Protective effect of Alchornea cordifilia leaf extract on carbon tetrachloride-induced liver damage in Wistar rats

Abstract

The effect of aqueous extract of the leaves of Alchornea cordifolia on Carbon tetrachloride (CCl4)-induced liver damage was investigated in experimental rats. Treatment of separate groups of rats with 100mg/kg, 150mg/kg and 200mg/kg aqueous leaf extracts of Alchornea cordifolia for 2 weeks after establishment of CCl4 induced liver damage, resulted in significantly (P<0.05) less hepatotoxicity when compared to the CCl4-induced group, as measured by serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. The effect of extract was statistically significant (P<0.05) and was dose dependent. Histopathological study also showed significant reduction and even reversal of liver damage in the rats. The results of this study show that aqueous leaf extract of Alchornea cordifolia has a potent anti-hepatotoxic action against CCl4 induced liver damage in rats.

Modulation of cadmium induced haematological and renal damages by ethanol leaf extract of Pterocarpus mildbraedii in male Wistar rats

“…The cadmium induced alterations in some histological features of the kidney tissue observed in this study are in agreement with the report of other authors (Dkil et al, 2020;Ilesanmi and Adeogun, 2022). Expectedly, ethanol leaf extract of Pterocarpus mildbraedii restored normal histological architecture to the kidneys as earlier observed by Urom and Usin (2023). In reference to the fact that cadmium induced renal damage proceeds by the free radical mechanism, it is considered safe to attribute the ameliorative impact of the extract to its antioxidant potentials as previously reported (Akpanyung et al, 2022).…”

“…Cadmium induced renal toxicity has also been documented (Saturag, 2018). These are in contradistinction, to the haematological (Omololu et al, 2023) and nephroprotective (Urom and Usin, 2023) properties of Pterocarpus mildbraedii leaves. These observations provided impetus for the current investigation.…”

“…There are indications that cadmium induced renotoxicity is mediated by free radicals (Genchi et al, 2020;Mafulul et al, 2020;Yan and Allen, 2021). Hence, the ability of ethanol leaf extract of Pterocarpus mildbraedii to normalize the raised concentrations of urea and creatinine could be attributed to its antioxidant properties as earlier postulated (Usunomena and Chinwe, 2016;Fajobi et al, 2020;Urom and Usin, 2023). The kidneys also play a crucial role in regulating serum electrolyte balance (Ajani et al, 2011).…”

“…Alkaloids, flavonoids and tannins have been identified in these leaves (Uchegbu et al, 2015;Usunomena and Chinwe, 2016). The leaf extract of Pterocarpus mildbraedii has also been demonstrated to exhibit antioxidant (Usunomena and Chinwe, 2016), renoprotective (Urom and Usin, 2023) and haematoprotective properties (Victor and Nnonyelum, 2017). Pterocarpus mildbraedii has also been reported to ameliorate cadmium induced hepatotoxicity, oxidative stress and dyslipidaemia in albino rats (Akpanyung et al, 2022).…”

Protective effects of ethanol-water leaf extract of Jatropha gossypiifolia on mouse virus-induced hepatitis (MHV) in male Swiss mice (Mus musculus)

“…When the liver is damaged, these enzymes enter the bloodstream in proportion to the degree of damage [24]. There was also a significant (p < 0.01) increase in direct bilirubinemia.…”