Hemangiopericytoma 11 years later: delayed recurrence of a rare soft tissue sarcoma

Abstract

Hemangiopericytomas (HPCs) are uncommon tumours. We present the case of a 41-year-old female with multiple resections at different sites over the course of 11 years. The approach considerations, as well as treatment options and prognosis are discussed. A 41-year-old female with two previous resections for intracranial meningeal HPC in 2004 and 2008, as well as adjuvant radiotherapy, presented in 2015 with left intrathoracic and left hip recurrence confirmed by positron emission tomography/computed tomography (PET/CT). She underwent left proximal femur resection/reconstruction and video-assisted thoracoscopic surgery (VATS) resection of the intrathoracic tumour was attempted. She was discharged home on her 4th post-operative day with minimal pain. There were no neurosensory or motor deficits. Any patient who has been diagnosed with HPC in the past who develops new symptoms should be worked up for recurrence, regardless of the length of disease-free interval, as our case study suggested. There has yet to be a standardized follow-up regime due to the rarity of these tumours. HPC remains a rare soft tissue sarcoma with high recurrence rate. Planned VATS evaluation and resection is possible provided complete resection with clear surgical margins can be achieved, as clear surgical margins offer the best chance of survival.

Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma

“…Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type [ 1 ]. Although originally presumed to originate from vascular pericytes [ 2 ], the precise histogenesis has not been definitely established.…”

Sinonasal haemangiopericytoma- An unusual swelling in the nasal cavity

“…Hemangiopericytoma arising in the sinonasal cavity tend to have an indolent course and show a characteristic morphology with pericytic proliferation similar to glomus tumor. 7,8 Therefore hemangiopericytoma arising in sinonasal cavity are now termed as sinonasal hemangiopericytoma or glomangiopericytoma and represent a separate entity from soft tissue hemangiopericytoma. 11 Hemangiopericytoma predominantly affects females with peak incidence in the seventh decade of life.It occurs mostly in nasal the cavity as compared to the paranasal sinus.…”

“…4,5 Location of hemangiopericytoma is variable: 15-30% cases are found in the head and neck region; of which sinonasal hemangiopericytoma account for 5.0% of the cases. [6][7][8][9] Females are predominantly affected with peak incidence in the seventh decade of life. 2 In 2005 WHO classification of soft tissue tumours, hemagiopericytoma was identified as a distinct entity and reclassified as borderline and low malignant potential soft tissue tumour of the nose and paranasal sinus.…”

Recurrent Sinonasal Hemangiopericytoma: A Rare Case Report

“…Hemangiopericytoma (HPC) is a rare vascular tumor arising from capillary pericytes [1]- [8]. Hemangiopericytoma (HPC) was first described by Stout and Murray in 1942 [1]- [6]. It affects mainly middle-age adults but can affect all age groups with an equal sex distribution [1]- [7].…”