Hepatoprotective and Antioxidant Activity of &lt;i&gt;Lannea coromandelica&lt;/i&gt; Linn. on Thioacetamide Induced Hepatotoxicity in Rats

Rao, V. Srinivasa; Einstein, J. Wilkin; Das, Krishna Kaveri

doi:10.18052/www.scipress.com/ilns.8.30

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Such finding was in consistence with Alshawsh et al (2011) and Al-Attar (2012), in mice treated with TAA. Also, the liver sections showed disarrangement, degeneration of normal hepatic cells, vacuolar degeneration, necrosis, and inflammatory cell infiltration with intense centrilobular necrosis and congestion and destruction of central vein that was similar to finding of Salama et al (2012) and Rao et al (2014).…”

Section: Discussionsupporting

confidence: 72%

Biochemical and histopathological effect of probiotics on experimentallyinduced liver fibrosis in rat

Elhamid

et al. 2016

Benha Veterinary Medical Journal

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The objective of the present study was to evaluate the biochemical effect of probiotics treatment on Thioacetamide (TAA) induced liver fibrosis in rats. Thirty white male Sprague Dewily rats of 8-10 weeks old and Weighing 150 to 200 g were used in the experiment. Rats were randomly divided in to 2 main groups, 1st group acts as normal control, 2nd group was injected with TAA intraperitoneally (200mg/kg b.wt) twice a week for 6 weeks for the induction of liver fibrosis, after that the 2 nd group was subdivided into 2 subgroups1 st subgroup received no drugs and served as positive control, 2 nd subgroup was treated with a daily dose of probiotics (0.0128×10 9 bacteria per gram of rat body weight) which is equivalent to (135mg/kgb.wt) orally for 6 weeks. Blood samples were collected twice after 3 and 6 weeks of probiotics treatment for biochemical examination, then rats were decapitated and liver specimens were collected for histopathological examination. Intraperitoneal supplementation of TAA caused increase in serum level of AST, ALT, Tbil, Dbil and pro-inflammatory cytokines as TNFα and IL6, decrease in serum level of Albumin and total protein. Furthermore, histopathological examination revealed extensive degeneration, inflammatory infiltration and nodulation of the liver. Probiotics treatment revealed decrease in serum level of ALT, AST, Tbil, Dbil and pro-inflammatory cytokines as TNFα and IL6, decrease in serum level of Albumin and Total protein. Moreover, histopathological examination revealed mild inflammation and less nodulation of the hepatic parenchyma.

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Section: Discussionsupporting

confidence: 72%

Biochemical and histopathological effect of probiotics on experimentallyinduced liver fibrosis in rat

Elhamid

et al. 2016

Benha Veterinary Medical Journal

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“…A fast increase in AST, ALP and ALT activity in paracetamol-treated rabbit serum may be caused by increased plasma membrane permeability or cellular necrosis that results in enzyme leakage into the bloodstream (23). These biochemical markers AST, ALP and ALT are utilized to diagnose early liver injury (24). It elevates serum levels of AST, ALP and ALT, and total bilirubin when the liver cell membrane is destroyed, which can happen in a number of common illnesses (25,26).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antioxidant activity of Zingiber officinale alcoholic extract and vitamin e on liver damage induced by paracetamol drug in males of New Zealand rabbits

