Good stress, bad stress and oxidative stress: Insights from anticipatory cortisol reactivity

Aschbacher, Kirstin; O’Donovan, Aoife; Wolkowitz, Owen M.; Dhabhar, Firdaus S.; Su, Yali; Epel, Elissa S.

doi:10.1016/j.psyneuen.2013.02.004

Cited by 367 publications

(303 citation statements)

References 53 publications

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“…Viewed in this way, exercise training still is a health‐promoting behavior, increasing the capacity to mount an enhanced, rather than diminished, inflammatory response to challenge. This position is consistent with the work of Miller and colleagues56 and, more generally, of the views of Dhabhar and colleagues54, 57, 58 and Dienstbier,59 who argued for the health benefits of significant responsiveness to challenge.…”

Section: Discussionsupporting

confidence: 85%

Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults

Sloan

Shapiro

McKinley

et al. 2018

JAHA

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BackgroundConsensus panels regularly recommend aerobic exercise for its health‐promoting properties, due in part to presumed anti‐inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti‐inflammatory effects of aerobic training elusive.Methods and ResultsWe conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)‐inducible tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), and on toll‐like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF‐α (P=0.08) and IL‐6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF‐α (51% increase, P=0.041) and IL‐6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF‐α (54% decrease, P=0.007) and IL‐6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF‐α or IL‐6.ConclusionsThe failure to support the primary hypotheses and the unexpected post hoc findings of an exercise‐training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti‐inflammatory effects.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.

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Section: Discussionsupporting

confidence: 85%

Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults

Sloan

Shapiro

McKinley

et al. 2018

JAHA

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“…SACCÀ; SHERWIN, 1979;HENNESSY et al, 1997;KOBELT et al, 2003;KUNZ-EBRECHT et al, 2003;STEPHEN;LEDGER, 2006;ACCORSI, 2008;HAVERBEKE et al, 2008;O'DONOVAN et al, 2010) and each study has analyzed a novel Cortisol salivary levels in owned dogs remained constant whereas in sheltered dogs decreased significantly over the collection period, pointing towards the capacity of dogs to adapt to stressful events, which has been described as psychobiological resilience (ASCHBACHER et al, 2013).…”

Section: Task Different Authors Consider Different Cortisol Values Amentioning

confidence: 99%

“…Common sense about cortisol elevations as negative events or preventing dogs from undergoing stress may be partially incorrect since hormonal fluctuations can make dogs feel new environmental challenges (HAVERBEKE et al, 2008;ASCHBACHER et al, 2013;GOMES DA SILVA et al, 2013). Exaggerated hormonal elevations may lead to health problems, as low immune response, psychological and neurogenic disturbances as well as physiological and behavioral alterations (DE ALMEIDA et al, 2013).…”

Section: Task Different Authors Consider Different Cortisol Values Amentioning

confidence: 99%

“…Other studies (CHRISTENSEN et al, 2007;DALLA VILLA et al, 2013) report that playing does not occur among stressed dogs, which may be the case of the owned dogs observed in the present study. We can infer that dogs in that specific shelter presented necessary levels of cortisol to develop playing as an interaction and enrichment tool leading to a healthy resilient state (ASCHBACHER et al, 2013 understand the correlation between behavior and stress in shelter and owned dogs.…”

Section: Task Different Authors Consider Different Cortisol Values Amentioning

confidence: 99%

“…For good public health practices, free-roaming population should be controlled and resettled in new homes. Unfortunately, a good number of these animals is unsociable, and ends up escaping from or not interacting Stress is conceptualized in eustress, which is the healthy stress, when hormone levels fluctuate within an acceptable organic limit for interaction with the environment, and in distress, which is the bad stress, when hormone levels exceed the organic limits, generating undesirable consequences in many organs (ACCO; PACHALY; BACILA, 1999;BEERDA et al, 1999b;DA SILVA, 1999;SCHOMMER;HELLHAMMER;PALME et al, 2005;DIESEL, 2011;ASCHBACHER et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Correlação dos parâmetros endócrinos e comportamentais em cadelas abandonadas em programa de ressocialização

