Helicobacter pylori antibodies in patients with psoriasis

Halasz, Charles L.

doi:10.1001/archderm.132.1.95

Cited by 8 publications

(4 citation statements)

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“…The number of individuals in each age group (from 20 to 80 years) was comparable in both studies. In contrast, in patients with psoriasis who were younger than 50 years of age, only 4% showed antibodies directed against H. pylori [25]. In addition, we assessed H. pylori seropositivity in our laboratory staff (mean age 30.0±5.7 years) and found seropositivity in only 11% of subjects (n = 28, not shown) whereas 60% of similar aged subjects with chronic urticaria showed antibodies specific for H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori–Associated Gastritis in Chronic Urticaria

Wedi¹,

Wagner

Werfel³

et al. 1998

Int Arch Allergy Immunol

126

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Background: Chronic urticaria and concurrent angioedema are frustrating problems for both physicians and patients. Methods: 100 patients with chronic urticaria (mean duration 33.3±48.2 months) attending the urticaria consulting hour of our Department of Dermatology within 1 year were carefully analyzed for pathogenesis to avoid extensive unnecessary diagnostic approach in the future. Results: In 43 cases a potential infectious trigger could be identified, 35 were of idiopathic origin, and 15 demonstrated pseudoallergic reactions to acetylsalicylic acid or food additives, 5 had antibodies to thyroid gland, and 2 had malignant diseases. Of patients with foci, 26 had Helicobacter pylori–associated gastritis, 9 chronic tonsillitis or sinusitis, 4 infections with Epstein–Barr virus or cytomegalovirus, 2 dental focal infections and 2 suffered from Yersinia infection. High prevalence of H. pylori gastritis was found since 47% of patients showed elevated H. pylori–specific IgA and/or IgG antibodies. 27 patients underwent endoscopy and in all but 1 (96%) antral H. pylori infection was found. In contrast, a prevalence rate of 37% among asymptomatic adults has been published. Disappearance (67%) or improvement of urticaria (24%) occurred in most antimicrobially treated patients after 3–12 weeks. In contrast, only 50% of untreated H. pylori–seropositive patients with chronic urticaria showed spontaneous remission or improvement within 12 weeks. Prevalence of H. pylori infection may even be underestimated since only 27/100 patients underwent endoscopy. It is suggested that H. pylori infection may be present at least in all seropositive subjects (47%). Moreover, we found H. pylori infection in 2 seronegative subjects demonstrating gastric complaints. Conclusions: Thus, measurement of H. pylori–specific antibodies and/or gastroscopy should be included in the diagnostic management of chronic urticaria to identify patients who may profit from eradication treatment with disappearance of long–standing and annoying urticaria symptomatology.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori–Associated Gastritis in Chronic Urticaria

Wedi¹,

Wagner

Werfel³

et al. 1998

Int Arch Allergy Immunol

126

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“…7 Also Halasz CL in 1996 showed that the prevalence of IgG against H pylori was in 54% of psoriatic patients, but this study had no control group for comparison. 8 In a study by Onsun et al 9 in 2012, 300 patients with psoriasis and 150 healthy individuals were enrolled. The PASI score in patients infected with H pylori was clearly higher, and simultaneous treatment of psoriasis and H pylori in patients with psoriasis was more effective than psoriasis treatment alone.…”

Section: Discussionmentioning

confidence: 99%

Relationship betweenHelicobacter pyloriinfection and psoriasis

Azizzadeh¹,

Nejad²,

Ghorbani³

et al. 2014

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVESPsoriasis is a chronic inflammatory skin disease for which no specific reason has been found although various reasons have been suggested. Helicobacter pylori is a Gram-negative bacterium, which is essentially considered the cause of acute and chronic gastritis. Recently, several reports have suggested that H pylori could play a role in triggering psoriasis. The aim of this study was to determine the relationship between H pylori seropositivity and psoriasis.DESIGN AND SETTINGSThis was a case-control study performed on patients with psoriasis vulgaris and healthy individuals in Fatemiye Hospital (referral center for the treatment of skin diseases), Semnan, Iran, during April 2011 to April 2012.METHODSA case-control study including 61 patients with psoriasis vulgaris (case group) and 61 healthy individuals (control group) without any known gastrointestinal complications were enrolled. All cases were tested for H pylori infection with serology (immunoglobulin G [IgG] anti-H pylori) using the enzyme-linked immunosorbent assay method.RESULTSTen (16.4%) of the psoriatic patients and 8 (13%) of the control groups had an H pylori seropositive test result; the average of IgG serum level was 17.3 IU/ML in psoriatic patients and 16.1 IU/ML in the control group. The difference of serum level between the 2 groups was not meaningful (P=.302).CONCLUSIONSOur finding indicated that there was neither a significant relationship between psoriasis and the serum level of IgG anti-H pylori, nor a significant relationship between psoriasis severity and the serum level of IgG anti-H pylori. Further studies should be designed to find out whether infection with H pylori is one of the reasons causing or aggravating psoriasis.

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“…Psoriasis is a chronic, non-contagious inflammatory skin disease, with genetic and autoimmune characteristics that affects the skin and joints[ 63 , 64 ]. Its association with H. pylori infection had already been investigated with the search for antibodies against H. pylori in patients with psoriasis without known gastrointestinal complaints[ 65 ]. Recently, a meta-analysis found a strong evidence demonstrating this association (OR = 1.19, 95%CI: 1.15-2.52, P = 0.008) and highlighted that the rate of H. pylori infection, interestingly, was significantly high in patients with moderate and severe psoriasis (OR = 2.27; 95%CI: 1.42-3.63, I 2 = 27%) but not in patients with the milder disease (OR = 1.10; 95%CI: 0.79-1.54, I 2 = 0%)[ 66 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

Helicobacter pylori infection: Beyond gastric manifestations

Santos

Brito

Silva

et al. 2020

WJG

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Helicobacter pylori ( H. pylori ) is a bacterium that infects more than a half of world’s population. Although it is mainly related to the development of gastroduodenal diseases, several studies have shown that such infection may also influence the development and severity of various extragastric diseases. According to the current evidence, whereas this bacterium is a risk factor for some of these manifestations, it might play a protective role in other pathological conditions. In that context, when considered the gastrointestinal tract, H. pylori positivity have been related to Inflammatory Bowel Disease, Gastroesophageal Reflux Disease, Non-Alcoholic Fatty Liver Disease, Hepatic Carcinoma, Cholelithiasis, and Cholecystitis. Moreover, lower serum levels of iron and vitamin B12 have been found in patients with H. pylori infection, leading to the emergence of anemias in a portion of them. With regards to neurological manifestations, a growing number of studies have associated that bacterium with multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Guillain-Barré syndrome. Interestingly, the risk of developing cardiovascular disorders, such as atherosclerosis, is also influenced by the infection. Besides that, the H. pylori -associated inflammation may also lead to increased insulin resistance, leading to a higher risk of diabetes mellitus among infected individuals. Finally, the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism. In this sense, this minireview aims to gather the main studies associating H. pylori infection with extragastric conditions, and also to explore the main mechanisms that may explain the role of H. pylori in those diseases.

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Helicobacter pylori antibodies in patients with psoriasis

Cited by 8 publications

References 0 publications

Prevalence of Helicobacter pylori–Associated Gastritis in Chronic Urticaria

Prevalence of Helicobacter pylori–Associated Gastritis in Chronic Urticaria

Relationship betweenHelicobacter pyloriinfection and psoriasis

Helicobacter pylori infection: Beyond gastric manifestations

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