Hepatoprotective and antioxidant activity of Lannea coromandelica bark extract (LCBE) was investigated on thioacetamide induced hepatotoxicity in rats. Hepatotoxicity was induced by thioacetamide (TAA) administration (100 mg/kg. s.c). LCBE at different doses (400 and 200 mg/kg) were administered orally to male wistar rats. Thioacetamide caused elevation of serum concentration of AST, ALT, ALP, serum bilirubin and also reduced serum concentration of total protein, albumin, sodium, potassium in animals as compared to control (p < 0.05) but LCBE treated rats showed maximum reduction of AST [(138±5.1) IU/L], ALT [(71 ±2.7) IU/L], ALP [(140 ±1.9) IU/L] with the high dose (400 mg/kg bw) of combined aqueous and alcoholic bark extract. Whereas, serum bilurubin, cholesterol, sugar and LDH content were varied with the treatments but showed higher with the only ethanolic extract at dose of 400 mg/kg. The IC 50 value was observed as (83.28 ±2.12) µg/mL, for DPPH radical scavenging activity. Result concluded that ethanolic extract and combined aqueous and alcoholic bark extract of L. coromandelica showed a potential hepatoprotective and antioxidant activities might be due to the presence of phenolic groups, terpenoids and alkaloids.

Hepatoprotective and antioxidant activity of Lannea coromandelica bark extract (LCBE) was investigated on thioacetamide induced hepatotoxicity in rats. Hepatotoxicity was induced by thioacetamide (TAA) administration (100 mg/kg. s.c). LCBE at different doses (400 and 200 mg/kg) were administered orally to male wistar rats. Thioacetamide caused elevation of serum concentration of AST, ALT, ALP, serum bilirubin and also reduced serum concentration of total protein, albumin, sodium, potassium in animals as compared to control (p < 0.05) but LCBE treated rats showed maximum reduction of AST [(138±5.1) IU/L], ALT [(71 ±2.7) IU/L], ALP [(140 ±1.9) IU/L] with the high dose (400 mg/kg bw) of combined aqueous and alcoholic bark extract. Whereas, serum bilurubin, cholesterol, sugar and LDH content were varied with the treatments but showed higher with the only ethanolic extract at dose of 400 mg/kg. The IC50 value was observed as (83.28 ±2.12) µg/mL, for DPPH radical scavenging activity. Result concluded that ethanolic extract and combined aqueous and alcoholic bark extract of L. coromandelica showed a potential hepatoprotective and antioxidant activities might be due to the presence of phenolic groups, terpenoids and alkaloids.

No abstract

A field experiment was conducted for two consecutive years 2020-2021 and 2021-2022 on clay loam soil at Agricultural College Farm, Bapatla to study the direct and residual effect of integrated use of organics and inorganics on soil nutrient status under rice-sorghum cropping system. The results revealed that at all the growth stages of rice, the highest available nitrogen, phosphorus and potassium were recorded with the application of 100% RDF + 25% N through GLM (T8) and this was on par with T9 (100% RDF + 12.5% N through FYM + 12.5% N through GLM), T3 (125% RDF through inorganic fertilizers) and T7 (100% RDF + 25% N through FYM, whereas the highest available sulphur was recorded in  100% RDF + 25% N through GLM (T8) and it was on par with T9 (100% RDF + 12.5% N through FYM + 12.5% N through GLM) and T7 (100% RDF + 25% N through FYM during 2020 and 2021.  In succeeding sorghum, significantly highest soil available N, P2O5, K2O and sulphur were recorded in T9 (100% RDF + 12.5% N through FYM + 12.5% N through GLM) and it was on par with T8 (100% RDF + 25% N through GLM) and T7 (100% RDF + 25% N through FYM) during both the years of study. Irrespective of the treatments applied to rice crop, the sub plot that received 100% RDF (S3) in rabi recorded significantly highest soil available nutrients at all stages of crop which was on par with 75% RDF (S2) except available sulphur whereas increased NPK levels from 75% RDF (S2) to 100% RDF(S3) did not show any significant difference and lowest was recorded in control (S1) during both the years of study, respectively.