Fluconazole constitutes an alternative but, because of greater availability and lower cost, griseofulvin remains the treatment of choice for tinea capitis.
A 45‐year‐old woman from Afghanistan presented with a 1‐year history of multiple itching and stinging lesions on both right and left auricular and periauricular areas. Skin examination revealed about eight superficial erythematous nodules, ranging from 0.2 to 1.2 cm in diameter, on both ears, as well as on the preauricular and retroauricular areas (Fig. 1). 1 Multiple erythematous nodules and papules on the left auricular and periauricular areas Examination of a lesional skin biopsy specimen revealed vascular proliferation and dense dermal infiltration by lymphocytes, eosinophils, and mast cells. The vascular component consisted of thick‐ and thin‐walled blood vessels lined by plump endothelial cells with large nuclei and abundant eosinophilic cytoplasm. No lymphoid follicles were identified (Fig. 2). 2 Diffuse dermal infiltration by lymphocytes and eosinophils and vascular proliferation (hematoxylin and eosin, (a) × 150, (b) × 250) The patient's medical history was remarkable for the gradual development of generalized edema starting 4 months after the appearance of the skin lesions. Laboratory investigation revealed the presence of massive proteinuria (11 g/day; normal, < 150 mg/day) and hematuria (12 red blood cells/high‐power field; normal, < 1–2 red blood cells/high‐power field), in association with hypoproteinemia (3.7 g/dL; normal, 5.5–8 g/dL) and hypercholesterolemia (489 mg/dL; normal, 50–220 mg/dL). The blood urea nitrogen (14 mg/dL; normal, 5–23 mg/dL) and serum creatinine (0.8 mg/dL; normal, 0.6–1.6 mg/dL) levels were within normal limits. A pathologic study of a renal biopsy specimen confirmed the diagnosis of diffuse mesangial proliferative nephropathy (Fig. 3). 3 Kidney biopsy showing diffuse, mild, mesangial proliferation (hematoxylin and eosin, × 400)
BACKGROUND AND OBJECTIVESPsoriasis is a chronic inflammatory skin disease for which no specific reason has been found although various reasons have been suggested. Helicobacter pylori is a Gram-negative bacterium, which is essentially considered the cause of acute and chronic gastritis. Recently, several reports have suggested that H pylori could play a role in triggering psoriasis. The aim of this study was to determine the relationship between H pylori seropositivity and psoriasis.DESIGN AND SETTINGSThis was a case-control study performed on patients with psoriasis vulgaris and healthy individuals in Fatemiye Hospital (referral center for the treatment of skin diseases), Semnan, Iran, during April 2011 to April 2012.METHODSA case-control study including 61 patients with psoriasis vulgaris (case group) and 61 healthy individuals (control group) without any known gastrointestinal complications were enrolled. All cases were tested for H pylori infection with serology (immunoglobulin G [IgG] anti-H pylori) using the enzyme-linked immunosorbent assay method.RESULTSTen (16.4%) of the psoriatic patients and 8 (13%) of the control groups had an H pylori seropositive test result; the average of IgG serum level was 17.3 IU/ML in psoriatic patients and 16.1 IU/ML in the control group. The difference of serum level between the 2 groups was not meaningful (P=.302).CONCLUSIONSOur finding indicated that there was neither a significant relationship between psoriasis and the serum level of IgG anti-H pylori, nor a significant relationship between psoriasis severity and the serum level of IgG anti-H pylori. Further studies should be designed to find out whether infection with H pylori is one of the reasons causing or aggravating psoriasis.
Objectives. Herpes labialis is a common viral infection and characterized by recurrent vesicular lesion primarily on the lips and perioral skin. The aim of this study was to determine the epidemiological, clinical characteristics and trigger factors associated with recurrence herpes labialis in adult patients. Methods. This case-control study was conducted with the participation of one hundred adult patients and the same number of control. Data collected about demographics, clinical, as well as trigger factors from individuals who met inclusion criteria. Results. Seventy-four percent of cases and 34% of controls were female that showed significant difference (p < 0.001). Mean body mass index of patients was significantly higher than controls (25.9 ± 2.9 kg/m 2 versus 22.0 ± 2.9 kg/m 2 , p < 0.001). The most common location of the lesions during the last episode of infection was upper lip (65%). The number of lesions was single in 58% and multiple in 42% of patients. The frequency of episodes per year was more than two attacks each year in most patients (83%). Positive family history of recurrence herpes labialis was found in 50% and 20% of cases and controls respectively (p < 0.001). Emotional stress (61%), sunlight exposure (54%) and flu (37%) were the main triggering factors reported by the patients. Conclusions. This study revealed that recurrence herpes labialis is more common in women and on the upper lip. Family history of recurrence herpes labialis was positive significantly in patients. The most common trigger factors were stress, sunlight exposure, flu. Higher body mass index was a probable risk factors for recurrence herpes labialis.Eur Res J 2018
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