Growth Hormone Gene Polymorphism and Its Association with Partial Cumulative Milk Yields of Holstein Friesian Dairy Cattle

Misrianti, Restu; Anggraeni, Anneke; Andreas, E.; Sumantri, Cece

doi:10.5398/medpet.2012.35.3.145

Cited by 3 publications

(3 citation statements)

References 21 publications

(26 reference statements)

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“…Pal et al [14] showed that crossbred males with the bGH-AluI LL genotype demonstrated higher expected milk productivity. It was shown in other studies on Holstein cows that the total milk yield in animals with the bGH-AluI LV and bGH-AluI VV genotypes was significantly higher than in cows with the bGH-AluI LL genotype, which suggests the dominance of the bGH-AluI V allele [15][16][17][18]. Our results also showed that black-and-white cows with the bGH-Alu-I LV genotype have higher milk yield.…”

Section: Discussionsupporting

confidence: 73%

Preferred and undesirable genotypes of bGH and bIGF-1 genes for the milk yield and quality of black-and-white breed

et al. 2021

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Background and Aim: The market demand for the quality of milk and dairy products, in particular in terms of such indicators as fat content, the amount and composition of milk protein, etc., is growing. Thus, the need for the selection of dairy herds using genetic markers associated with qualitative traits of milk productivity is becoming urgent. This study aimed to determine the preferred and undesirable genotypes of the AluI polymorphism of the growth hormone gene and SnaBI polymorphism of the insulin-like growth factor-1 gene associated with milk productivity and quality indicators of the black-and-white breed. The genotypes of animals were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Materials and Methods: Samples of the black-and-white breed from Kazakhstan served as the research subjects. The polymorphism of the growth hormone and insulin-like growth factor-1 genes was determined by PCR-RFLP. The relationship of bGH-AluI and bIGF-1-SnaBI polymorphisms with productivity was assessed (fat, protein, and milk yield for 305 days of lactation, live weight, somatic cells, and milk production coefficient) by analysis of variance using Statistica 6.0 software. Results: The black-and-white cows with the bGH-AluILV genotype had significantly higher milk yield in 305 days (3174.5±157.2 kg) than those with the bGH-AluILL (2940.0±152.6 kg) and bGH-AluIVV genotypes (2964.0±36.0; p<0.05). The milk fat content of cows with genotypes bGH-AluILV and bGH-AluILL (121.8±6.5 and 120.6±10.2, respectively) was significantly higher than those with bGH-AluIVV genotype (109.8±10.8; p<0.05). The black-and-white cows with the bGH-AluILV genotype (96.7±5.3) had significantly more milk protein than those with the bGH-AluILL (90.3±5.6) and bGH-AluIVV (86.9±4.6) genotypes (p<0.05). There were no statistically significant differences in the indicators of milk productivity of cows with different genotypes of bIGF-1-SnaBI polymorphism. Conclusion: The results showed that the bGH-AluILV genotype was preferred for the black-and-white breed. The study demonstrated that genotype determined the relevant qualities, while the conditions of feeding, maintenance, and industrial technology provided the manifestation of this genotype. Thus, cows of the same (Wis Burke Ideal) line, having common ancestors in close (IV–V) ranks but living in different farming conditions, had large differences in milk productivity level. The variation was 2046 kg or 67.6% of milk per lactation.

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Section: Discussionsupporting

confidence: 73%

Preferred and undesirable genotypes of bGH and bIGF-1 genes for the milk yield and quality of black-and-white breed

et al. 2021

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“…Previous study of genetic diversity of the GH gene|AluI in HF dairy cattle at the same these livestock breeding stations by Misrianti et al (2012) reported that all HF cattle observed had only two genotypes, namely LL and LV genotypes, without VV genotype. Frequencies of the LL genotype reported very high compared to the LV genotype, were 0.84-0.95 vs. 0.05 to 0.16.…”

Section: Genotype and Allele Frequencies Of The Ghrh Genementioning

confidence: 91%

GHRH|HaeIII Gene Polymorphism in Dairy and Beef Cattle at National Livestock Breeding Centers

Rini¹,

Sumantri²,

Anggraini³

2013

Med Pet

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ABSTRACT), kecuali pada sapi FH di BIB Lembang, sapi Brahman, dan Angus di BET Cipelang. Nilai heterozigositas tertinggi adalah 0,471 untuk sapi FH pejantan di BIB Lembang, sebaliknya, nilai terendah adalah 0,344 untuk sapi FH pejantan di BBIB Singosari. Nilai heterozigositas sapi FH lebih rendah daripada sapi Simmental dan Limousin. Gen GHRH pada sapi FH dan sapi pedaging menunjukkan polimorfik, kecuali pada sapi Brahman yang hanya memiliki alel B.

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“…Similar results were observed in other Holstein populations from different countries. Frequency of genotype VV was found low or none in different Holstein populations [30][31][32][33] .…”

Section: Discussionmentioning

confidence: 90%

GH-AluI ve MYF5-TaqI Polimorfizmlerinin Erkek Holstein Buzağılarında Sütten Kesim Ağırlığı ve Vücut Ölçüleri Üzerine Etkileri

Çınar¹,

Akyüz²,

Kiyici³

et al. 2018

Kafkas Univ Vet Fak Derg

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Live weight and body measurements are economically important quantitative traits that affect carcass yield and calf survival in cattle. Four genes, growth hormone gene (GH), myogenic factor 5 (MYF5), fatty acid binding protein 4 (FABP4) and signal transducers and activators of transcription 5A (STAT5A) were chosen as candidate genes for live weight and body measurements due to their important role in growth. The aims of this study were to genotype GH-AluI, MYF5-TaqI, FABP4-HinII and STAT5A-AvaI polymorphisms and to investigate their associations with live weights and body measurements in Holstein young bulls. Genotyping of the single nucleotide polymorphism (SNP) markers in these candidate genes was carried out using the restriction fragment length polymorphism (RFLP) analysis. Frequencies of L allele for GH, A allele for MYF5, G allele for FABP4 and C allele for STAT5A were, 0.96, 0.61, 0.79 and 0.74, respectively in the examined animals. The regression analysis indicated that the GH-AluI polymorphism showed an association with weaning weight (WW), 180 th day weight and hearth girth from birth to 180 days of age. The MYF5-TaqI polymorphism was found to influence body length at birth and birth weight (BW). However, no significant association was detected between the FABP4-HinII genotypes and measured traits. The GH-AluI and MYF5-TaqI polymorphisms may be useful for selection on live weight and body measurement traits in Holstein young bulls.

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Growth Hormone Gene Polymorphism and Its Association with Partial Cumulative Milk Yields of Holstein Friesian Dairy Cattle

Abstract: Growth hormone gene (GH gene) plays an important role in regulating body growth and in developing mammary gland, similar with its interaction to specific receptors. The GH gene has been considered as one of candidate gene associated with selection on lactation trait and milk production.

Cited by 3 publications

References 21 publications

Preferred and undesirable genotypes of bGH and bIGF-1 genes for the milk yield and quality of black-and-white breed

Preferred and undesirable genotypes of bGH and bIGF-1 genes for the milk yield and quality of black-and-white breed

GHRH|HaeIII Gene Polymorphism in Dairy and Beef Cattle at National Livestock Breeding Centers

GH-AluI ve MYF5-TaqI Polimorfizmlerinin Erkek Holstein Buzağılarında Sütten Kesim Ağırlığı ve Vücut Ölçüleri Üzerine Etkileri

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