Growth Promotion of Mycelia of the Matsutake Mushroom<i>Tricholoma matsutake</i>by<scp>D</scp>-Isoleucine

Kawagishi, Hirokazu; Hamajima, Keiko; Takanami, Ryo; Nakamura, Tomoyuki; Sato, Yuko; Akiyama, Yukihito; Sano, Masanori; Tanaka, Osamu

doi:10.1271/bbb.68.2405

Cited by 21 publications

(12 citation statements)

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“…Addition of D-Ile to the culture medium strikingly promoted mycelial growth of Matsutake mushrooms (Kawagishi et al 2004). D-Leu, D-Ile, and D-Val enhanced the activity of prolinase in erythrocytes of a prolidasedeficient patient (Wang et al 2004).…”

Section: Isoleucine Stereoisomers (D-ile L-allo-ile and D-allo-ile)mentioning

confidence: 99%

Nutritional and medicinal aspects of d-amino acids

2011

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This paper reviews and interprets a method for determining the nutritional value of D-amino acids, D-peptides, and amino acid derivatives using a growth assay in mice fed a synthetic all-amino acid diet. A large number of experiments were carried out in which a molar equivalent of the test compound replaced a nutritionally essential amino acid such as L-lysine (L-Lys), L-methionine (L-Met), L-phenylalanine (L-Phe), and L-tryptophan (L-Trp) as well as the semi-essential amino acids L-cysteine (L-Cys) and L-tyrosine (L-Tyr). The results show wide-ranging variations in the biological utilization of test substances. The method is generally applicable to the determination of the biological utilization and safety of any amino acid derivative as a potential nutritional source of the corresponding L-amino acid. Because the organism is forced to use the D-amino acid or amino acid derivative as the sole source of the essential or semi-essential amino acid being replaced, and because a free amino acid diet allows better control of composition, the use of all-amino-acid diets for such determinations may be preferable to protein-based diets. Also covered are brief summaries of the widely scattered literature on dietary and pharmacological aspects of 27 individual D-amino acids, D-peptides, and isomeric amino acid derivatives and suggested research needs in each of these areas. The described results provide a valuable record and resource for further progress on the multifaceted aspects of D-amino acids in food and biological samples.

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Section: Isoleucine Stereoisomers (D-ile L-allo-ile and D-allo-ile)mentioning

confidence: 99%

Nutritional and medicinal aspects of d-amino acids

2011

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“…With respect to the growth of matsutake in liquid medium, Kawagishi et al (2004) found that the addition of D-isoleucine to the culture medium of matsutake significantly enhanced mycelia growth. Kim et al (2010) investigated the optimal medium composition of liquid culture with the goal of shortening the culture period and to maximise polysaccharide production and mycelial growth of matsutake.…”

Section: Matsutakementioning

confidence: 99%

Mycorrhizal Fungi: Use in Sustainable Agriculture and Land Restoration

Solaiman¹,

Abbott²,

Varma³

2014

Soil Biology

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“…D -Branched-chain amino acids ( D -BCAAs) such as D -isoleucine, D -leucine, and D -valine are known to exhibit special bioactivities ( Kawagishi et al, 2004 ; Wang et al, 2004 ; Kolodkin-Gal et al, 2010 ), and are used as intermediates for several antibiotics ( Velkov et al, 2010 ; Tempelaars et al, 2011 ; Doveston et al, 2012 ). For one step production of D -BCAAs from the corresponding 2-oxo acids, we developed a two enzyme-coupled system composed of D -AADH and glucose dehydrogenase (GDH) from the thermoacidophilic crenarchaeon Sulfolobus tokodaii ( Figure 2A ; Ohshima et al, 2003 ).…”

Section: Production Of D -Bcaas and Their Stable Imentioning

confidence: 99%

Artificial Thermostable D-Amino Acid Dehydrogenase: Creation and Application

et al. 2018

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Many kinds of NAD(P)+-dependent L-amino acid dehydrogenases have been so far found and effectively used for synthesis of L-amino acids and their analogs, and for their sensing. By contrast, similar biotechnological use of D-amino acid dehydrogenase (D-AADH) has not been achieved because useful D-AADH has not been found from natural resources. Recently, using protein engineering methods, an NADP+-dependent D-AADH was created from meso-diaminopimelate dehydrogenase (meso-DAPDH). The artificially created D-AADH catalyzed the reversible NADP+-dependent oxidative deamination of D-amino acids to 2-oxo acids. The enzyme, especially thermostable one from thermophiles, was efficiently applicable to synthesis of D-branched-chain amino acids (D-BCAAs), with high yields and optical purity, and was useful for the practical synthesis of 13C- and/or 15N-labeled D-BCAAs. The enzyme also made it possible to assay D-isoleucine selectively in a mixture of isoleucine isomers. Analyses of the three-dimensional structures of meso-DAPDH and D-AADH, and designed mutations based on the information obtained made it possible to markedly enhance enzyme activity and to create D-AADH homologs with desired reactivity profiles. The methods described here may be an effective approach to artificial creation of biotechnologically useful enzymes.

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Growth Promotion of Mycelia of the Matsutake MushroomTricholoma matsutakebyD-Isoleucine

Cited by 21 publications

References 1 publication

Nutritional and medicinal aspects of d-amino acids

Nutritional and medicinal aspects of d-amino acids

Mycorrhizal Fungi: Use in Sustainable Agriculture and Land Restoration

Artificial Thermostable D-Amino Acid Dehydrogenase: Creation and Application

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