Granulocyte macrophage colony stimulating factor (G-CSF) administration for art patients with repeated implantation failure (RIF): which route is best?

Zeyneloglu, Hulusi Bulent; Önalan, Göğşen; Durak, T.; Alyazıcı, İrem; Ünal, Ekrem

doi:10.1016/j.fertnstert.2013.07.1031

Cited by 10 publications

(10 citation statements)

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“…It seems that systemic administration is more effective and associated with a better success rate than the commonly used local intrauterine infusion (Scarpellini & Sbracia 2012, Zeyneloglu et al 2013, Barad et al 2014. In this study and the study of Scarpellini & Sbracia GCSF was administered systemically through subcutaneous injection (Scarpellini & Sbracia 2012).…”

Section: The Ideal Route and Dose Of Gcsf Administrationmentioning

confidence: 94%

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Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial

Aleyasin¹,

Abediasl²,

Nazari³

et al. 2016

Reproduction

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Recent studies have revealed key roles for granulocyte colony-stimulating factor (GCSF) in embryo implantation process and maintenance of pregnancy, and some studies showed promising results by using local intrauterine infusion of GCSF in patients undergoing in vitro fertilization (IVF). This multicenter, randomized, controlled trial included 112 infertile women with repeated IVF failure to evaluate the efficacy of systemic single-dose subcutaneous GCSF administration on IVF success in these women. In this study, the Long Protocol of ovarian stimulation was used for all participants. Sealed, numbered envelopes assigned 56 patients to receive subcutaneous 300 µg GCSF before implantation and 56 in the control group. The implantation (number of gestational sacs on the total number of transferred embryos), chemical pregnancy (positive serum β-HCG), and clinical pregnancy (gestational sac and fetal heart) rates were compared between the two groups. This trial is registered at www.irct.ir (IRCT201503119568N11). The successful implantation (18% vs 7.2%, P = 0.007), chemical pregnancy (44.6% vs 19.6%, P = 0.005), and clinical pregnancy (37.5% vs 14.3%, P = 0.005) rates were significantly higher in the intervention group than in the control group. After adjustment for participants' age, endometrial thickness, good-quality oocyte counts, number of transferred embryos, and anti-Mullerian hormone levels, GCSF treatment remained significantly associated with successful implantation (OR = 2.63, 95% CI = 1.09-6.96), having chemical pregnancy (OR= 2.74, 95% CI = 1.11-7.38) and clinical pregnancy (OR = 2.94, 95% CI = 1.23-8.33). In conclusion, administration of single-dose systemic subcutaneous GCSF before implantation significantly increases the IVF success, implantation, and pregnancy rates in infertile women with repeated IVF failure.

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Section: The Ideal Route and Dose Of Gcsf Administrationmentioning

confidence: 94%

“…In addition, most studies have infused GCSF locally into the uterine cavity. Some authors have suggested that systemic administration of GCSF might be more effective than local infusion (Barad et al 2014, Zeyneloglu et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial

Aleyasin¹,

Abediasl²,

Nazari³

et al. 2016

Reproduction

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“…Repeated implantation failure (RIF) defined as the case whereby the transferred embryos fail to implant after several In vitro fertilization (IVF) attempts which causes deep impact on the quality of life, and financial burden (1, 2). Endometrial receptivity is the limiting factor for implantation and success of IVF programs (2).…”

Section: Introductionmentioning

confidence: 99%

Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT

Arefi¹,

Fazeli

Esfahani³

et al. 2018

IJRM

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Background:Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium.Objective:The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures.Materials and Methods:This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 µg (0.5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer.Results:There was not statistically significant differences in abortion rate in G-CSF and control group (p=0.09). G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56.2% vs. 40.0%) but it was not statistically significant (p=0.09). Although live birth rate in G-CSF group was higher than control group (53.1% vs. 35.0%) but there wasn’t statistically significant difference in the overall live birth rate between the two groups (p=0.10). G-CSF group had a twin pregnancies while in control group there was no twin pregnancy.Conclusion:Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF.

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“…Previous studies had showed that G-CSF can improve recurrent pregnancy losses by increasing the infl ammation process and subsequently endometrial receptivity [8][9][10][11]. reported that the pregnancy chances and endometrial thickness was improved after G-CSF infusion [13].…”

Section: Discussionmentioning

confidence: 99%

“…Also, G-CSF transvaginal infusion successfully were utilized in women with low endometrial 3(1): 011-014. DOI: http://dx.doi.org/10.17352/jgro.000030 thickness (<7 mm) and recurrent implantation failures recently [11][12][13]. Eftekhar et al, demonstrated that intrauterine G-CSF administration increased chemical and clinical pregnancy rates in infertile women with thin endometrium in frozenthawed embryos transfer cycles but they showed in their study endometrial thickness in their patients did not improved [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on IVF Outcomes in Infertile Women

Mostafa¹,

Farid²

2017

J Gynecol Res Obstet

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Objective: The primary goal of this study was to assess the G-CSF effects on IVF outcomes in women with normal endometrial thickness. Patients and Methods:This was a randomized controlled study performed at Assisted Reproductive Techniques Center of Ain Shams University Maternity Hospital, over a 2-year period, between Jan 2014 and Jan 2016, and included 60 infertile women with normal endometrial thickness. Women were scheduled for IVF and randomized into two groups. Exclusion criteria were positive history of repeated implantation failure (RIF), endocrine disorders, severe endometriosis, congenital or acquired uterine anomaly and contraindication for G-CSF (renal disease, sickle cell disease, or malignancy). In G-CSF group (n=30), 300 μg trans-cervical intrauterine of G-CSF was administered at the oocyte retrieval day. Controls (n=30) were treated with standard protocol. Chemical, clinical and ongoing pregnancy rates, implantation rate, and miscarriage rate were compared between groups.Results: Biochemical pregnancy had occurred in 27.3% of participants in group I and 21.3% of women in group II with a signifi cant difference between the two groups. The clinical pregnancy rate was 22% and 16% in group I and II respectively with no signifi cant difference between the two groups. The acceptability of women in group I was 68%, mild discomfort occurred in 44.7%, moderate discomfort was in 28.7%, severe discomfort was in 11.3% and 15.3% of women in group I had no discomfort at all. Diffi cult fl ushing had occurred in 14.7% of women. Conclusion:It looks that the clinical pregnancy rates were signifi cantly higher by intracavitary infusion of granulocyte colony stimulating factor

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Granulocyte macrophage colony stimulating factor (G-CSF) administration for art patients with repeated implantation failure (RIF): which route is best?

Cited by 10 publications

References 0 publications

Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial

Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial

Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT

Effect of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on IVF Outcomes in Infertile Women

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