Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

Abstract

Glyphosate, the active ingredient in Roundup ®

Death as a Drug Side Effect in FAERS: Is Glyphosate Contamination a Factor?

“…For instance, in [41], it was proposed that glyphosate could be causal in Parkinson's disease through manganese toxicity in the brain stem, consequential to manganese accumulation in the liver through disrupted bile flow. Manganese then traverses the vagus nerve to accumulate in the brain stem.…”

Glyphosate, pathways to modern diseases IV: cancer and related pathologies

“…Glyphosate is toxic to many microbes as well as to most plants, and one likely effect of chronic low-dose oral exposure to glyphosate is a disruption of the balance among gut microbes towards an over-representation of pathogens [11]. This leads to a chronic inflammatory state in the gut, as well as an impaired gut barrier and many other sequelae.…”

“…Glyphosate likely contributes to the destruction of CYP enzymes both through H 2 O 2 attack at their haem centre as well as through direct interference via nitrosylation at the active site by glyphosate [11]. CYP-mediated drug metabolism is impaired in patients with liver disease, particularly CYP1A, CYP2C19, and CYP3A [135], and this makes these individuals even more susceptible to liver damage.…”

Protection against Gluten-mediated Tight Junction Injury with a Novel Lignite Extract Supplement

“…These tight junctions function as selective gatekeepers that regulate the absorption of macronutrients, and compose a frontline of defense. The increased gut permeability that results from tight junction dysfunction is increasingly recognized as an early step in the pathogenesis of many acute and chronic inflammatory diseases, including celiac disease and inflammatory bowel disease (Crohn's Disease and ulcerative colitis) [1][2][3][4][5][6]. The chronic inflammatory underpinnings of these conditions point to the chronic immune system activation of the gastrointestinal-associated lymphoid tissue that becomes exposed with tight junction dysfunction.…”