Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis

Abstract

Background and Objectives: To perform a systematic review and meta-analysis with the aim of determining the relationship between H. pylori infection and psoriasis. Methods: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. Results: The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of H. pylori infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15–2.52, P = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of H. pylori detection, a statistically significant increase of H. pylori infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of H. pylori infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42–3.63, I2 = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79–1.54, I2 = 0%). Conclusion: H. pylori infection is associated with psoriasis, and psoriasis patients with H. pylori infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices.

Reducing upper digestive bleeding risk in patients treated with direct oral anticoagulants and concomitant infection with <em>Helicobacter&nbsp;pylori</em>

“…The bioavailability of the prodrug is <7%, the rest being eliminated in the feces. After its absorption in the proximal small bowel, dabigatran etexilate reaches the liver where it is transformed into the active form after its cleavage by the serum and hepatic esterases (10). According to its pharmacokinetics, one can accept that the lower GI bleedings are more frequent with dabigatran, due to its topical effect on the mucosa leading to bleeding, especially on pre-existing gut lesions.…”

Review: Extragastric diseases andHelicobacter pylori

“…6 A systematic review evaluated the relationship between H pylori infection and obesity among Chinese adults. The prevalence of H pylori was 42% (95% CI, [37][38][39][40][41][42][43][44][45][46][47] and mean difference of BMI between subjects with and without H pylori infection was 0.94 (95% CI, −0.04 to 1.91). The OR value was 1.20 (95% CI, 1.13-1.…”

“…Moreover, H pylori prevalence increased significantly in patients with moderate and severe psoriasis (OR, 2.27; 95% CI, 1.42-3.63). 41 Another recent meta-analysis found that in H pylori-positive patients, antibiotic treatment induced chronic spontaneous urticaria remission independently of H pylori eradication. 42 In a prospective study, 57 consecutive patients (27 pityriasis versicolor, 30 telogen effluvium) screened for anti-H pylori and anti-CagA IgG, showed significantly higher rates of H pylori positivity in the pityriasis versicolor group than in the telogen effluvium group (P < .05).…”

Helicobacter pylori infection: Beyond gastric manifestations

“…Its association with H. pylori infection had already been investigated with the search for antibodies against H. pylori in patients with psoriasis without known gastrointestinal complaints[ 65 ]. Recently, a meta-analysis found a strong evidence demonstrating this association (OR = 1.19, 95%CI: 1.15-2.52, P = 0.008) and highlighted that the rate of H. pylori infection, interestingly, was significantly high in patients with moderate and severe psoriasis (OR = 2.27; 95%CI: 1.42-3.63, I 2 = 27%) but not in patients with the milder disease (OR = 1.10; 95%CI: 0.79-1.54, I 2 = 0%)[ 66 ]. Another disease commonly associated with H. pylori infection is chronic urticaria, a clinical condition that presents with itchy, erythematous or swollen urticaria[ 67 , 68 ].…”