Lesnau¹

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Á DEUS, que no silêncio das madrugadas, permitiu-me conhecê-Lo, entendê-Lo e me ensinou a conversar com Ele. Volto para casa com minha fé descoberta e com uma experiência íntima muito forte estabelecendo esta aliança. Graças dou! À minha mãe Otilia Wisniewski Lesnau pelas vezes em que cruzou o Brasil para socorrer minha família na minha ausência e o apoio que sempre ofereceu. A todos vocês, muito obrigado! Epígrafe "Dizem que a oportunidade é uma deusa que tem cabelo na testa, portanto você tem de apanhá-la quando ela vem de frente porque depois que ela passa, a única coisa a fazer é se lamentar". The mechanism of stress is already known and can be divided in two stages: acute stress, which releases thermogenic factors and inflammatory -mediated interleukin 6 (IL6) and chronic stress, which suppresses the inflammatory response and is mediated by the presence of cortisol. When stray dogs are housed in shelters, they undergo a period of adaptation; however, until now there is not a ressocialization program at the governmental level aiming to improve their welfare along with their new owners. The ressocialization program beginning when dogs arrive to the shelter and the correlation of dogs´ behavior with physiological and endocrine parameters related to stress have not yet been described , which raises the hypothesis that it can decrease the traumatic impact of abandonment. Twenty seven healthy bitches were divided into 3 groups: with owners, abandoned not trained and abandoned trained.The trained and abandoned dogs were later adopted. The training lasted 15 min / day for 21 days. The behavioral assessment (ethogram and ethotest) was performed every 7 days and physiological parameters assessment (heart rate, respiratory rate, blood oxygenation rate, pulse) as well as saliva collection, daily. After the adoption, the bitches were evaluated for 7 additional days. Data were analyzed by ANOVA, after testing the results for normality. The correlation between parameters was analyzed using the Pearson correlation test. Values were considered different at p < 0.05. The most surprisingly result was the maintenance of low levels of IL6 in trained dogs after neutering, whereas the other two groups showed a significant increase of IL6. The consequences of training were evident in ethograms after adoption: there was an improvement of the interaction of dogs with the new family, attitudes of playing were more numerous, and dogs showed a greater receptivity to the new owners. The tail wagging, as communication behavior, appeared much more frequently in trained dogs after adoption. Abandoned dogs after adoption manifested more idleness, discouragement and depression behaviors and reduced alertness.These results suggest that the training reassures bitches in the stressful shelter environment, improves their physiological parameters, controls fear behaviors making them more able to adapt to the new environment after adoption. There were no differences in cortisol among the groups (p > 0.05). However, IL-6 concentration was lower in ...

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Psychoneuroendocrinology of Stress

Gunnar

Doom

Esposito

2015

Handbook of Child Psychology and Developmental Science

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Developmental psychology is rapidly becoming a neuropsychobiological field concerned with understanding how the genes we are born with, the experiences we have that modify gene expression, and the physiological responses in our brains and bodies all come together to write the story of our lives. Nowhere is the importance of a multilevel, multidisciplinary, genes‐to‐society perspective more apparent than in the study of stress and its role in development. This chapter focuses on a key stress‐mediating system, the hypothalamic‐pituitary‐adrenocortical ( HPA ) axis, its development and regulatory processes, its effects on brain systems involved in emotion and cognition, and its interactions with other stress‐mediating systems. The normative development of the HPA axis is described, along with the role of temperament as a moderator of stress responding and stress effects. The majority of the chapter summarizes evidence that the HPA axis plays a role in the biological embedding of experience during development, including questions about developmental plasticity and developmental programming in relation to poverty, prenatal stress, parental loss, risky family environments, and maltreatment. The role of the HPA axis in developmental psychopathology is also discussed. Future directions and fruitful areas of research are considered with each topic.

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Good stress, bad stress and oxidative stress: Insights from anticipatory cortisol reactivity

Cited by 367 publications

References 53 publications

Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults

Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults

Correlação dos parâmetros endócrinos e comportamentais em cadelas abandonadas em programa de ressocialização

Psychoneuroendocrinology of Stress

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