Guillain-Barre syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil

Lima, Matheus Eugênio de Sousa; Bachur, Tatiana Paschoalette Rodrigues; Aragão, Gislei Frota

doi:10.1016/j.actatropica.2019.105064

Cited by 26 publications

(14 citation statements)

References 27 publications

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“…A sudden outbreak of GBS was observed in 2018, in Peru, with the classical picture of GBS but with pain of the extremities, likely associated with an enterovirus infection [58]. More anecdotally, some GBS were reported during dengue or chikungunya epidemics [59]. Recently, some cases of acute polyradiculitis have been reported in association with COVID-19, akin to GBS due to other triggers [60].…”

Section: Guillain-barré Syndrome and Emerging Infectious Diseasesmentioning

confidence: 99%

Epidemics and outbreaks of peripheral nervous system disorders: I. infectious and immune-mediated causes

et al. 2020

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Section: Guillain-barré Syndrome and Emerging Infectious Diseasesmentioning

confidence: 99%

Epidemics and outbreaks of peripheral nervous system disorders: I. infectious and immune-mediated causes

et al. 2020

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“…Las complicaciones neurológicas de la infección por el virus del dengue se clasifican en tres categorías basadas en la patogenia, los trastornos producidos por una alteración metabólica, por la invasión viral, que incluye encefalitis, meningitis, miositis y mielitis; por reacciones autoinmunes, que incluyen encefalomielitis diseminada aguda, neuromielitis óptica, neuritis óptica, mielitis, encefalopatía y síndrome de Guillain-Barre (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) .…”

Section: Discussionunclassified

“…Las complicaciones neurológicas del dengue son más frecuentes con el serotipo 2 y el 3 (9) . Se ha relacionado al dengue como causa del SGB recientemente y cada vez se describen más casos (8)(9)(10)(11) . La patogenia del SGB, aún no se conoce por completo, se cree que las manifestaciones clínicas en el dengue se producen como consecuencia de una respuesta inmune alterada a antígenos no propios que pueden reaccionar de forma cruzada con la mielina o los axones de los nervios periféricos a través del mimetismo molecular, la respuesta de las células T activadas y la producción de citoquinas proinflamatorias, con componentes del complemento, favorecen, que los anticuerpos actúen sobre el compartimento endoneural y las células de Schwann, dando lugar al desarrollo del SGB (12)(13)(14)(15) .…”

Section: Discussionunclassified

Autoimmune manifestations in patients with dengue. Casuistry in the Internal Medicine Department of the Hospital Nacional, Paraguay

Jarolín

Taboada

Montiel

et al. 2020

Rev. Nac. (Itauguá)

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“…HEK 293T cells (human kidney cells) were infected with the pseudo particles CHIKV-mCherry-490 with a multiplicity of infection of 1 (MOI = 1) in the Chikungunya fever is characterized by strong fever, arthralgia, backache, headache, and fatigue. In some cases, cutaneous manifestation and neurological complications can occur [19,20]. There is no Food and Drug Administration (FDA) approved specific antiviral or vaccine against CHIKV.…”

Section: Epigallocatechin Gallate (Green Tea)mentioning

confidence: 99%

Antivirals Against Chikungunya Virus: Is the Solution in Nature?

Martins

Santos

Oliveira

et al. 2020

Viruses

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The worldwide outbreaks of the chikungunya virus (CHIKV) in the last years demonstrated the need for studies to screen antivirals against CHIKV. The virus was first isolated in Tanzania in 1952 and was responsible for outbreaks in Africa and Southwest Asia in subsequent years. Between 2007 and 2014, some cases were documented in Europe and America. The infection is associated with low rates of death; however, it can progress to a chronic disease characterized by severe arthralgias in infected patients. This infection is also associated with Guillain-Barré syndrome. There is no specific antivirus against CHIKV. Treatment of infected patients is palliative and based on analgesics and non-steroidal anti-inflammatory drugs to reduce arthralgias. Several natural molecules have been described as antiviruses against viruses such as dengue, yellow fever, hepatitis C, and influenza. This review aims to summarize the natural compounds that have demonstrated antiviral activity against chikungunya virus in vitro.Viruses 2020, 12, 272 2 of 17 CHIKV belongs to the Alphavirus genus and the Togaviridae family. It is a positive-sense, single-stranded RNA (12 kb in length) virus, with an enveloped icosahedral capsid [10]. The virus lifecycle starts via the attachment of the viral glycoproteins to the cell membrane receptors, mainly to MXRA8 [11,12] but also to prohibitin (PHB) [13], phosphatidylserine (PtdSer) [14], and glycosaminoglycans (GAGs) [15] receptors in mammalian and to ATP synthase β in mosquito cells [16], forming a pore. Then, a virus capsid is released into the cytoplasm, where the replication process takes place. Viral genome is uncoated and directly translated into nonstructural (NS) proteins nP1-4. The NS proteins form the viral replicase complex that catalyzes the synthesis of a negative strand, a template to synthesize the full-length positive sense genome, and the subgenomic mRNA. The subgenomic mRNA is translated in a polyprotein, which is cleaved to produce the structural proteins C, E3, E2, 6k, and E1, followed by the assembly of the viral components and virus release (Figure 1) [17,18].

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Guillain-Barre syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil

Cited by 26 publications

References 27 publications

Epidemics and outbreaks of peripheral nervous system disorders: I. infectious and immune-mediated causes

Epidemics and outbreaks of peripheral nervous system disorders: I. infectious and immune-mediated causes

Autoimmune manifestations in patients with dengue. Casuistry in the Internal Medicine Department of the Hospital Nacional, Paraguay

Antivirals Against Chikungunya Virus: Is the Solution in Nature?

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