Biosensors based on graphene oxide and its biomedical application

Lee, Jieon; Kim, Jungho; Kim, Seongchan; Min, Dal‐Hee

doi:10.1016/j.addr.2016.06.001

Cited by 326 publications

(189 citation statements)

References 155 publications

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“…It has been widely used in chemical sensing, tissue engineering, or as fluorescent probes . Two‐dimensional materials graphene has been widely studied by researchers in sensors, batteries, and biomedicine in recent years as a result of its excellent physical, mechanical, and chemical performances . On account of its piezoelectricity and physiological compatibility, PHA may be better suited for biomedical use by combining it with graphene .…”

Section: Synthesis Of Polyhydroxyalkanoatesmentioning

confidence: 99%

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Luo

Liu

et al. 2019

Biotechnology Journal

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In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers. This review summarizes the synthesis of PHA copolymers by the latest biosynthetic and chemical modification methods. The modified PHA copolymer could greatly reduce the production cost with elevated mechanical or physicochemical properties, which can further meet the practical needs of various fields. This review further summarizes the broad applications of modified PHA copolymers in biomedical applications, which might shred lights on their commercial applications.

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Section: Synthesis Of Polyhydroxyalkanoatesmentioning

confidence: 99%

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Luo

Liu

et al. 2019

Biotechnology Journal

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“…[60] Moreover, this biosensing mechanism has been extended to aptamer selection, [61] evanescent wave aptasensors, [62] peptide-based biosensing platforms, [63] biomolecular logic gates operations, [64,65] in situ live cell sensing, [66][67][68] and drug monitoring. [31,51,[72][73][74] Hence, we will focus this section on a critical overview of biosensing approaches involving the solid phase and label-free techniques by discussing representative examples from the functional point of view, that is, highlighting the critical role of GO. Overall, these GO-based approaches are widely covered by recent review articles.…”

Section: Innovative Trends Of Go In Optical Biosensingmentioning

confidence: 99%

“…The authors highlighted that the enhanced refractive index sensitivity relies on induced surface dipole due to the charge transfer between the metallic film and pristine graphene. [74,106] Particularly, graphene derivatives-based SERS substrates enable the following advantages: i) a fluorescence-quenching nature offering the capability to analyze fluorescent analytes, even using an excitation laser close to the excitation wavelength of the analyte. [98] In fact, GO-coated SPR substrates have been reported to outperform the bioanalytical sensitivity of commercially available biochips containing a 3D linker.…”

Section: Go In Label-free Optical Biosensingmentioning

confidence: 99%

“…They also concluded that the SPR sensitivity was observed to be proportional to the thickness of the explored GO coating. [117] Notably, the literature describes particular SERS applications of composites-incorporating GO in several fields, [31,74] including bio-imaging, [117,118] biomarkers detection, [119][120][121] bacteria determination, [121] pesticides monitoring, [122] and food analysis among others. [102] In this regard, surface-enhanced Raman spectroscopy (SERS) can also be exploited as a powerful label-free bioanalytical platform based on vibrational spectroscopy.…”

Section: Go In Label-free Optical Biosensingmentioning

confidence: 99%

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Graphene Oxide as an Optical Biosensing Platform: A Progress Report

2018

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IntroductionAs a 2D material, graphene oxide (GO) is a lattice-like nanostructure of hexagonal carbon rings disrupted by oxygen-containing moieties. In 2012, we discussed the outstanding physicochemical properties offered by GO and how these features can be exploited in unprecedented optical biosensing systems. [1] In fact, GO can be processed in suspension, easily complexed with biomolecules, and offers a universal highly efficient long-range photoluminescence quenching agent-among other functional properties. Furthermore, we highlighted that GO photoluminescences with energy transfer donor/acceptor molecules exposed A few years ago, crucial graphene oxide (GO) features such as the carbon/oxygen ratio, number of layers, and lateral size were scarcely investigated and, thus, their impact on the overall optical biosensing performance was almost unknown. Nowadays valuable insights about these features are well documented in the literature, whereas others remain controversial. Moreover, most of the biosensing systems based on GO were amenable to operating as colloidal suspensions. Currently, the literature reports conceptually new approaches obviating the need of GO colloidal suspensions, enabling the integration of GO onto a solid phase and leading to their application in new biosensing devices. Furthermore, most GO-based biosensing devices exploit photoluminescent signals. However, further progress is also achieved in powerful label-free optical techniques exploiting GO in biosensing, particularly using optical fibers, surface plasmon resonance, and surface enhanced Raman scattering. Herein, a critical overview on these topics is offered, highlighting the key role of the physicochemical properties of GO. New challenges and opportunities in this exciting field are also highlighted.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805043.in a planar surface. [1] However, GO properties can be tailored according to its oxidation degree, lateral size, and number of layers, which was something little explored 6 years ago, and thus their impact on the overall biosensing performance was almost unknown. In addition, most of the biosensing systems based on GO were amenable to working as colloidal suspensions. Though, recent literature reports conceptually new approaches obviating the need of colloidal suspensions, which facilitates integration of GO-based biosensors into the solid phase and allows for their applications in new devices. Furthermore, the majority of the GO-based optical biosensing techniques rely on photoluminescent signals. However, further progress has also been achieved in powerful label-free optical techniques exploiting GO in biosensing. Here, we introduce a progress report on this exciting topic, underscoring challenges and opportunities in (bio)sensing accordingly. Number of LayersGO aqueous suspensions are highly stable in the form of mono layers. However, GO multilayer films can be built via

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“…14 There are already several excellent reviews focusing on the synthesis, properties, and biosensing performance of graphene and its derivatives for biomedical applications. [15][16][17][18][19][20][21][22][23][24][25] Yet many obvious questions arise if we think of a perfect graphene-based biosensor that needs to be discussed: What makes graphene a sensitive detector for biological molecules? Does the method of production and assembly of graphene affects its biosensing performance?…”

Section: Introductionmentioning

confidence: 99%

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

2017

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Graphene has emerged as a champion material for a variety of applications cutting across multiple disciplines in science and engineering. Graphene and its derivatives have displayed huge potential as a biosensing material due to their unique physicochemical properties, good electrical conductivity, optical properties, biocompatibility, ease of functionalization, and flexibility. Their widespread use in making biosensors has opened up new possibilities for early diagnosis of life-threatening diseases and real-time health monitoring. Following an introduction and discussion on the significance of fabrication protocols and assembly, this review is intended to assess why graphene is suitable to build better biosensors, the working of existing biosensing schemes and their current status toward commercialization for wearable diagnostic and prognostic devices. We believe this review will provide a critical insight for harnessing graphene as a suitable biosensor for the clinical diagnostics, its future prospects and challenges ahead.

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Biosensors based on graphene oxide and its biomedical application

Cited by 326 publications

References 155 publications

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

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