2010
DOI: 10.1590/s0102-86502010000200011
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Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy

Abstract: PURPOSE: To evaluate hemodynamics and bispectral index (BIS) in bitches anesthetized with ketamine and midazolam in combination with dexmedetomidine or medetomidine and submitted to ovariohysterectomy. METHODS: Twenty bitches pretreated with levomedetomidine and buprenorphine were anesthetized with 5 mg.kg-1 ketamine and 0.2 mg.kg-1 midazolam i.v. Continuous infusion of 0.4 mg.kg-1.h-1 midazolam and 20 mg.kg-1.h-1 ketamine was initiated in combination with DEX (n=10): 20 µg.kg-1.h-1 dexmedetomidine or MED (n=1… Show more

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Cited by 5 publications
(18 citation statements)
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References 16 publications
(23 reference statements)
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“…However, our CRI doses (0.5 and 1 μg kg −1 hour −1 for groups D1 and D2, respectively) were lower than those reported by Silva Fdo et al. () (20 μg kg −1 hour −1 ), who reported a considerable and continuous decrease of the BIS and EMG in dogs subjected to ovariohysterectomy and anaesthetized with midazolam and ketamine. van Oostrom et al.…”
Section: Discussioncontrasting
confidence: 76%
See 1 more Smart Citation
“…However, our CRI doses (0.5 and 1 μg kg −1 hour −1 for groups D1 and D2, respectively) were lower than those reported by Silva Fdo et al. () (20 μg kg −1 hour −1 ), who reported a considerable and continuous decrease of the BIS and EMG in dogs subjected to ovariohysterectomy and anaesthetized with midazolam and ketamine. van Oostrom et al.…”
Section: Discussioncontrasting
confidence: 76%
“…Silva Fdo et al. () reported a considerable decrease in EMG activity in dogs after the administration of medetomidine or dexmedetomidine. There were similar findings in our study in the D2 group, where the values were significantly lower than in groups D0 and D1.…”
Section: Discussionmentioning
confidence: 99%
“…It is used for sedation or as an adjuvant in anesthesia. Only the S-enantiomer dexmedetomidine is pharmacologically active [1][2][3][4]13]. Both enantiomers are able to inhibit cytochrome P450 (CYP) enzymes whereas levomedetomidine is the stronger inhibitor [1,3,4].…”
Section: Introductionmentioning
confidence: 99%
“…All α 2 -agonists decrease the rate of respiration, which does not cause an increase in the partial pressure of carbon dioxide (PaCO 2 ) in arterial blood (Lee 2011;Lamont et al 2012;Lee et al 2015;Restitutti et al 2017) but may reduce the respiratory response to hypercapnia (Cardoso et al 2014). Furthermore, α 2 -agonists contribute to an insignificant decrease in body temperature (Sinclair 2003;Carter et al 2010;Silva et al 2010).…”
mentioning
confidence: 99%
“…administration of medetomidine results in more pronounced cardiovascular effects than those that manifest following administration through the intramuscular (i.m.) route (Silva et al 2010).…”
mentioning
confidence: 99%