Graphene Oxide as a Multifunctional Platform for Raman and Fluorescence Imaging of Cells

Zhang, Zhenyu; Liu, Qinghai; Gao, Dongliang; Luo, Da; Niu, Yang; Yang, Juan; Li, Yan

doi:10.1002/smll.201403459

Cited by 33 publications

(32 citation statements)

References 65 publications

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“…Biomolecule detection [96][97][98][99][100][101][102][103][104][105], cell/tissue imaging [150,151] (standard deviation of the response (σ)/slope of the calibration curve (S))) of 100 pM. They also demonstrated that the GO-based sensing platform is feasible to detect metal ion as well as small molecules when complemented with the use of each known aptamer.…”

Section: Chemical Enhancement In Sers Induced By Electron Transfermentioning

confidence: 97%

“…This system enabled the label-free detection of HIV DNA with the femtomolar concentration level and MRSA bacteria with LOD of 10 CFU/mL. In addition, the various GO-noble metal nanocomposites have been widely applied to detect extremely small amount of pigments in food, H 2 O 2 , glucose, and polar antibiotics [98][99][100][101][102][103]. In addition to its role in the enhancement of SERS signal, the combination of graphene with metal nanoparticles has been used as a favorable hybrid structure for preventing the surface oxidation of metal nanoparticles [104,105].…”

Section: Sers-based Biosensorsmentioning

confidence: 99%

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Biosensors based on graphene oxide and its biomedical application

Lee

Kim

et al. 2016

Advanced Drug Delivery Reviews

326

173

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Graphene oxide (GO) is one of the most attributed materials for opening new possibilities in the development of next generation biosensors. Due to the coexistence of hydrophobic domain from pristine graphite structure and hydrophilic oxygen containing functional groups, GO exhibits good water dispersibility, biocompatibility, and high affinity for specific biomolecules as well as properties of graphene itself partly depending on preparation methods. These properties of GO provided a lot of opportunities for the development of novel biological sensing platforms, including biosensors based on fluorescence resonance energy transfer (FRET), laser desorption/ionization mass spectrometry (LDI-MS), surface-enhanced Raman spectroscopy (SERS), and electrochemical detection. In this review, we classify GO-based biological sensors developed so far by their signal generation strategy and provide the comprehensive overview of them. In addition, we offer insights into how the GO attributed in each sensor system and how they improved the sensing performance.

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Section: Chemical Enhancement In Sers Induced By Electron Transfermentioning

confidence: 97%

Section: Sers-based Biosensorsmentioning

confidence: 99%

Biosensors based on graphene oxide and its biomedical application

Lee

Kim

et al. 2016

Advanced Drug Delivery Reviews

326

173

View full text Add to dashboard Cite

show abstract

“…Despite recent advances in traditional clinical diagnostic techniques (including magnetic resonance imaging, ultrasound imaging, computed tomography and positron emission tomography), the accuracy and sensitivity of diagnosis are still poor during the early stages of cancer, when the tumor is only a few cells in size [ 6 , 7 ]. In this context, the combination of enhanced Raman scattering and fluorescence methods, which uses nanomaterials as a probe for optical image of early-stage cancer, has come to be regarded as a promising alternative strategy, as it can achieve single-molecule imaging with excellent sensitivity and selectivity [ 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Homologous Gold Nanoparticles and Nanoclusters Composites with Enhanced Surface Raman Scattering and Metal Fluorescence for Cancer Imaging

Yan

Duan

et al. 2018

Nanomaterials

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A large number of deaths from cancer can be attributed to the lack of effective early-stage diagnostic techniques. Thus, accurate and effective early diagnosis is a major research goal worldwide. With the unique phenomenon of localized surface plasmon resonance (LSPR), plasmonic nanomaterials have attracted considerable attention for applications in surface-enhanced Raman scattering (SERS) and metal-enhanced fluorescence (MEF). Both SERS and MEF are ultra-sensitive methods for the detection and identification of early tumor at molecular level. To combine the merits of the fast and accurate imaging of MEF and the stable and clear imaging of SERS, we propose a novel dual functional imaging nanoprobe based on gold nanoparticles and gold nanocluster composites (denoted AuNPC-RGD). The gold nanoparticles are used as LSPR substrates to realized enhancement of Raman or fluorescence signal, while the gold nanoclusters serve as a fluorophore for MEF imaging, and exhibit better biocompatibility and stability. Furthermore, target molecule of cyclic Arg-Gly-Asp (cRGD) is incorporated into the composite to improve delivery efficiency, selectivity and imaging accuracy. These integrated properties endow AuNPC-RGD composites with outstanding biocompatibility and excellent imaging abilities, which could be used to achieve accurate and effective diagnosis for early cancer.

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“…Zhang et al utilized GO as a platform to synthesize GO@ AuNPs or dye hybrids for fluorescence and SERS imaging of cells based on the optical properties of fluorescent dyes and characteristic fingerprints of GO, respectively, for Raman applications. 16 In addition, GO can also be used as the coating material of…”

Section: Introductionmentioning

confidence: 99%

Development of graphene oxide-wrapped gold nanorods as robust nanoplatform for ultrafast near-infrared SERS bioimaging

Qiu¹,

You²,

Chen³

et al. 2017

IJN

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The rapid development of near-infrared surface-enhanced Raman scattering (NIR SERS) imaging technology has attracted strong interest from scientists and clinicians due to its narrow spectral bandwidth, low background interference, and deep imaging depth. In this report, the graphene oxide (GO)-wrapped gold nanorods (GO@GNRs) were developed as a smart and robust nanoplatform for ultrafast NIR SERS bioimaging. The fabricated GO@ GNRs could efficiently load various NIR probes, and the in vitro evaluation indicated that the nanoplatform could exhibit a higher NIR SERS activity in comparison with traditional gold nanostructures. The GOs were prepared by directly pyrolyzing citric acid for greater convenience, and GO@GNRs were fabricated via a facile synthesis strategy. Higher NIR SERS activity, facile synthesis method, excellent biocompatibility, and superb stability make the GO@GNRs/probe complex promising nanoprobes for NIR SERS-based bioimaging applications.

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Graphene Oxide as a Multifunctional Platform for Raman and Fluorescence Imaging of Cells

Cited by 33 publications

References 65 publications

Biosensors based on graphene oxide and its biomedical application

Biosensors based on graphene oxide and its biomedical application

Homologous Gold Nanoparticles and Nanoclusters Composites with Enhanced Surface Raman Scattering and Metal Fluorescence for Cancer Imaging

Development of graphene oxide-wrapped gold nanorods as robust nanoplatform for ultrafast near-infrared SERS bioimaging

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