Hematological and parasitological changes in mice experimentally infected by Trypanosoma cruzi and treated with biotherapy 7dH

Ferraz, Fabiana Nabarro; Bilotti, Carolina Correia; Aleixo, Denise Lessa; Herrero, J. C. M.; Nascimento, Anélio Dias; Araújo, Silvana Márques de

doi:10.1016/j.eujim.2014.07.017

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…In fact, contradictory and non-linear effects may be observed in complex systems that involve the fine modu-lation of biological functions, mainly after the use of highly diluted medications. 9,11 According to some authors, the use of highly diluted medications in the acute phase of infection requires a higher stimulus frequency. 10,29 However, overstimulation with biotherapy 7dH that was given 3 days before infection and every day after infection may be directly related to an increase in parasitemia in most of the animals.…”

Section: Discussionmentioning

confidence: 99%

“…Sandri et al 12 reported a decrease in serum transforming growth factor b (TGF-b) concentrations, an increase in the number of apoptotic cells, and a decrease in hepatic inflammation in animals that were treated with biotherapy 17dH after infection. In addition to immunomodulatory action, Ferraz et al 11 reported that pretreatment with T. cruzi biotherapy 7dH altered the dynamics of blood cells in mice that were experimentally infected with T. cruzi.…”

Section: Discussionmentioning

confidence: 99%

“…The animals were clinically evaluated 3 days before infection and on days 0, 4,8,11,15,18,21,25, and 28 after infection using a standard schedule. Body mass (g) was measured using a semi-analytical balance (BEL Engineering, Class Mark II).…”

Section: Clinical Parametersmentioning

confidence: 99%

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Different treatment schemes and dynamizations of Trypanosoma cruzi biotherapies: what information do they transfer to the organism in infected mice?

et al. 2016

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The effects of T. cruzi biotherapies depend on frequency at which they are administered, dynamization, and host-parasite relationship/individual susceptibility of treated organism. Biotherapy appeared to transfer to infected organism 'antigenic information' related to parasite and 'disease information' related to molecules produced by host's immune response and contained in the buffy coat used to prepare the medication.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Different treatment schemes and dynamizations of Trypanosoma cruzi biotherapies: what information do they transfer to the organism in infected mice?

et al. 2016

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“…Previous studies have investigated the prophylactic and therapeutic effects of biotherapies in acute murine infection by this protozoan. These studies reported mainly parasitological, clinical, histopathological and hematological effects (Aleixo et al, 2012;Almeida et al, 2008;Ferraz et al, 2011Ferraz et al, , 2014aQueiroz et al, 2006;Sandri et al, 2015). However, only a few studies have directly investigated the immunomodulatory effects of biotherapies against T. cruzi infection (Almeida et al, 2008;Ferraz et al, 2014b;Queiroz et al, 2006;Sandri et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Modulation of IFN-γ, IL-4 and IL-17 Cytokines is Related to Parasitemia Control in Mice Infected by <i>Trypanosoma cruzi</i> and Treated with Biotherapy

Ferraz¹,

Veiga²,

Aleixo³

et al. 2015

OnLine Journal of Biological Sciences

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The study of biotherapies as an intervention in experimental models of infection is a possible means to understand the effects of these highly diluted medications. The present study evaluated the immunological and parasitological effects of biotherapies that were prepared from mouse serum that was uninfected (sarcode: BSNI 13cH group) and chronically infected with the Y strain of T. cruzi (nosode: BSI 13cH group), dynamization 13cH, in male Swiss mice at 28 days of age. On days 0 and 12 after infection (a.i.), the BSNI 13cH group exhibited a pronounced Th1 response that was attributable to a reduction of interleukin-4 (IL-4) concentrations, with no significant differences in interferon-γ (IFN-γ) concentrations and a decrease in IL-17A concentrations on day 0 a.i. compared with the control and BSI 13cH groups. However, this cytokine balance was not sufficient to alter blood parasitemia in treated animals, likely because of a decrease in IFN-γ concentrations on day 8 a.i., thus hindering a more effective Th1 response. In contrast, the BSI 13cH group presented a pronounced Th2 response that was attributable to an increase in IL-4 concentrations (on days 0 and 8 a.i.) and a decrease in IFN-γ concentration (on day 12 a.i.) compared with the control and BSNI 13cH groups. This cytokine balance suppressed the immune response to T. cruzi in murine infection, resulting in a significant increase in blood parasitemia, decrease in the patent period and subsequently a decrease in survival time. The results indicate that these highly diluted medications differentially modulate the immune system and represent a substantial contribution to the field of homeopathic medicine, providing evidence of the action of these medications.

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“…Biotherapies are highly diluted medications that are prepared in accordance with homoeopathic pharmaco-technical methods. A Brazilian study [10] in this issue determines the therapeutic responsiveness of biotherapy 7dH to Chagas disease using a mouse model. The study reports that the administration of T. cruzi biotherapy 7dH 30 days before infection altered the experimental course of infection by T. cruzi and haematological parameters.…”

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confidence: 99%

The therapeutic value of natural products derived from Chinese medicine—A systems based perspective

Guo

Bauer²,

Robinson³

2014

European Journal of Integrative Medicine

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Hematological and parasitological changes in mice experimentally infected by Trypanosoma cruzi and treated with biotherapy 7dH

Cited by 6 publications

References 25 publications

Different treatment schemes and dynamizations of Trypanosoma cruzi biotherapies: what information do they transfer to the organism in infected mice?

Different treatment schemes and dynamizations of Trypanosoma cruzi biotherapies: what information do they transfer to the organism in infected mice?

Modulation of IFN-γ, IL-4 and IL-17 Cytokines is Related to Parasitemia Control in Mice Infected by <i>Trypanosoma cruzi</i> and Treated with Biotherapy

The therapeutic value of natural products derived from Chinese medicine—A systems based perspective

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Hematological and parasitological changes in mice experimentally infected by Trypanosoma cruzi and treated with biotherapy 7dH

Cited by 6 publications

References 25 publications

Different treatment schemes and dynamizations of Trypanosoma cruzi biotherapies: what information do they transfer to the organism in infected mice?

Different treatment schemes and dynamizations of Trypanosoma cruzi biotherapies: what information do they transfer to the organism in infected mice?

Modulation of IFN-&gamma;, IL-4 and IL-17 Cytokines is Related to Parasitemia Control in Mice Infected by <i>Trypanosoma cruzi</i> and Treated with Biotherapy

The therapeutic value of natural products derived from Chinese medicine—A systems based perspective

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Modulation of IFN-γ, IL-4 and IL-17 Cytokines is Related to Parasitemia Control in Mice Infected by <i>Trypanosoma cruzi</i> and Treated with Biotherapy