The therapeutic value of natural products derived from Chinese medicine—A systems based perspective

Guo, Di; Bauer, Rudolf; Robinson, Nicola

doi:10.1016/j.eujim.2014.09.132

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Moreover, the holistic, personalized approach of these medical systems is difficult to assess by many of the bioassay systems currently used to prove pharmacological activity. However, the emerging omics- and systems biology-based technologies might be better suited to address these issues, due to their more holistic orientation (Guo et al, 2014; Ngo et al, 2013).…”

Section: Approaches For the Discovery Of New Pharmacologically Actmentioning

confidence: 99%

Discovery and resupply of pharmacologically active plant-derived natural products: A review

Atanasov

Waltenberger

Pferschy‐Wenzig

et al. 2015

Biotechnology Advances

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Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source. They are comparably easy to produce and resupply, and demonstrate good compatibility with established high throughput screening (HTS) platforms. However, at the same time there has been a declining trend in the number of new drugs reaching the market, raising renewed scientific interest in drug discovery from natural sources, despite of its known challenges. In this survey, a brief outline of historical development is provided together with a comprehensive overview of used approaches and recent developments relevant to plant-derived natural product drug discovery. Associated challenges and major strengths of natural product-based drug discovery are critically discussed. A snapshot of the advanced plant-derived natural products that are currently in actively recruiting clinical trials is also presented. Importantly, the transition of a natural compound from a “screening hit” through a “drug lead” to a “marketed drug” is associated with increasingly challenging demands for compound amount, which often cannot be met by re-isolation from the respective plant sources. In this regard, existing alternatives for resupply are also discussed, including different biotechnology approaches and total organic synthesis.While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs also in the future.

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Section: Approaches For the Discovery Of New Pharmacologically Actmentioning

confidence: 99%

Discovery and resupply of pharmacologically active plant-derived natural products: A review

Atanasov

Waltenberger

Pferschy‐Wenzig

et al. 2015

Biotechnology Advances

Self Cite

2,189

1,385

View full text Add to dashboard Cite

show abstract

“…The "holistic view" and "preventive treatment of disease" of TCM, along with the synergistic effect of herbal treatment, showed unique advantages in the prevention and treatment of some chronic complex diseases, such as diabetes [8,9]. Donglingcao is derived from the dry aerial part of Isodon rubescens (Hemsl.)…”

mentioning

confidence: 99%

Network Pharmacological Screening of the Active Ingredients and Hypoglycemic Effect of Isodon rubescens in the Treatment of Diabetes

Xue

Wang

et al. 2020

Planta Med

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This study was firstly to study the relationship of “ingredient-target-pathway” and the pharmacological effects of Isodon rubescens for the treatment of diabetes. Based on a network pharmacology method, 138 active ingredients of Isodon rubescens were screened from the relative literatures, and their targets were confirmed by comparing these with the hypoglycemic targets in the DrugBank database. Results showed that Isodon rubescens contained 25 hypoglycemic ingredients, such as rabdoternin A, rabdoternin B, and epinodosinol. These ingredients could activate 6 hypoglycemic targets, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), integrin α-L (ITGAL), integrin β-2 (ITGB2), progesterone receptor (PGR), glucocorticoid receptor (NR3C1), and nuclear receptor subfamily 1 group I member 2 (NR1I2). These targets were involved in 94 signaling pathways, such as the Rap1, PI3K-Akt, and HIF-1 signaling pathways. The cell viability showed that the human umbilical vein endothelial cells (HUVECs) treated with alcohol extract (1.00 g/L) and the water extract (0.13 – 0.50 g/L) exhibited high viability compared to the model group (p < 0.05), respectively. 0In animal experiments, the rats treated with water extract of Isodon rubescens showed significant hypoglycemic effects compared to rats in the model group (p < 0.05). Overall, this approach provides an efficient strategy to explore hypoglycemic ingredients of Isodon rubescens and other traditional Chinese medicine.

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Applications for Treatment of Neurodegenerative Diseases

Ježek

Hlaváček

Šebestı́k

2017

Progress in Drug Research

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The therapeutic value of natural products derived from Chinese medicine—A systems based perspective

Cited by 4 publications

References 11 publications

Discovery and resupply of pharmacologically active plant-derived natural products: A review

Discovery and resupply of pharmacologically active plant-derived natural products: A review

Network Pharmacological Screening of the Active Ingredients and Hypoglycemic Effect of Isodon rubescens in the Treatment of Diabetes

Applications for Treatment of Neurodegenerative Diseases

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