Glycosides, Synthesis and Characterization

Brito-Arias, Marco

doi:10.1007/978-3-030-97854-9_1

Cited by 3 publications

(3 citation statements)

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“…Inactive glycosides are the primary type of chemical storage in many plants. These can be made active by enzyme hydrolysis, which separates the aglycone part from the sugar component and makes it therapeutically active 118 . The crucial molecular targets of glycosides are sterol regulatory element-binding protein 1 (SREBP-1), ACC, FAS, NF- κ B, PI3K-AKT pathway, PPAR- α , and several other pathways.…”

Section: Glycosidesmentioning

confidence: 99%

Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms

Banerjee,

Sarkar,

Ali

et al. 2024

Planta Med

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Non-alcoholic fatty liver disease (NAFLD), with a global prevalence of 25%, continues to escalate, creating noteworthy concerns towards the global health burden. NAFLD causes triglycerides and free fatty acids to build-up in the liver. The excessive fat build-up causes inflammation and damages the healthy hepatocytes leading to non-alcoholic steatohepatitis (NASH). Dietary habits, obesity, insulin resistance, type 2 diabetes, and dyslipidemia influence NAFLD progression. The disease burden is complicated due to the paucity of therapeutic interventions. Obeticholic acid is the only approved therapeutic agent for NAFLD. With more scientific enterprise being directed towards understanding of underlying mechanisms of NAFLD, novel targets like lipid synthase, farnesoid X receptor signalling, peroxisome proliferator-activated receptors associated with inflammatory signalling and hepatocellular injury have played a crucial role in progression of NAFLD to NASH. Phytocompounds have shown promising results in modulating hepatic lipid metabolism and de novo lipogenesis suggesting their possible role in managing NAFLD. This review discusses the ameliorative role of different classes of phytochemicals with molecular mechanisms in different cell lines and established animal models. These compounds may lead to the development of novel therapeutic strategies for NAFLD progression to NASH. This review also deliberates on phytomolecules undergoing clinical trials for effective management of NAFLD.

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Section: Glycosidesmentioning

confidence: 99%

Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms

Banerjee,

Sarkar,

Ali

et al. 2024

Planta Med

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“…Tannins are actively used in the preparation of herbal-based medicines. According to studies, herbal tannins are used as astringents (stopping bleeding, constricting vessels) against diarrhea and as an auretic and antiinflammatory against stomach and duodenal tumors (Brito-Arias, 2007;Fujiki et al, 2012). In addition, anti-tumor, cardioprotective, anti-inflammatory, and antimicrobial activities are defined for tannins (Hossain et al, 2021;Jing et al, 2022;Maugeri et al, 2022).…”

Section: Secondary Metabolites 21 Phenolic Compoundsmentioning

confidence: 99%

Production of secondary metabolites using tissue culture-based biotechnological applications

et al. 2023

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Plants are the sources of many bioactive secondary metabolites which are present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to the plants in many cases, they are not necessary for metabolisms related to growth, development, and reproduction. They are specific to plant species and are precursor substances, which can be modified for generations of various compounds in different plant species. Secondary metabolites are used in many industries, including dye, food processing and cosmetic industries, and in agricultural control as well as being used as pharmaceutical raw materials by humans. For this reason, the demand is high; therefore, they are needed to be obtained in large volumes and the large productions can be achieved using biotechnological methods in addition to production, being done with classical methods. For this, plant biotechnology can be put in action through using different methods. The most important of these methods include tissue culture and gene transfer. The genetically modified plants are agriculturally more productive and are commercially more effective and are valuable tools for industrial and medical purposes as well as being the sources of many secondary metabolites of therapeutic importance. With plant tissue culture applications, which are also the first step in obtaining transgenic plants with having desirable characteristics, it is possible to produce specific secondary metabolites in large-scale through using whole plants or using specific tissues of these plants in laboratory conditions. Currently, many studies are going on this subject, and some of them receiving attention are found to be taken place in plant biotechnology and having promising applications. In this work, particularly benefits of secondary metabolites, and their productions through tissue culture-based biotechnological applications are discussed using literature with presence of current studies.

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“…The structural alteration resulting from the transformation of the anomeric centre from C–O acetal to a strong C–C bond in C -glycosides stimulates the resistance towards chemical/enzymatic hydrolysis and metabolic processes. 2 As a consequence, the dominance of C -glycosides to personate native O -glycosides as potential therapeutic candidates has become undoubtedly apparent. Moreover, the occurrence of C -glycosidic linkage is common in natural products obtained from plants and microorganisms, such as saptomycin B, 3 mangiferin, 4 aspalathin, 5 tunicamycin V, 6 and aureonuclemycin, 7 which have shown significant biological activities 8 (Fig.…”

Section: Introductionmentioning

confidence: 99%