Applications for Treatment of Neurodegenerative Diseases

Acridine as Bioinspired Corrosion Inhibitors

“…Bromo(methoxy)methane reacts onto the 4 th position and C-5 position of acridine in the highly acidic environment at 20 °C for few hours to yield either 4,5bis(bromomethyl)acridines or 4-(bromomethyl) acridines which was further exposed to several amendments. [20,21] C-9 position of acridines is very much susceptible to the nucleophilic addition to yield acridanes, which often are rearomatized. Nitrogen atom present at the C-10 position of the acridine ring is also very prone to the nucleophilic addition reaction and can be modified to the alkyl derivatives.…”

“…Bromo(methoxy)methane reacts onto the 4 th position and C‐5 position of acridine in the highly acidic environment at 20 °C for few hours to yield either 4,5‐bis(bromomethyl)acridines or 4‐(bromomethyl) acridines which was further exposed to several amendments. [ 20,21 ]…”

Raman Spectroscopy with Nanoparticles for Investigation of Protein Tyrosine Oxidation

“…Reactive oxygen and nitrogen species play important physiological and pathological roles [1,2]. They are signaling molecules and are used by the immune system as a defense against pathogens [3,4].…”

“…If they appear in high concentrations and cannot be quenched by antioxidants, oxidative stress occurs [5,6]. Oxidative stress is implicated, for example, in Diabetes mellitus type 2, or in many neurodegenerative diseases [2,5,6].…”

Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

“…The multifunctional properties of tacrine derivatives, which have been discovered in recent years continue to stimulate significant interest in this field of chemistry (Anand & Singh, 2013;Čolović, Krstić, Lazarević-Pašti, Bondžić, & Vasić, 2013;Hamulakova et al, 2016;Hamulakova, Janovec, Soukup, Jun, & Kuca, 2017;Kozurkova & Kristian, 2014;Martorana et al, 2016;Melo et al, 2012;Milelli, Simone, & Ticchi, 2017;Panek, Wichur, Godyń, Pasieka, & Malawska, 2017;Proctor & Harvey, 2000;Thiratmatrakul et al, 2014;Tumiatti et al, 2010;Viayna, Sabate, & Muñoz-Torrero, 2013;Wu et al, 2017). In addition to their two basic trades concerning the inhibition of AChE/butyryl cholinesterase (AChE/BChE) and Aβ aggregation, tacrine congeners are also characterized by a variety of other features such as the ability to protect against oxidative stress, β-secretase and M 1 muscarinic receptors (Da Costa et al, 2013;Ježek, Hlaváček, & Šebestík, 2017;Kožurková et al, 2011;Lopes et al, 2017;McHardy, Wang, McCowen, & Valdez, 2017;Soukup et al, 2013;Szymański et al, 2013). Extensive overviews concerning the mode of action of these esterase systems have been the topic of several articles (Boulebd et al, 2017;Guzior, Wieckowska, Panek, & Malawska, 2015;Parveen & Kumar, 2005).…”