Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

Wickström, Henrika; Broos, Anouk; Nyman, Johan; Kortesmäki, Ewelina; Eklund, Patrik; Beer, Thomas De; Preis, Maren; Sandler, Niklas

doi:10.1016/j.ijpharm.2017.08.036

Cited by 7 publications

(7 citation statements)

References 1 publication

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“…Loperamide and caffeine were used as model drugs in order to investigate the preparation of flexible doses by inkjet printing [14], whereas the utilization of different substrates for loading rasagiline mesylate has been reported [15] Paracetamol, theophylline and caffeine were printed in porous substrates, presenting an alternative approach to control the deposition and the crystallization of the drugs [16]. Levothyroxine has been formulated by inkjet printing in order to develop flexible pediatric dosage forms [17]. Combining inkjet printing with the Quick Response (QR) technology also seems very promising, as practical information is encoded in drug loaded QR patterns (expiration date, route of administration, batch number, and manufacturer ID) and smart dosage forms are being formed for every individual [18,19].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

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Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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“…Moreover, 2D inkjet printing technologies enable a precise spatial control over droplet ejection, enabling small and personalised dosages and patterns to be deposited onto oral substrates (Alomari et al, 2018;Buanz et al, 2011;Edinger et al, 2018;Edinger et al, 2019;Sandler and Preis, 2016;Thabet et al, 2018;Vuddanda et al, 2018;Wickström et al, 2018).…”

Section: As a Results Of Global Initiatives Such As The European Unionmentioning

confidence: 99%

Track-and-trace: Novel anti-counterfeit measures for 3D printed personalized drug products using smart material inks

Trenfield

Tan

Awad

et al. 2019

International Journal of Pharmaceutics

100

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“…Color evaluation has a wide field of applications. It can be used in medicaments doses control [9], glucose detection [10], water quality control [3], gas detection [11] or pH determination [5]. The most common way to digitalize the color for its further evaluation consists in using a photographic camera [2], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, low-cost colorimeters integrated into circuit devices have become commercially available and performed well. Low-cost colorimeters can therefore be designed for several applications [9]- [11]. Unlike the problems associated with smartphone cameras, color measurement by colorimeter has the advantage of repeatability due to a controlled light condition.…”

Section: Introductionmentioning

confidence: 99%

Battery-Less NFC Sensor for pH Monitoring

et al. 2019

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In this paper, we present a low-cost battery-less color sensor based on Near Field Communication (NFC). This system consists of a color sensor connected to a low-power microcontroller connected to an NFC chip. The energy needed to power up the chipset is retrieved from the magnetic field generated by the reader, i.e., a commercial smartphone. The low cost of NFC chips affords the opportunity to manufacture low-cost tags with sensing capability. We have developed a mobile application to simultaneously present the data and send them to a database in the cloud. The system has been tested with several pH reactive strips. The pH was determined via color measurement using the HSV color space. A simple linear relationship was found between the Hue parameter and the pH. Comparison with the pH determination via smartphone camera showed that the accuracy was greater when the NFC colorimeter was used.

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Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

Cited by 7 publications

References 1 publication

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Track-and-trace: Novel anti-counterfeit measures for 3D printed personalized drug products using smart material inks

Battery-Less NFC Sensor for pH Monitoring

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