Hadree¹,

Farhan²,

Fadhil³

2022

IJVS

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The aim of study is to reduce hepatic damage from paracetamol will be funded using alcohol extract for ginger and vitamin E as antioxidants in male New Zealand rabbits. Paracetamol (acetaminophen) is a widely used over-the-counter analgesic and antipyretic drug which is known to cause liver injuries in both humans and experimental animals when administered in overdose. The current study was conducted at the animal house of the College of Veterinary Medicine, Tikrit University to detect certain side effects developed with the use of the drug paracetamol, some physiological values resulting from liver damage through the use of 40 male New Zealand rabbits aged 5-7 months, randomly divided into four equal groups, including: The control group were given the normal physiological solution and the second group were given the paracetamol drug was given orally 400 mg/kg per rabbit while the third group was given vitamin e 50 mg/kg body weight as well as 400 mg/kg of the paracetamol drug was given orally. The fourth group was dosed with ginger alcoholic extract of 150 mg/kg body weight, which was given 400 mg/kg of the paracetamol drug was given orally. The study's findings demonstrated a significant decrease in the levels of catalase (CAT), super oxidase dismutase (SOD) and glutathione (GSH) in the treatment with a paracetamol drug compared to the control group, as well as a significant increase in the levels of liver enzymes and malondialdehyde. The study's results also found a significant decline in the levels of liver enzymes and malondialdehyde while revealing a significant increase in the levels of CAT, SOD and GSH in 3 rd and 4 th group compared to 2 nd group. From the aforementioned findings, it can be concluded that vitamin e and ginger alcohol extract both reduce the unfavorable and harmful effects in some physiological parameters coming from liver damage caused by Paracetamol drug usage.

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“…protective activity might be due its effect against cellular leakage and loss of functional integrity of cell membrane in hepatocytes. The increase in the activities of AST and ALT in serum of rats treated by paracetamol might be due to increased permeability of plasma membrane or cellular necrosis leading to leakage of the enzymes to the blood stream (Rao and Das, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…It can work when a large portion of it is removed or diseased. It participates in variety of metabolic activities and thus may exposed to many toxicants, chemical and drugs which could injure it (Rao and Das, 2014). It is the body metabolic clearing house as its smooth endoplasmic reticulum is capable for dealing with both endogenous chemicals like cholesterol, fatty acids, hormones specially steroids and proteins, as well as exogenous ones as alcohol and drugs.…”

Section: Introductionmentioning

confidence: 99%

Protective impacts of Cupressus sempervirens leaves extracts against paracetamol hepatotoxicity

Salman

El-Aleem

Rahman

et al. 2017

Benha Veterinary Medical Journal

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The main objective of this study is to evaluate the antioxidant activity of Cupressus sempervirens leaves extract invitro and rat model in which paracetamol was used to induce hepatic damage. The antioxidant and anti-quorum sensing activities of eight extracts were studied. Total phenolic compounds and scavenging radical effect on 2, 2diphenylpicrylhydrazyl (DPPH) were investigated, (the specific phenolic and flavonoid composition quantification for hydrolyzed ethyl acetate fraction pH 4 were performed by HPLC E-vanilic, Alpha-coumaric, Salicylic and Ferulic were found as the major phenols. Narengin, Hisperidin, Quercetrin and Hispertin were found as the major flavonoids. Biological experiment was carried out for thirty days. Results revealed that a significant increase in serum ALT, AST, ALP, Total bilirubin, TG, Total cholesterol, (LDLC) and nitric oxide in rats treated with paracetamol. However administration of Cupressus sempervirens in paracetamol induced liver toxicity in rats exhibited a significant decrease in all mentioned parameters on the other hand a significant decrease in serum total protein albumin concentration, (HDLC), Catalase, glutathione peroxidase (GPX), Glutathione-S-transferase (GST) and Glutathione reduced were observed in paracetamol induced hepatic toxicity in rats when compared with control normal group. Meanwhile Cupressus sempervirens leaves resulted in significant in all mentioned parameter and when enhanced the activity of antioxidant enzymes in liver tissue. It could be concluded that, inhibition of peroxidation, inflammation and oxidative stress and enhanced antioxidant status in rat liver tissue by Cupressus sempervirens suggest the potential efficacy of Cupressus sempervirens as an addition Hepatoprotective, anti-inflammatory and anti-hepatotoxic agent in treatment of liver toxicity

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Hepatoprotective and Antioxidant Activity of <i>Lannea coromandelica</i> Linn. on Thioacetamide Induced Hepatotoxicity in Rats

Cited by 10 publications

References 13 publications

Biochemical and histopathological effect of probiotics on experimentallyinduced liver fibrosis in rat

Biochemical and histopathological effect of probiotics on experimentallyinduced liver fibrosis in rat

Evaluation of the antioxidant activity of Zingiber officinale alcoholic extract and vitamin e on liver damage induced by paracetamol drug in males of New Zealand rabbits

Protective impacts of Cupressus sempervirens leaves extracts against paracetamol hepatotoxicity

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