Gray and white matter volumetric and diffusion tensor imaging (DTI) analyses in the early stage of first-episode schizophrenia

Diffusion Tensor Imaging Analysis for Psychiatric Disorders

“…11 In the early stage of theˆrst episode of schizophrenia, MD shows a signiˆcant increase in the left parahippocampal gyrus, left insula, and right anterior cingulate gyrus without any reduction of brain volume or abnormalities of FA, so MD seems to be a useful marker for early schizophrenia. 12 This hypothesis is consistent with the result of another DTI investigation of a large cohort of patients withˆrst-episode schizophrenia, which conˆrmed a reduction of FA in the inferior longitudinal fasciculus alone. 13 Patients with schizophrenia also demonstrate abnormalities of the semantic network, which are identiˆed by DTI analysis as a decrease of signiˆcant FA in the left inferior frontal white matter and are revealed by functional MR imaging as weaker connectivity between the left inferior frontal gyrus and left middle temporal gyrus.…”

Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter

“…Douaud and colleagues 23 found less grey matter tissue in the Heschl gyrus, parietal operculum and the supplementary motor area and lower fractional anisotropy in a vast network of white matter tracts in patients with first-episode psychosis than in controls. Finally, Moriya and colleagues 35 did not find any significant difference in the amount of grey matter tissue or fractional anisotropy between patients with first-episode psychosis and controls. In line with the findings reported in these 3 studies, our results suggest that both grey and white matter changes are more pronounced in patients with firstepisode psychosis with younger age at onset than in those with older age at onset.…”

“…James and colleagues 6 and Douaud and colleagues 23 studied both grey matter VBM and white matter TBSS in adolescent patients, whereas Moriya and colleagues 35 studied grey matter VBM, and fractional anisotropy and mean diffusivity VBA in patients with first-episode psychosis between the ages of 13 and 52 (mean 30) years. James and colleagues 6 found globally less grey matter tissue and lower fractional anisotropy in a vast network of white matter tracts in patients with first-episode psychosis than in controls.…”

Anterior Cingulate Abnormality as a Neural Correlate of Mismatch Negativity in Schizophrenia

“…Many magnetic resonance imaging (MRI) studies of patients with schizophrenia have reported gray matter volume reductions in diverse areas [1,2,3]. In recent years, diffusion tensor imaging (DTI) studies have reported structural abnormalities in several fiber tracts [3,4,5,6,7], confirming that the structure of the white matter connecting gray matter regions is disrupted.…”

“…Many magnetic resonance imaging (MRI) studies of patients with schizophrenia have reported gray matter volume reductions in diverse areas [1,2,3]. In recent years, diffusion tensor imaging (DTI) studies have reported structural abnormalities in several fiber tracts [3,4,5,6,7], confirming that the structure of the white matter connecting gray matter regions is disrupted. In particular, disruptions between the cingulate gyrus and other regions have been demonstrated [8,9,10,11], and these may be associated with the symptoms of schizophrenia [12,13,14].…”