2016
DOI: 10.1016/j.chroma.2016.07.060
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Pharmacokinetics of ketamine and three metabolites in Beagle dogs under sevoflurane vs. medetomidine comedication assessed by enantioselective capillary electrophoresis

Abstract: Ketamine is often used for anesthesia in veterinary medicine. One possible comedication is the sedative α-agonist medetomidine. Advantages of that combination are the compensation of side effects of the two drugs and the anesthetic-sparing effect of medetomidine. In vitro studies showed that medetomidine has an inhibitive effect on the formation of norketamine. Norketamine is the first metabolite of ketamine and is also active. It is followed by others like 6-hydroxynorketamine and 5,6-dehydronorketamine (DHNK… Show more

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Cited by 22 publications
(31 citation statements)
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“…Thus, an injection time of 10 s with 7 kV was chosen for the final method. Finally, injections from liquid/liquid extracts prepared with a mixture of dichloromethane and ethylacetate (75:25%, v/v; ) or dichloromethane alone were compared. Although best analyte recovery was obtained with the solvent mixture, extraction with dichloromethane provided better peak shapes with electrokinetic sample injection .…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…Thus, an injection time of 10 s with 7 kV was chosen for the final method. Finally, injections from liquid/liquid extracts prepared with a mixture of dichloromethane and ethylacetate (75:25%, v/v; ) or dichloromethane alone were compared. Although best analyte recovery was obtained with the solvent mixture, extraction with dichloromethane provided better peak shapes with electrokinetic sample injection .…”
Section: Resultsmentioning
confidence: 99%
“… and kept at –80°C until used for the in vitro incubation work. Animal plasma samples stemmed from two previously conducted ketamine studies which were executed with the permission of the respective Committee for Animal Experimentation . In the first trail, ponies received an i.v.…”
Section: Methodsmentioning
confidence: 99%
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“…Microsoft Excel (Microsoft, Redmont, WA, USA) and SigmaPlot software version 12.5 (Systat Software, San Jose, CA, USA) were used for data evaluation and presentation, respectively. Pharmacokinetic modeling of methadone enantiomers was performed with the Phoenix WinNonlin 6.4 software (Certara: Implementing Translational Science, Cary, NC, USA) as described previously for ketamine and metabolites in plasma of Beagle dogs .…”
Section: Methodsmentioning
confidence: 99%