Relationship betweenHelicobacter pyloriinfection and psoriasis

Abstract

BACKGROUND AND OBJECTIVESPsoriasis is a chronic inflammatory skin disease for which no specific reason has been found although various reasons have been suggested. Helicobacter pylori is a Gram-negative bacterium, which is essentially considered the cause of acute and chronic gastritis. Recently, several reports have suggested that H pylori could play a role in triggering psoriasis. The aim of this study was to determine the relationship between H pylori seropositivity and psoriasis.DESIGN AND SETTINGSThis was a case-control study performed on patients with psoriasis vulgaris and healthy individuals in Fatemiye Hospital (referral center for the treatment of skin diseases), Semnan, Iran, during April 2011 to April 2012.METHODSA case-control study including 61 patients with psoriasis vulgaris (case group) and 61 healthy individuals (control group) without any known gastrointestinal complications were enrolled. All cases were tested for H pylori infection with serology (immunoglobulin G [IgG] anti-H pylori) using the enzyme-linked immunosorbent assay method.RESULTSTen (16.4%) of the psoriatic patients and 8 (13%) of the control groups had an H pylori seropositive test result; the average of IgG serum level was 17.3 IU/ML in psoriatic patients and 16.1 IU/ML in the control group. The difference of serum level between the 2 groups was not meaningful (P=.302).CONCLUSIONSOur finding indicated that there was neither a significant relationship between psoriasis and the serum level of IgG anti-H pylori, nor a significant relationship between psoriasis severity and the serum level of IgG anti-H pylori. Further studies should be designed to find out whether infection with H pylori is one of the reasons causing or aggravating psoriasis.

Helicobacter pyloriand extragastric diseases: A review

“…The association between H. pylori infection and psoriasis is still controversial. In fact some authors demonstrated neither a significant relationship between psoriasis and H. pylori [ 50 , 51 ], nor a significant relationship between psoriasis severity and the serum levels of IgG anti- H pylori [ 51 ] . However, other authors demonstrated that H. pylori infection is more common in patients with psoriasis than in healthy controls[ 52 , 53 ] and that prevalence of H. pylori infection was higher in patients with severe psoriasis (79%) compared to those with moderate (69.5%) or mild (46.2%) disease[ 53 , 54 ].…”

Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis

“…After reading the title and abstract, 109 records were excluded via the initial screening. We then screened the whole 34 articles and finally included 11 studies for analysis (1741 participants) [18,19,20,21,22,23,24,25,26,27,28]. Figure 1 details the selection and exclusion process.…”

“…Among the 11 studies included in the meta-analysis, three were cohort study [19,21,27], four were cross-sectional study [20,23,24,25] and four were case–control study [18,22,26,28]. The publication year of the involved studies varied from 2000 [18] to 2017 [27].…”

Association between psoriasis and Helicobacter pylori infection: A systematic review and meta-analysis

“…Five studies used H. pylori ELISA test; three studies used urea breath test, and one study used stool antigen test as H. pylori diagnostic method. Five studies [ 14 15 16 17 18 ] have excluded participants with GI complaints or diseases. Fathy et al .…”

“…In contrast, Azizzadeh et al . [ 15 ] did not find a significant relationship between H. pylori infection and psoriasis or a correlation between H. pylori IgG level and PASI score.…”