Development of graphene oxide-wrapped gold nanorods as robust nanoplatform for ultrafast near-infrared SERS bioimaging

Qiu, Xiangdong; You, Xinru; Chen, Xing; Chen, Haolin; Dhinakar, Arvind; Liu, Songhao; Guo, Zhouyi; Wu, Jun; Liu, Zhiming

doi:10.2147/ijn.s130648

Cited by 30 publications

(8 citation statements)

References 37 publications

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“…bioimaging [32]. Qiu et al [33] developed the graphene oxide (GO)-wrapped gold nanorods (GO@GNRs) that can be used as a smart and robust nanoplatform for ultrafast NIR SERS bioimaging. Their finding demonstrated that the fabricated GO@GNRs could efficiently load various NIR probes, and the in vitro evaluation indicated that the nanoplatform could exhibit a higher NIR SERS activity in comparison with traditional gold nanostructures.…”

Section: Graphene-based Materials For Nano-bioimagingmentioning

confidence: 99%

Introductory Chapter: Nano-bioimaging—Past, Present, and Future

Ghamsari¹

2018

State of the Art in Nano-Bioimaging

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Section: Graphene-based Materials For Nano-bioimagingmentioning

confidence: 99%

Introductory Chapter: Nano-bioimaging—Past, Present, and Future

Ghamsari¹

2018

State of the Art in Nano-Bioimaging

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“…Recently, much effort of scientists has been devoted to enhancing optoelectronic response of Raman probe through fabricating organic–inorganic hybrid structures . The composites are useful not only for exploring the fundamental properties of the hybrid structure but also for creating new functional sensors with higher sensitivity.…”

Section: Introductionmentioning

confidence: 99%

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

Guo

Geng

et al. 2019

Applied Organom Chemis

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In this paper, using thiolated graphene oxide (GO‐O‐SH) as substrate, gold nanorods (AuNRs) covalently linked to the GO surface by in‐situ seed growth method were first reported. The as‐prepared composites were characterized by UV–vis spectrum, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT‐IR). Experimental results indicated that the introduction of short flexible organic chain between GO and AuNRs contributed to the homogenous synthesis of gold rods, and uniform gold nanorods with aspect ratio within 3~8 were covalently linked to the surface of GO with high stability and yield. The strategy represented an outstanding improvement in comparison to the traditional route for fabricating GO@AuNRs composites. Furthermore, based on coupling of the two nanomaterials, the composites could act as high sensitive Raman probe with limit of detection (LOD) reaching 1 × 10−12 M.

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“…[18][19][20][21] Scientists have developed various types of SERS-active nanoparticles (NPs) or chips for acquiring high-quality SERS spectra of bacteria, such as Ag NPs, 22 Ag nanowires, 23 Ag NPs@Si arrays, 24 and Au-coated magnetic NPs (MNPs), 25 because of the rapid progress of nanotechnology in recent years. Although these reported SERS substrates can amplify the Raman signal of bacteria with good specificity, the sensitivity and reliability of the SERS substrates are still easily subjected to interference in complex environments.…”

mentioning

confidence: 99%

Combined use of vancomycin-modified Ag-coated magnetic nanoparticles and secondary enhanced nanoparticles for rapid surface-enhanced Raman scattering detection of bacteria

Wang¹,

Liu³

et al. 2018

IJN

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Background Pathogenic bacteria have always been a significant threat to human health. The detection of pathogens needs to be rapid, accurate, and convenient. Methods We present a sensitive surface-enhanced Raman scattering (SERS) biosensor based on the combination of vancomycin-modified Ag-coated magnetic nanoparticles (Fe 3 O 4 @Ag-Van MNPs) and Au@Ag nanoparticles (NPs) that can effectively capture and discriminate bacterial pathogens from solution. The high-performance Fe 3 O 4 @Ag MNPs were modified with vancomycin and used as bacteria capturer for magnetic separation and enrichment. The modified MNPS were found to exhibit strong affinity with a broad range of Gram-positive and Gram-negative bacteria. After separating and rinsing bacteria, Fe 3 O 4 @Ag-Van MNPs and Au@Ag NPs were synergistically used to construct a very large number of hot spots on bacteria cells, leading to ultrasensitive SERS detection. Results The dominant merits of our dual enhanced strategy included high bacterial-capture efficiency (>65%) within a wide pH range (pH 3.0–11.0), a short assay time (<30 min), and a low detection limit (5×10 2 cells/mL). Moreover, the spiked tests show that this method is still valid in milk and blood samples. Owing to these capabilities, the combined system enabled the sensitive and specific discrimination of different pathogens in complex solution, as verified by its detection of Gram-positive bacterium Escherichia coli , Gram-positive bacterium Staphylococcus aureus , and methicillin-resistant S. aureus . Conclusion This method has great potential for field applications in food safety, environmental monitoring, and infectious disease diagnosis.

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Development of graphene oxide-wrapped gold nanorods as robust nanoplatform for ultrafast near-infrared SERS bioimaging

Cited by 30 publications

References 37 publications

Introductory Chapter: Nano-bioimaging—Past, Present, and Future

Introductory Chapter: Nano-bioimaging—Past, Present, and Future

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

Combined use of vancomycin-modified Ag-coated magnetic nanoparticles and secondary enhanced nanoparticles for rapid surface-enhanced Raman scattering detection of bacteria

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