Hepatitis C Virus Genotype Distribution in Patients With Chronic Hepatitis C in Gaziantep Province

Harman, Rezan; Özgür, Günal; Özger, Selçuk

doi:10.5152/kd.2017.17

Cited by 3 publications

(3 citation statements)

References 3 publications

(3 reference statements)

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“…Genotype 3a is observed among intravenous drug users in northern Europe, while 4a is mainly observed in the Middle East and genotype 1b, 2a and 2b infections are observed in elderly populations in Europe and Asia and linked to blood transfusions [12]. Harman et al in a study of 160 patients identified the mean age as 56 years and reported 25% of patients were in the 18-50 year group while 75% were above the age of 50 [10]. In our study, the mean age was identified as 65 years and 88.3% of patients were in the over 50 age group.…”

Section: Discussionmentioning

confidence: 99%

“…There are seven genotypes and 67 subtypes identified for HCV [5]. In Turkey, genotype 1b is observed most commonly, with treatment response at lower levels for genotype 1b compared to other genotypes [6][7][8][9][10][11]. It is important to increase the number of studies on genotype distributions from different centers and regions of the country in terms of identifying the HCV genotype distribution in the whole country in general and creating appropriate treatment algorithms.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C virus genotype distribution in Ordu province

Calgin¹

2019

Ann Clin Anal Med

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Aim: It is important to increase the number of studies on genotype distributions from different centers and regions of the country in terms of identifying the HCV genotype distribution in the whole country in general and creating appropriate treatment algorithms. Our study aimed to identify the HCV genotype distribution in patients infected with HCV attending our hospital in Ordu Province in the Central Black Sea region. Material and Method: The study included a total of 196 patients whose samples were sent to our laboratory for HCV viral load measurements from January 2016 to May 2018 with HCV-RNA positivity identified. Genotype definition was completed with the real-time PCR method. Results: It was observed that 4 patients (2%) had genotype 1, 7 patients (3.6%) had genotype 1a, 179 patients (91.4%) had genotype 1b, 5 patients (2.5%) had genotype 3 and 1 patient (0.5%) had genotype 4. Discussion: The most common genotype observed among patients attending our hospital was genotype 1. Genotypes 3 and 4 were rarely observed in comparison to Turkish data, similar to other provinces in regions receiving little migration. As medication resistance and treatment failure is high for genotype 1, the risk of encountering treatment failure continues to be a serious problem in our region.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus genotype distribution in Ordu province

Calgin¹

2019

Ann Clin Anal Med

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“…This alteration may be due to immigrants, touristic activities and different risk factors for HCV infection, as well as increased safety procedures in medical practice. Table 4 shows the results of some of the HCV genotyping studies in Turkey (13,14,15,16,17,18,19,20,21,22,23,24,25,26,27).…”

Section: Discussionmentioning

confidence: 99%

Distribution of Hepatitis C Virus Genotypes in Aydın Province

Tiryaki¹,

Duran²,

Özçolpan³

2018

vhd

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Objectives: In this study, we evaulated the distribution and alteration of hepatitis C virus (HCV) genotypes throughout years which has a clinical importance in the treatment and follow-up. Materials and Methods: Test results obtained from blood samples sent to the molecular microbiology laboratory at Aydın State Hospital for HCV genotype determination were analyzed retrospectively. A total of 182 samples collected between 2014 and 2018 were enrolled in the study. The determination of genotype and viral load of the samples were performed by real time polymerase chain reaction. Results: 53.8% (98/182) of the samples were collected from male patients and 46.2% (84/182) from female patients. The mean age of the patients was 58.5±15.5 years. 69.2% of the samples were genotype 1b, 18.1%-genotype 1a, 2.2%-genotype 1 (those different from subtype 1a and 1b), 1.7%-genotype 2, 7.2%genotype 3, and 1.7% of the samples were genotype 4. Conclusion: In the present study, genotype 1 was the most common genotype (89.5%). Additionally, we have observed a decrease in the frequency of genotype 1b and a slightly increase in the frequency of other genotypes. Determination of HCV genotypes is important for treatment and prognosis of HCV infections.

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