthermore, the extracts exhibited differential enzyme inhibitory profiles. In particular, the methanolic and infusion extracts showed better cytotoxic selectivity activity against human hepatocellular carcinoma cells. Overall, this study demonstrated A cordifolia to be a species worthy of further investigations, given its richness in bioactive phytochemicals and wide potentialities for antioxidants and pharmacological agents.

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Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Cited by 6 publications

References 12 publications

Protective effect of Alchornea cordifilia leaf extract on carbon tetrachloride-induced liver damage in Wistar rats

Protective effect of Alchornea cordifilia leaf extract on carbon tetrachloride-induced liver damage in Wistar rats

Effect of Alcornea cordifolia Aqueous and Methanolic Leaf Extracts against Antituberculosis Drugs Induced Liver Damage in Rats

Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking

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