Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma

Escobar, Carolina; Grindem, Carol B.; Neel, Jennifer A.; Suter, S. E.

doi:10.1177/0300985811410721

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…Studies performed in the last years on hematopoietic stem cells from canine bone marrow. (Osgood et al 1939, Thomas et al 1962, Epstein et al 1967, Escobar et al 2012, Killian et al 2013, Sato et al 2013, Mathes et al 2014, Vrecenak et al 2014, Rosinski et al 2015, Suter et al 2015, Luangphakdy et al 2016, Lange et al 2017 Fig.2. Studies performed in the last years on mesenchymal stem cells from canine bone marrow.…”

Section: Topic Of General Interestmentioning

confidence: 99%

Bone marrow stem cell applied in the canine veterinary clinics

Gomes

Oliveira²,

Pinheiro

et al. 2017

Pesq. Vet. Bras.

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Cell therapy represents an old therapeutic practice initiated with the transfusion of whole blood in different clinical situations. There is now a breakthrough in the study of multipotent stem cell therapy because of its functionality in regeneration of tissues, which promotes attention of the scientific community. Bone marrow is one of the main sources of multipotent stem cells, composed by hematopoietic stem cells responsible for the renewal of the cellular components of the blood, and mesenchymal stem cells that aid in the regeneration of tissues. These cells have a strong potential for the treatment of several diseases, due their main characteristics such as high plasticity, capacity for self-renewal and immunomodulation. Although, there are many studies that show good results with the use of cell therapy as a form of treatment for several diseases, some studies still show inconclusive or unsatisfactory results. Therefore, the objective of this study was to review the application of bone marrow stem cells in the canine model since improvements on the knowledge of the technique are necessary to enable its applicability with safety and efficacy.

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Section: Topic Of General Interestmentioning

confidence: 99%

Bone marrow stem cell applied in the canine veterinary clinics

Gomes

Oliveira²,

Pinheiro

et al. 2017

Pesq. Vet. Bras.

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“…In more recent years, as veterinary care has become more sophisticated and cell separator machines have become available for clinical veterinary use, both autologous and allogeneic BMT are now options to treat CL. A variety of cell separator machines are able to harvest adequate numbers of canine peripheral blood CD34 + cells for BMT , and dogs with CL will undergo complete hematologic reconstitution after otherwise lethal myeloablative therapy if given an appropriate dose of these cells . Lupu et al .…”

Section: Treatment Of CL and Clinical Trialsmentioning

confidence: 99%

Man's best friend: what can pet dogs teach us about non‐Hodgkin's lymphoma?

Richards

Suter

2014

Immunological Reviews

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Summary Animal models are essential for understanding lymphoma biology and testing new treatments prior to human studies. Spontaneously arising lymphomas in pet dogs represent an underutilized resource that could be used to complement current mouse lymphoma models, which do not adequately represent all aspects of the human disease. Canine lymphoma resembles human lymphoma in many important ways, including characteristic translocations and molecular abnormalities and similar therapeutic responses to chemotherapy, radiation, and newer targeted therapies (e.g. ibrutinib). Given the large number of pet dogs and high incidence of lymphoma, particularly in susceptible breeds, dogs represent a largely untapped resource for advancing the understanding and treatment of human lymphoma. This review highlights similarities in molecular biology, diagnosis, treatment, and outcomes between human and canine lymphoma. It also describes resources that are currently available to study canine lymphoma, advantages to be gained by exploiting the genetic breed structure in dogs, and current and future challenges and opportunities to take full advantage of this resource for lymphoma studies.

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“…Lately, several authors have considered autologous peripheral blood HSPC transplantation in dogs with T or B lymphoma [44,45]. No statistics on the usefulness of such a therapy could be done due to the low number of cases, but succeful engrafment after specifi ed protocols has been demonstrated [45].…”

Section: Peripheral Blood Hematopoetic Stem and Progenitor Cells Are mentioning

confidence: 99%

The Blood is Rich in Different Types of Mesoderm Derived Stem and Progenitor Cells

Filipović

2014

Acta Veterinaria

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The blood and bone marrow have been thoroughly investiagated for more than a century, but we are still gaining surprising new informations. Blood transports different mature cells such as erythrocytes, platelets and granulocytes, but curiously, the blood is also transporting a number of non-differentiated cells of various mesodermal lineages: hematopoietic and mesenchymal stem and progenitor cells, endothelial progenitor cells and very small embryonal like cells are some of the most impressive examples. In adults the bone marrow is the source of practiclly all cells that could be found in the blood. Stem and progenitor cells egress from the bone marrow and home to the bone marrow or various tissues in a highly regulated manner. The fact that the hematopoetic stem and progenitor cells traffi c through the blood and repopulate the bone marrow niche is largely explored in stem cell therapy in human medicine. In this review we will briefl y describe the main characteristics of stem and progenitor cells, the mechanisms of their mobilization from the bone marrow and homing to target tissues. Also, the history and importance of the fact that different stem, progenitor and precursor cells could be isolated from the blood circulation will be discussed in the light of informations concerning their use in human and veterinary medicine.

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Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma

Cited by 20 publications

References 5 publications

Bone marrow stem cell applied in the canine veterinary clinics

Bone marrow stem cell applied in the canine veterinary clinics

Man's best friend: what can pet dogs teach us about non‐Hodgkin's lymphoma?

The Blood is Rich in Different Types of Mesoderm Derived Stem and Progenitor Cells

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