A critical point in chiral chromatography–mass spectrometry analysis of ketamine metabolites

Abstract

Ketamine is a widely used dissociative drug, whose quantification in plasma and urine can be of pharmacological, toxicological, and clinical interest. Although tandem mass spectrometry allows the reliable determination of ketamine and its metabolites in biological matrices, the structural similarity between norketamine (main active metabolite) and dehydronorketamine (a less relevant metabolite) can represent a

Synthesis, characterization, method development, and validation of nor‐ethylmorphine hydrochloride reference material using established analytical techniques for dope control analysis

“…The mixture was compressed using a hydraulic press and converted to KBr thin transparent pellet. This pellet was scanned for the IR region using an FT‐IR spectrophotometer (Model‐ALPHA II, make: Bruker) and functional groups of nor‐ethylmorphine HCl was determined 13–18 …”