Vitamin D appears to be of utmost importance in critically ill children.

We describe a 3-month-old male infant who presented with acute onset fever, irritability and marked tachycardia. ECG was suggestive of atrial tachycardia. He developed erythematous blanchable skin rash on day 2 of illness, which progressed to vesiculobullous lesions over a few days' time. The child was managed with intravenous adenosine, carefully monitored fluid boluses, oxygen supplementation and close monitoring. Tachycardia improved within 24 hours. Blood for Chikungunya PCR was positive. The child was discharged after 5 days of hospitalisation with bullous lesions evolving into hyperpigmented macules followed by crusts and hypopigmentation by day 10.

Background: According to WHO watery diarrhea is defined as passage of 3 or more loose stools without blood during preceding 24 hrs. End point of diarrhea was defined as passage of 3 stools of formed consistency. The objective of this study was tocompare the efficacy of two groups of commercially available probiotics in treating children hospitalized with acute non-bloody diarrhea on the basis of duration of stay in hospital, frequency of stool per day and duration of requirement for intravenous fluid. And to compare the results of probiotics in Rotavirus antigen positive children.Methods: A prospective interventional study was conducted in Holy Family Hospital, New Delhi in children aged between 6 months - 5 years hospitalized with acute non bloody diarrhea with 30 children in each group.Results: Total 123 children (6 months - 5 years) admitted in hospital with acute diarrhea, out of which 6 turned out to be bloody, 5 could not be followed up and 3 went LAMA. Finally 109 children with 68 males (62%) with male:female ratio of 1.65. Total 109 children (68 males) were included - Group A (33), 48 in Group B (48) and 28 in Group C (28). In a lateral study, Group A (11), Group B (23) and Group C (10) were Rotavirus positive. 49 children (45%) admitted with stool frequency of 5-10 times per day. Majority of children presented with symptoms like vomiting (68%), fever (55%), decrease oral intake (45%), decrease urine output (25%). Majority of patients 92 children (84%) were between 6 months to 2 years. 44 children (40%) were Rotavirus antigen positive.Conclusions: There is no statistical significant advantage of adding probiotics for treating acute non bloody diarrhea including Rotaviral.

To study the expression of immunomarker CD 44 and evaluate its diagnostic and prognostic significance and its correlation with clinicopathological variables in Breast Carcinoma. Materials and Methods: 50 diagnosed cases of breast carcinoma, presenting clinically with breast lumps were processed routinely for histopathological diagnosis of breast cancer and immunoexpression of CD 44 was performed. The immunoexpression of CD44 was detected mainly at the membrane of tumour cells and the scoring was performed. Results: 217 (98.2%) were females and 4(1.8%) males. Most common subtype involved was invasive carcinoma (NST) in 205(92.8%) cases. Out of 29 cases of grade 2 tumor, 07 (14.0%) showed 1+ score, 10 (20.0 %) showed 2+ score and 12 (24.0%) cases showed 3+ immunoexpression. Out of 25 cases of T2 (2-5 cm) size, 07(14.0%) showed 1+ score, 09(18.0%) case each showed 2+ score and 3+ immunoexpression. Out of 26 cases of stage III, 04(8.0%) showed 1+ score, 09(18.0%) showed 2+ score and 13(26.0%) cases showed 3+ immunoexpression. Out of 05 cases of N3, 02(4.0%) showed 2+ score and 03(6.0%) showed 3+ immunoexpression. Out of 21 cases of basal cell type, 03(6.0%) showed 1+ score, 07(14.0 %) showed 2+ score and 11(22.0%) cases showed 3+ immunoexpression. Out of 11 (50.0%) cases with weak to moderate expression of CD44, 7(31.8%) cases were stable and alive while 4(18.2%) died due to distant metastasis to various sites. Conclusions: CD 44 is associated with disease progression, recurrence, advanced metastasis and reduced disease free survival and can be used in future to predict early diagnosis of advanced disease.

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The authors stated that the written consent was obtained from the patients presented with images in the study. Hasta Onamı: Yazarlar çalışmada görüntüleri ile sunulan hastalardan yazılı onam alındığını ifade etmiştir.

No abstract

Sinonasal hemangiopericytoma, also known as glomangiopericytoma (GPC) is a benign perivascular tumor of low malignant potential, with an incidence rate of 0.5-1% of all sinonasal tumors. It often shows local recurrences with invasion to the surrounding bony tissues. It usually arises from the perivascular cells surrounding the capillaries. Etiology of the tumour is uncertain, with few postulated hypothesis like pregnancy, trauma, hypertension and corticosteroid drugs. They have an indolent course and tend to occur most commonly in the adults of seventh decade of life. We present a case report of 55 years old male presenting to the ENT OPD, with complaints of right sided nasal obstruction and repeated episodes of epistaxis since the last 9 months. History and general examination was unremarkable except for antihypertensive intake since the last few years. Laboratory investigations showed microcytic hypochromic anaemia, raised absolute eosinophil count of 1500 cells per microliter and positive Hepatitis B surface antigen (HBsAg) in the blood. Rhinoscopic examination showed a reddish brown nodular swelling in the right nasal cavity beneath the middle turbinate and hypertrophy of left nasal mucosa. CT imaging suggested an 18x15 mms, well defined soft tissue mass in the right nasal cavity. Complete resection of the mass with endoscopic surgery was performed. Histopathological examination coupled with immunohistochemistry confirmed the diagnosis of Sinonasal Hemangiopericytoma. This case report stresses upon various differential diagnosis of sinonasal swellings and the importance of considering long term follow up of Sinonasal Hemagiopericytoma.